Gene Gene information from NCBI Gene database.
Entrez ID 2786
Gene name G protein subunit gamma 4
Gene symbol GNG4
Synonyms (NCBI Gene)
HG3C
Chromosome 1
Chromosome location 1q42.3
miRNA miRNA information provided by mirtarbase database.
379
miRTarBase ID miRNA Experiments Reference
MIRT690557 hsa-miR-4695-5p HITS-CLIP 23313552
MIRT690556 hsa-miR-1910-3p HITS-CLIP 23313552
MIRT690555 hsa-miR-6511a-5p HITS-CLIP 23313552
MIRT690554 hsa-miR-4257 HITS-CLIP 23313552
MIRT690553 hsa-miR-4459 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23021213, 32296183
GO:0005834 Component Heterotrimeric G-protein complex IBA
GO:0005834 Component Heterotrimeric G-protein complex IEA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 7665596
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604388 4407 ENSG00000168243
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50150
Protein name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00631 G-gamma 9 75 GGL domain Domain
Tissue specificity TISSUE SPECIFICITY: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.
Sequence
Sequence length 75
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ras signaling pathway
Chemokine signaling pathway
Hormone signaling
PI3K-Akt signaling pathway
Apelin signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Relaxin signaling pathway
Morphine addiction
Alcoholism
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
  Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BENIGN CHONDROGENIC NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BONE BENIGN NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BONE NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSORIATIC ARTHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 34269159
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Stimulate 34951127
★☆☆☆☆
Found in Text Mining only
Asthma Associate 34456632
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 33499882
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 33505535
★☆☆☆☆
Found in Text Mining only
Cognition Disorders Associate 29338302, 37139702
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Associate 37448185
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 30016783, 34275892, 34473751, 37448185
★☆☆☆☆
Found in Text Mining only
Hypoxia Brain Stimulate 34951127
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Associate 35184748
★☆☆☆☆
Found in Text Mining only