Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2762
Gene name	GDP-mannose 4,6-dehydratase
Gene symbol	GMDS
Synonyms (NCBI Gene)	GMDSDR3E1
Chromosome	6
Chromosome location	6p25.3
Summary	GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are c

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miRTarBase ID	miRNA	Experiments	Reference
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT526051	hsa-miR-4803	PAR-CLIP	22012620
MIRT526050	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT526049	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT526048	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT526047	hsa-miR-3128	PAR-CLIP	22012620
MIRT526046	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT526045	hsa-miR-4720-5p	PAR-CLIP	22012620
MIRT526044	hsa-miR-4799-3p	PAR-CLIP	22012620
MIRT526043	hsa-miR-5588-5p	PAR-CLIP	22012620
MIRT526042	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT526041	hsa-miR-496	PAR-CLIP	22012620
MIRT526040	hsa-miR-3143	PAR-CLIP	22012620
MIRT526039	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT526038	hsa-miR-1231	PAR-CLIP	22012620
MIRT526037	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT440560	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440560	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT526051	hsa-miR-4803	PAR-CLIP	22012620
MIRT526050	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT526049	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT526048	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT526047	hsa-miR-3128	PAR-CLIP	22012620
MIRT526046	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT526045	hsa-miR-4720-5p	PAR-CLIP	22012620
MIRT526044	hsa-miR-4799-3p	PAR-CLIP	22012620
MIRT526043	hsa-miR-5588-5p	PAR-CLIP	22012620
MIRT526042	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT526041	hsa-miR-496	PAR-CLIP	22012620
MIRT526040	hsa-miR-3143	PAR-CLIP	22012620
MIRT526039	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT526038	hsa-miR-1231	PAR-CLIP	22012620
MIRT526037	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT1022450	hsa-miR-1909	CLIP-seq
MIRT1022451	hsa-miR-214	CLIP-seq
MIRT1022452	hsa-miR-3197	CLIP-seq
MIRT1022453	hsa-miR-3619-5p	CLIP-seq
MIRT1022454	hsa-miR-761	CLIP-seq
MIRT1022450	hsa-miR-1909	CLIP-seq
MIRT1022452	hsa-miR-3197	CLIP-seq
MIRT2236037	hsa-miR-4493	CLIP-seq
MIRT2236038	hsa-miR-4719	CLIP-seq
MIRT2236039	hsa-miR-4758-3p	CLIP-seq
MIRT2236040	hsa-miR-513b	CLIP-seq
MIRT2236041	hsa-miR-744	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IC	9525924
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007219	Process	Notch signaling pathway	ISS
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IBA
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IDA	9525924
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IEA
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IGI	9603974
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	TAS
GO:0016829	Function	Lyase activity	IEA
GO:0019673	Process	GDP-mannose metabolic process	IDA	9525924
GO:0019673	Process	GDP-mannose metabolic process	IEA
GO:0019673	Process	GDP-mannose metabolic process	IGI	9603974
GO:0042350	Process	GDP-L-fucose biosynthetic process	TAS
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IBA
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IDA	9525924
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 31515488, 32296183
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070401	Function	NADP+ binding	IDA	9525924

MIM	HGNC	e!Ensembl
602884	4369	ENSG00000112699

O60547

Protein name

GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)

Protein function

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

PDB

1T2A , 5IN4 , 5IN5 , 6GPJ , 6GPK , 6GPL , 6Q94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16363	GDP_Man_Dehyd	27 → 358	GDP-mannose 4,6 dehydratase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in pancreas and small intestine. Expressed in thymus, protstate, colon, heart, placenta, liver and kidney. Expressed at low levels in spleen, testis, brain and lung. {ECO:0000269|PubMed:9525924}.

Sequence

MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA

Sequence length

372

Interactions

View interactions

	KEGG		Reactome
	Fructose and mannose metabolism Biosynthesis of various nucleotide sugars Metabolic pathways Biosynthesis of nucleotide sugars		GDP-fucose biosynthesis

GMDS (GDP-mannose 4,6-dehydratase)