Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2768
Gene name Gene Name - the full gene name approved by the HGNC.
G protein subunit alpha 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GNA12
Synonyms (NCBI Gene) Gene synonyms aliases
HG1M1, NNX3, RMP, gep
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p22.3-p22.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023075 hsa-miR-124-3p Microarray 18668037
MIRT027790 hsa-miR-98-5p Microarray 19088304
MIRT028098 hsa-miR-93-5p Sequencing 20371350
MIRT046311 hsa-miR-23b-3p CLASH 23622248
MIRT045616 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001664 Function G protein-coupled receptor binding IEA
GO:0001701 Process In utero embryonic development IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604394 4380 ENSG00000146535
Protein
UniProt ID Q03113
Protein name Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:2
PDB 7YDJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha 37 370 G-protein alpha subunit Domain
Sequence
Sequence length 381
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Hormone signaling
Vascular smooth muscle contraction
Long-term depression
Regulation of actin cytoskeleton
Parathyroid hormone synthesis, secretion and action
Pathogenic Escherichia coli infection
Human cytomegalovirus infection
Pathways in cancer
  G alpha (12/13) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Hypertension Hypertension (confirmatory factor analysis Factor 12) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 38250763
Alzheimer Disease Associate 38353984
Brain Diseases Associate 38353984
Breast Neoplasms Stimulate 28394299
Carcinogenesis Associate 11136230, 16787920
Colorectal Neoplasms Associate 19098285
Depressive Disorder Associate 22348086
Diabetes Mellitus Type 2 Associate 22348086
Genetic Diseases Inborn Associate 22348086
Glioblastoma Associate 39849652