Gene Gene information from NCBI Gene database.
Entrez ID 28232
Gene name Solute carrier organic anion transporter family member 3A1
Gene symbol SLCO3A1
Synonyms (NCBI Gene)
OATP-DOATP-RP3OATP3A1OATPDOATPRP3SLC21A11
Chromosome 15
Chromosome location 15q26.1
miRNA miRNA information provided by mirtarbase database.
309
miRTarBase ID miRNA Experiments Reference
MIRT024914 hsa-miR-215-5p Microarray 19074876
MIRT026667 hsa-miR-192-5p Microarray 19074876
MIRT051495 hsa-let-7e-5p CLASH 23622248
MIRT038665 hsa-miR-218-1-3p CLASH 23622248
MIRT699236 hsa-miR-6758-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IDA 21278488
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0006811 Process Monoatomic ion transport IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612435 10952 ENSG00000176463
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UIG8
Protein name Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion tr
Protein function Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycoch
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03137 OATP 41 622 Organic Anion Transporter Polypeptide (OATP) family Family
PF07648 Kazal_2 472 513 Kazal-type serine protease inhibitor domain Domain
Tissue specificity TISSUE SPECIFICITY: Generally the expression of isoform 1 is higher than that of isoform 2. {ECO:0000269|PubMed:16971491}.; TISSUE SPECIFICITY: [Isoform 1]: Expressed in placental trophoblasts (PubMed:10873595, PubMed:12409283). Expressed in pancreas, kid
Sequence
Sequence length 710
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Transport of organic anions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER'S DISEASE NEUROPATHOLOGIC CHANGE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CANDIDEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
3C syndrome Stimulate 21383546
★☆☆☆☆
Found in Text Mining only
Antisocial Personality Disorder Associate 37756443
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 21383546
★☆☆☆☆
Found in Text Mining only
Cholestasis Stimulate 34971708
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Associate 21383546
★☆☆☆☆
Found in Text Mining only
Corneal Perforation Associate 24945726
★☆☆☆☆
Found in Text Mining only
Crohn Disease Associate 24945726
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 24945726, 40076698
★☆☆☆☆
Found in Text Mining only
Intestinal Perforation Associate 24945726
★☆☆☆☆
Found in Text Mining only
Intrahepatic Cholestasis of Pregnancy Associate 34638773
★☆☆☆☆
Found in Text Mining only