Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2820
Gene name Gene Name - the full gene name approved by the HGNC.
Glycerol-3-phosphate dehydrogenase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPD2
Synonyms (NCBI Gene) Gene synonyms aliases
GDH2, GPDM, mGDH, mGPDH
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q24.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosp
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121918407 T>A,C Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005147 hsa-miR-30a-5p pSILAC 18668040
MIRT001364 hsa-miR-1-3p pSILAC 18668040
MIRT017991 hsa-miR-335-5p Microarray 18185580
MIRT001364 hsa-miR-1-3p Proteomics 18668040
MIRT001364 hsa-miR-1-3p Proteomics;Microarray 18668037
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004368 Function Glycerol-3-phosphate dehydrogenase (quinone) activity TAS
GO:0005509 Function Calcium ion binding IEA
GO:0005739 Component Mitochondrion IBA 21873635
GO:0005739 Component Mitochondrion IDA
GO:0005743 Component Mitochondrial inner membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138430 4456 ENSG00000115159
Protein
UniProt ID P43304
Protein name Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD)
Protein function Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01266 DAO 71 441 FAD dependent oxidoreductase Domain
PF16901 DAO_C 462 588 C-terminal domain of alpha-glycerophosphate oxidase Family
Sequence
Sequence length 727
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerophospholipid metabolism   Synthesis of PA
Triglyceride catabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
16123366
Myopia Myopia rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805
View all (6 more)
27182965
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease term Disease name Evidence References Source
Diabetes Mellitus diabetes mellitus, noninsulin-dependent GenCC
Lung adenocarcinoma Lung adenocarcinoma Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors GWAS, CBGDA
Motion Sickness Motion Sickness GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 39509399
Developmental Disabilities Associate 31893020
Esophageal Squamous Cell Carcinoma Associate 31815134
Neoplasms Associate 36592694, 39509399
Neuroblastoma Associate 36592694
Prostatic Neoplasms Associate 32717855