Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2781
Gene name Gene Name - the full gene name approved by the HGNC.	G protein subunit alpha z
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GNAZ
Synonyms (NCBI Gene) Gene synonyms aliases	HG1H, gz-alpha
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.22-q11.23
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlea

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miRTarBase ID	miRNA	Experiments	Reference
MIRT046159	hsa-miR-30b-5p	CLASH	23622248
MIRT641644	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT641643	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT641641	hsa-miR-4469	HITS-CLIP	23824327
MIRT641642	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT641640	hsa-miR-7152-3p	HITS-CLIP	23824327
MIRT641639	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT641638	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT641637	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT641636	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT641644	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT641643	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT641641	hsa-miR-4469	HITS-CLIP	23824327
MIRT641642	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT641640	hsa-miR-7152-3p	HITS-CLIP	23824327
MIRT641639	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT641638	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT641637	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT641636	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT1023753	hsa-miR-1290	CLIP-seq
MIRT1023754	hsa-miR-1303	CLIP-seq
MIRT1023755	hsa-miR-205	CLIP-seq
MIRT1023756	hsa-miR-217	CLIP-seq
MIRT1023757	hsa-miR-3125	CLIP-seq
MIRT1023758	hsa-miR-3127-3p	CLIP-seq
MIRT1023759	hsa-miR-3177-3p	CLIP-seq
MIRT1023760	hsa-miR-3667-3p	CLIP-seq
MIRT1023761	hsa-miR-3916	CLIP-seq
MIRT1023762	hsa-miR-3917	CLIP-seq
MIRT1023763	hsa-miR-4418	CLIP-seq
MIRT1023764	hsa-miR-4659a-5p	CLIP-seq
MIRT1023765	hsa-miR-4659b-5p	CLIP-seq
MIRT1023766	hsa-miR-4776-3p	CLIP-seq
MIRT1023767	hsa-miR-509-3-5p	CLIP-seq
MIRT1023768	hsa-miR-509-5p	CLIP-seq
MIRT1023769	hsa-miR-512-5p	CLIP-seq
MIRT1023770	hsa-miR-545	CLIP-seq
MIRT1023771	hsa-miR-877	CLIP-seq
MIRT2003556	hsa-miR-3937	CLIP-seq
MIRT2236387	hsa-miR-197	CLIP-seq
MIRT2236388	hsa-miR-2682	CLIP-seq
MIRT2003556	hsa-miR-3937	CLIP-seq
MIRT2236389	hsa-miR-449c	CLIP-seq
MIRT2236390	hsa-miR-5096	CLIP-seq
MIRT2236391	hsa-miR-629	CLIP-seq
MIRT2236392	hsa-miR-940	CLIP-seq
MIRT2540091	hsa-miR-4282	CLIP-seq
MIRT2540092	hsa-miR-4468	CLIP-seq
MIRT2540093	hsa-miR-513a-3p	CLIP-seq
MIRT2540094	hsa-miR-9	CLIP-seq
MIRT2681707	hsa-miR-136	CLIP-seq
MIRT2681708	hsa-miR-3183	CLIP-seq
MIRT2681709	hsa-miR-4279	CLIP-seq
MIRT2681710	hsa-miR-4723-3p	CLIP-seq
MIRT2681711	hsa-miR-652	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	2117645
GO:0005515	Function	Protein binding	IPI	28891236
GO:0005525	Function	GTP binding	IEA
GO:0005635	Component	Nuclear envelope	TAS	2117645
GO:0005737	Component	Cytoplasm	IBA
GO:0005783	Component	Endoplasmic reticulum	TAS	2117645
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	3129724
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	3129724
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0010855	Function	Adenylate cyclase inhibitor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0019001	Function	Guanyl nucleotide binding	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IBA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IEA
GO:0031821	Function	G protein-coupled serotonin receptor binding	IEA
GO:0044297	Component	Cell body	IEA
GO:0045202	Component	Synapse	IEA
GO:0046676	Process	Negative regulation of insulin secretion	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA

MIM	HGNC	e!Ensembl
139160	4395	ENSG00000128266

Protein

UniProt ID

P19086

Protein name

Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)

Protein function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

PDB

8DZS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00503	G-alpha	13 → 344	G-protein alpha subunit	Domain

Sequence

MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGG
FNLEACKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPDRAYDAVQLFALTGPAESKGEI
TPELLGVMRRLWADPGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRD
MTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQ
TSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLAEKIRRIPLTICFPEYKGQNTYEEA
AVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGLC

Sequence length

355

Interactions

View interactions

	KEGG		Reactome
	Long-term depression		PLC beta mediated events G-protein activation G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

GNAZ (G protein subunit alpha z)