Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2740
Gene name	Glucagon like peptide 1 receptor
Gene symbol	GLP1R
Synonyms (NCBI Gene)	GLP-1GLP-1-RGLP-1R
Chromosome	6
Chromosome location	6p21.2
Summary	This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response

184

Show/Hide all (184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT640774	hsa-miR-623	HITS-CLIP	23824327
MIRT640773	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT640772	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640770	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT640769	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	27418678
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT640774	hsa-miR-623	HITS-CLIP	23824327
MIRT640773	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT640772	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640770	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT640769	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1021366	hsa-miR-122	CLIP-seq
MIRT1021367	hsa-miR-150	CLIP-seq
MIRT1021368	hsa-miR-2110	CLIP-seq
MIRT1021369	hsa-miR-3150a-3p	CLIP-seq
MIRT1021370	hsa-miR-3153	CLIP-seq
MIRT1021371	hsa-miR-3175	CLIP-seq
MIRT1021372	hsa-miR-3192	CLIP-seq
MIRT1021373	hsa-miR-4260	CLIP-seq
MIRT1021374	hsa-miR-4271	CLIP-seq
MIRT1021375	hsa-miR-4428	CLIP-seq
MIRT1021376	hsa-miR-4667-5p	CLIP-seq
MIRT1021377	hsa-miR-4700-5p	CLIP-seq
MIRT1021378	hsa-miR-4713-5p	CLIP-seq
MIRT1021379	hsa-miR-4725-3p	CLIP-seq
MIRT1021380	hsa-miR-4728-5p	CLIP-seq
MIRT1021381	hsa-miR-532-3p	CLIP-seq
MIRT1021382	hsa-miR-548a-5p	CLIP-seq
MIRT1021383	hsa-miR-548ab	CLIP-seq
MIRT1021384	hsa-miR-548ak	CLIP-seq
MIRT1021385	hsa-miR-548b-5p	CLIP-seq
MIRT1021386	hsa-miR-548c-5p	CLIP-seq
MIRT1021387	hsa-miR-548d-5p	CLIP-seq
MIRT1021388	hsa-miR-548h	CLIP-seq
MIRT1021389	hsa-miR-548i	CLIP-seq
MIRT1021390	hsa-miR-548j	CLIP-seq
MIRT1021391	hsa-miR-548k	CLIP-seq
MIRT1021392	hsa-miR-548l	CLIP-seq
MIRT1021393	hsa-miR-548w	CLIP-seq
MIRT1021394	hsa-miR-548y	CLIP-seq
MIRT1021395	hsa-miR-559	CLIP-seq
MIRT1021396	hsa-miR-593	CLIP-seq
MIRT1021397	hsa-miR-637	CLIP-seq
MIRT1021398	hsa-miR-647	CLIP-seq
MIRT1021399	hsa-miR-939	CLIP-seq
MIRT2235612	hsa-miR-1301	CLIP-seq
MIRT2235613	hsa-miR-1915	CLIP-seq
MIRT2235614	hsa-miR-3120-5p	CLIP-seq
MIRT2235615	hsa-miR-34a	CLIP-seq
MIRT2235616	hsa-miR-34c-5p	CLIP-seq
MIRT2235617	hsa-miR-3612	CLIP-seq
MIRT2235618	hsa-miR-4459	CLIP-seq
MIRT2235619	hsa-miR-449a	CLIP-seq
MIRT2235620	hsa-miR-449b	CLIP-seq
MIRT2235621	hsa-miR-4641	CLIP-seq
MIRT2235622	hsa-miR-4691-3p	CLIP-seq
MIRT2235623	hsa-miR-4695-5p	CLIP-seq
MIRT2235624	hsa-miR-4726-3p	CLIP-seq
MIRT2235625	hsa-miR-502-5p	CLIP-seq
MIRT2235626	hsa-miR-5047	CLIP-seq
MIRT2235627	hsa-miR-650	CLIP-seq
MIRT2235628	hsa-miR-665	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	8405712
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004967	Function	Glucagon receptor activity	IBA
GO:0004967	Function	Glucagon receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	28514449
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8405712
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	28514449
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	8405712
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	7589461
GO:0007611	Process	Learning or memory	IEA
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0008528	Function	G protein-coupled peptide receptor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8405712
GO:0017046	Function	Peptide hormone binding	IBA
GO:0031204	Process	Post-translational protein targeting to membrane, translocation	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0044508	Function	Glucagon-like peptide 1 receptor activity	IBA
GO:0044508	Function	Glucagon-like peptide 1 receptor activity	IDA	28514449
GO:0045776	Process	Negative regulation of blood pressure	IEA
GO:0045777	Process	Positive regulation of blood pressure	IBA
GO:0045777	Process	Positive regulation of blood pressure	IEA
GO:0046879	Process	Hormone secretion	IEA
GO:0065008	Process	Regulation of biological quality	IEA
GO:0071377	Process	Cellular response to glucagon stimulus	IEA
GO:1990911	Process	Response to psychosocial stress	IEA

MIM	HGNC	e!Ensembl
138032	4324	ENSG00000112164

P43220

Protein name

Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)

Protein function

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that l

PDB

3C59 , 3C5T , 3IOL , 4ZGM , 5E94 , 5NX2 , 5OTT , 5OTU , 5OTV , 5OTW , 5OTX , 5VEW , 5VEX , 6B3J , 6GB1 , 6ORV , 6VCB , 6X18 , 6X19 , 6X1A , 6XOX , 7C2E , 7DUQ , 7DUR , 7E14 , 7EVM , 7FIM , 7KI0 , 7KI1 , 7LCI , 7LCJ , 7LCK , 7LLL , 7LLY , 7RG9 , 7RGP , 7RTB , 7S15 , 7S1M , 7S3I , 7VBH , 7VBI , 7X8R , 7X8S , 8JIP , 8JIR , 8JIS , 8WG7 , 8YW3 , 9IVG , 9IVM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02793	HRM	59 → 129	Hormone receptor domain	Family
PF00002	7tm_2	141 → 398	7 transmembrane receptor (Secretin family)	Family

Sequence

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

Sequence length

463

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Insulin secretion		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production

GLP1R (glucagon like peptide 1 receptor)