ANG (angiogenin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
283
Gene name Gene Name - the full gene name approved by the HGNC.
Angiogenin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANG
Synonyms (NCBI Gene) Gene synonyms aliases
ALS9, HEL168, RAA1, RNASE4, RNASE5
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called an
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(86)
miRTarBase ID miRNA Experiments Reference
MIRT006649 hsa-miR-409-3p Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 22531314
MIRT018344 hsa-miR-335-5p Microarray 18185580
MIRT024617 hsa-miR-215-5p Microarray 19074876
MIRT026610 hsa-miR-192-5p Microarray 19074876
MIRT517273 hsa-miR-5580-3p HITS-CLIP 21572407
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
CTCF Unknown 24659782
PPARD Repression 17511960
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(91)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IBA
GO:0001525 Process Angiogenesis IDA 8448182
GO:0001525 Process Angiogenesis IDA 3470787, 4074709
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IMP 2479414, 17125737
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
105850 483 ENSG00000214274
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P03950
Protein name Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5)
Protein function Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed:12051708, PubMed:1400510, PubMed:19332886, PubMed:20129916, PubMed:21855800, PubMed:23047679, PubMed:23843625, PubMed:
PDB 1A4Y , 1ANG , 1AWZ , 1B1E , 1B1I , 1B1J , 1GV7 , 1H0D , 1H52 , 1H53 , 1HBY , 1K58 , 1K59 , 1K5A , 1K5B , 1UN3 , 1UN4 , 1UN5 , 2ANG , 4AHD , 4AHE , 4AHF , 4AHG , 4AHH , 4AHI , 4AHJ , 4AHK , 4AHL , 4AHM , 4AHN , 4AOH , 4B36 , 5EOP , 5EPZ , 5EQO , 5M9A , 5M9C , 5M9G , 5M9J , 5M9M , 5M9P , 5M9Q , 5M9R , 5M9S , 5M9T , 5M9V , 7NPM , 7PNJ , 7PNP , 7PNR , 8AF0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00074 RnaseA 28 → 140 Pancreatic ribonuclease Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in the liver (PubMed:2440105). Also detected in endothelial cells and spinal cord neurons (PubMed:17886298, PubMed:2440105). {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.
Sequence
Sequence length 147
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Amyotrophic lateral sclerosis   Adherens junctions interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis type 9 rs121909540, rs121909542, rs121909544, rs121909535, rs121909537, rs121909538, rs121909539 N/A
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Schizophrenia Schizophrenia N/A N/A GWAS
Show/Hide Text Mining Associations (69)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Stimulate 33337366
Amyopathic dermatomyositis Associate 23229115
Amyotrophic Lateral Sclerosis Associate 17886298, 19363631, 19449021, 20577002, 21085671, 22384259, 22752089, 23100398, 23228179, 23393617, 23665167, 23755159, 23881933, 25372031, 25386690
View all (8 more)
Amyotrophic lateral sclerosis 1 Associate 20577002, 23228179, 25386690
Astrocytoma Associate 25659096
Autoimmune Diseases Associate 24860242
Breast Neoplasms Associate 23977052, 24457100
Carcinogenesis Associate 11579593, 27317771
Carcinoma Hepatocellular Associate 14600132, 29614505, 33228611
Carcinoma Non Small Cell Lung Associate 40007122