Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2740
Gene name Gene Name - the full gene name approved by the HGNC.
Glucagon like peptide 1 receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GLP1R
Synonyms (NCBI Gene) Gene synonyms aliases
GLP-1, GLP-1-R, GLP-1R
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT640779 hsa-miR-4308 HITS-CLIP 23824327
MIRT640778 hsa-miR-4292 HITS-CLIP 23824327
MIRT640777 hsa-miR-6791-5p HITS-CLIP 23824327
MIRT628189 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT640776 hsa-miR-4780 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004888 Function Transmembrane signaling receptor activity TAS 8405712
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004967 Function Glucagon receptor activity IBA
GO:0004967 Function Glucagon receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138032 4324 ENSG00000112164
Protein
UniProt ID P43220
Protein name Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)
Protein function G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that l
PDB 3C59 , 3C5T , 3IOL , 4ZGM , 5E94 , 5NX2 , 5OTT , 5OTU , 5OTV , 5OTW , 5OTX , 5VEW , 5VEX , 6B3J , 6GB1 , 6ORV , 6VCB , 6X18 , 6X19 , 6X1A , 6XOX , 7C2E , 7DUQ , 7DUR , 7E14 , 7EVM , 7FIM , 7KI0 , 7KI1 , 7LCI , 7LCJ , 7LCK , 7LLL , 7LLY , 7RG9 , 7RGP , 7RTB , 7S15 , 7S1M , 7S3I , 7VBH , 7VBI , 7X8R , 7X8S , 8JIP , 8JIR , 8JIS , 8WG7 , 8YW3 , 9IVG , 9IVM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 59 129 Hormone receptor domain Family
PF00002 7tm_2 141 398 7 transmembrane receptor (Secretin family) Family
Sequence
Sequence length 463
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Insulin secretion
  Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes, Glycaemic response to GLP-1 agonist treatment in type 2 diabetes (HbA1c reduction), Type 2 diabetes (PheCode 250.2) N/A N/A GWAS
Heart Failure Heart failure N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 39777709
Adenocarcinoma of Lung Associate 39777709
Adenoma Associate 21636702
Alzheimer Disease Inhibit 23020846
Alzheimer Disease Associate 29235507
Angina Stable Associate 25848859
Anhedonia Associate 32213216
Arthritis Rheumatoid Associate 30897288
Arthritis Rheumatoid Stimulate 34502360
Atherosclerosis Associate 20495843, 33854404