NPBWR1 (neuropeptides B and W receptor 1)

Gene

• Entrez ID: 2831
• Gene name: Neuropeptides B and W receptor 1
• Gene symbol: NPBWR1
• Synonyms (NCBI Gene): GPR7
• Chromosome: 8
• Chromosome location: 8q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT718355	hsa-miR-6805-5p	HITS-CLIP	19536157
MIRT718354	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT718353	hsa-miR-1292-3p	HITS-CLIP	19536157
MIRT718352	hsa-miR-3195	HITS-CLIP	19536157
MIRT718351	hsa-miR-4783-5p	HITS-CLIP	19536157
MIRT718350	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT718349	hsa-miR-4488	HITS-CLIP	19536157
MIRT718348	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT619951	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT619950	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT619949	hsa-miR-603	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619948	hsa-miR-3941	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT718355	hsa-miR-6805-5p	HITS-CLIP	19536157
MIRT718354	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT718353	hsa-miR-1292-3p	HITS-CLIP	19536157
MIRT718352	hsa-miR-3195	HITS-CLIP	19536157
MIRT718351	hsa-miR-4783-5p	HITS-CLIP	19536157
MIRT718350	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT718349	hsa-miR-4488	HITS-CLIP	19536157
MIRT718348	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT619951	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT619950	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT619949	hsa-miR-603	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619948	hsa-miR-3941	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004985	Function	Opioid receptor activity	TAS	7590751
GO:0005515	Function	Protein binding	IPI	12401809, 32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12401809
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS	7590751
GO:0008188	Function	Neuropeptide receptor activity	IEA
GO:0016021	Component	Integral component of membrane	IC	12401809
GO:0019222	Process	Regulation of metabolic process	IEA
GO:0038003	Process	Opioid receptor signaling pathway	IEA
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045202	Component	Synapse	IEA

Other IDs

• MIM: 600730
• HGNC: 4522
• e!Ensembl: ENSG00000288611

Protein

• UniProt ID: P48145
• Protein name: Neuropeptides B/W receptor type 1 (G-protein coupled receptor 7)
• Protein function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	54 → 307	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high le
• Sequence:

  MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY
  VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT
  FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD
  DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK
  ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
  CLNPFLYAFLDASFRRNLRQLITCRAAA

• Sequence length: 328

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Peptide ligand-binding receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Non Small Cell Lung	Associate	24081945
Cerebral Palsy	Stimulate	35705018
Prodromal Symptoms	Associate	24081945