Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2770
Gene name Gene Name - the full gene name approved by the HGNC.
G protein subunit alpha i1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GNAI1
Synonyms (NCBI Gene) Gene synonyms aliases
Gi, HG1B, NEDHISB
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDHISB
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.11
Summary Summary of gene provided in NCBI Entrez Gene.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021108 hsa-miR-186-5p Sequencing 20371350
MIRT023552 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT054488 hsa-miR-320a Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining 23691483
MIRT054489 hsa-miR-320c Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining 23691483
MIRT054490 hsa-miR-320d Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining 23691483
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding ISS
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0001664 Function G protein-coupled receptor binding ISS
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
139310 4384 ENSG00000127955
Protein
UniProt ID P63096
Protein name Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Protein function Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMe
PDB 1KJY , 1Y3A , 2G83 , 2GTP , 2IK8 , 2OM2 , 2XNS , 3ONW , 3QE0 , 3QI2 , 3UMR , 3UMS , 4G5Q , 5JS7 , 5JS8 , 5TDH , 6CMO , 6CRK , 6DDE , 6DDF , 6KPF , 6KPG , 6LFM , 6LFO , 6LML , 6N4B , 6OMM , 6OS9 , 6OSA , 6OT0 , 6PB0 , 6PB1 , 6PT0 , 6QNO , 6VU8 , 6XBJ , 6XBK , 6XBL , 6XBM , 7CMU , 7CMV , 7DB6 , 7DW9 , 7E2X , 7E2Y , 7E2Z , 7E32 , 7E33 , 7E9G , 7EB2 , 7EJX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha 13 343 G-protein alpha subunit Domain
Sequence
Sequence length 354
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Hormone signaling
Adrenergic signaling in cardiomyocytes
Axon guidance
Apelin signaling pathway
Gap junction
Platelet activation
Leukocyte transendothelial migration
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Growth hormone synthesis, secretion and action
Gastric acid secretion
Parkinson disease
Cocaine addiction
Morphine addiction
Alcoholism
Pertussis
Chagas disease
Toxoplasmosis
Human cytomegalovirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
  PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Extra-nuclear estrogen signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 25918132 ClinVar
Neurodevelopmental Disorders complex neurodevelopmental disorder GenCC
Schizophrenia Schizophrenia GWAS
Tremor Tremor GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alcoholism Associate 35164291
Alzheimer Disease Associate 22982105
Anxiety Associate 28969474
Aortic Dissection Associate 36959563
Blood Platelet Disorders Associate 35296084
Brain Diseases Associate 34685729
Breast Neoplasms Associate 23591873
Carcinogenesis Associate 29307797, 29693178
Carcinoma Hepatocellular Associate 9362361
Carcinoma Renal Cell Associate 26043775