IFNL3 (interferon lambda 3)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 282617
Gene name Interferon lambda 3
Gene symbol IFNL3
Synonyms (NCBI Gene)
IFN-lambda-3IFN-lambda-4IL-28BIL-28CIL28BIL28C
Chromosome 19
Chromosome location 19q13.2
Summary This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region map
SNPs SNP information provided by dbSNP.
1
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
SNP ID Visualize variation Clinical significance Consequence
rs11881222 A>G Drug-response Intron variant
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
IRF7 Unknown 17785777
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IBA
GO:0005125 Function Cytokine activity IEA
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607402 18365 ENSG00000197110
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IZI9
Protein name Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)
Protein function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10
PDB 3HHC , 5T5W , 9BPV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15177 IL28A 34 → 192 Interleukin-28A Domain
Sequence
Sequence length 196
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway 		  Interleukin-20 family signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Gene SNPs Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
interferons, peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy drug response rs8099917 RCV000211192
peginterferon alfa-2a response - Efficacy drug response rs11881222 RCV000417187
peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy drug response rs8099917 RCV000211316
peginterferon alfa-2b response - Efficacy drug response rs11881222 RCV000417140
Show/Hide Text Mining Associations (92)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 25259701, 30234607
Alzheimer Disease Stimulate 32046242
Anemia Associate 23133602, 26110293, 26670100, 26933517, 29851985
Asthma Associate 24475887
Autoimmune Diseases Associate 27613139
beta Thalassemia Associate 22180419, 25864220, 31269695
Bronchiolitis Associate 24389019, 31645053
Carcinoma Hepatocellular Associate 22310928, 23008132, 23227209, 23712427, 24516704, 25227816, 25332265, 25504078, 26602024, 26757951, 26854475, 27035616, 27183918, 29095252, 29254684
View all (6 more)
Carcinoma Hepatocellular Stimulate 25811035
Carcinoma Hepatocellular Inhibit 25837166