Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2739
Gene name Gene Name - the full gene name approved by the HGNC.
Glyoxalase I
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GLO1
Synonyms (NCBI Gene) Gene synonyms aliases
GLOD1, GLYI, HEL-S-74
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016416 hsa-miR-193b-3p Microarray 20304954
MIRT025781 hsa-miR-7-5p Microarray 19073608
MIRT032365 hsa-let-7b-5p Proteomics 18668040
MIRT050980 hsa-miR-17-5p CLASH 23622248
MIRT049258 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004462 Function Lactoylglutathione lyase activity IDA 9705294, 11489834, 20454679, 23122816
GO:0004462 Function Lactoylglutathione lyase activity IEA
GO:0004462 Function Lactoylglutathione lyase activity TAS 7684374
GO:0005515 Function Protein binding IPI 32296183
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138750 4323 ENSG00000124767
Protein
UniProt ID Q04760
Protein name Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)
Protein function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (P
PDB 1BH5 , 1FRO , 1QIN , 1QIP , 3VW9 , 3W0T , 3W0U , 7WSZ , 7WT0 , 7WT1 , 7WT2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00903 Glyoxalase 31 174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Domain
Sequence
Sequence length 184
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pyruvate metabolism
Metabolic pathways
  Pyruvate metabolism
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Autism Autism, susceptibility to, 1 N/A N/A ClinVar
Insomnia Insomnia N/A N/A GWAS
Mental Depression Major depressive disorder N/A N/A GWAS
Otitis media Otitis media N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Albuminuria Associate 18413187
Atherosclerosis Associate 24767709, 27478003
Autistic Disorder Associate 15386471, 17346350
Azoospermia Associate 37283758
Breast Neoplasms Associate 16048908, 19379515, 26618552, 28695773, 36998085
Carcinoma Hepatocellular Associate 31484776
Carcinoma Non Small Cell Lung Associate 20544845
Carcinoma Renal Cell Associate 25407489
Carotid Artery Diseases Inhibit 24767709
Carotid Stenosis Associate 27478003