Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2739
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Glyoxalase I |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
GLO1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
GLOD1, GLYI, HEL-S-74 |
Chromosome
Chromosome number
|
6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6p21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere |
UniProt ID |
Q04760
|
Protein name |
Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) |
Protein function |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (P |
PDB |
1BH5
,
1FRO
,
1QIN
,
1QIP
,
3VW9
,
3W0T
,
3W0U
,
7WSZ
,
7WT0
,
7WT1
,
7WT2
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00903
|
Glyoxalase |
31 → 174 |
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily |
Domain |
|
Sequence |
|
Sequence length |
184 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Autism |
Autistic Disorder |
rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542 View all (8 more) |
15386471 |
Esophagus neoplasm |
Squamous cell carcinoma of esophagus |
rs28934578, rs121918714, rs1567556006, rs1575166666 |
21517111 |
Melanoma |
melanoma |
rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 View all (64 more) |
20093988 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
20530008 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Mental depression |
Mental Depression, Endogenous depression, Depressive disorder, Unipolar Depression, Depressive Syndrome, Depression, Neurotic |
|
18455873, 15858064, 22113448 |
ClinVar |
Mental Depression |
Mental Depression |
|
|
GWAS |
Otitis media |
Otitis media |
|
|
GWAS |
Insomnia |
Insomnia |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Albuminuria |
Associate
|
18413187 |
Atherosclerosis |
Associate
|
24767709, 27478003 |
Autistic Disorder |
Associate
|
15386471, 17346350 |
Azoospermia |
Associate
|
37283758 |
Breast Neoplasms |
Associate
|
16048908, 19379515, 26618552, 28695773, 36998085 |
Carcinoma Hepatocellular |
Associate
|
31484776 |
Carcinoma Non Small Cell Lung |
Associate
|
20544845 |
Carcinoma Renal Cell |
Associate
|
25407489 |
Carotid Artery Diseases |
Inhibit
|
24767709 |
Carotid Stenosis |
Associate
|
27478003 |
Chronic Kidney Disease Mineral and Bone Disorder |
Inhibit
|
29783710 |
Colorectal Neoplasms |
Associate
|
26931562 |
COVID 19 |
Associate
|
37283758 |
Death |
Associate
|
30445774 |
Diabetes Gestational |
Associate
|
38027126 |
Diabetes Mellitus |
Associate
|
18413187, 20093988, 24908234, 29783710, 38027126 |
Diabetes Mellitus Type 1 |
Associate
|
37671166 |
Diabetes Mellitus Type 2 |
Associate
|
18413187 |
Diabetic Nephropathies |
Associate
|
39336582 |
Diabetic Retinopathy |
Associate
|
16505483 |
Drug Related Side Effects and Adverse Reactions |
Associate
|
20093988 |
Encephalitis Herpes Simplex |
Stimulate
|
29783710 |
Endometrial Neoplasms |
Associate
|
21270604, 30849641 |
Fibrosarcoma |
Associate
|
7608125 |
Glioblastoma |
Associate
|
17233837 |
Glioma |
Associate
|
20544845, 33885248 |
Glycosuria Renal |
Associate
|
20544845 |
Hereditary Breast and Ovarian Cancer Syndrome |
Associate
|
20544845 |
Hyperglycemic Hyperosmolar Nonketotic Coma |
Associate
|
16505483 |
Hypoxia |
Associate
|
27999356 |
Inflammation |
Associate
|
24767709, 27898103, 31661534 |
Kidney Neoplasms |
Associate
|
25407489 |
Leukemia |
Associate
|
10807791 |
Lymphatic Metastasis |
Stimulate
|
22479608 |
Melanoma |
Associate
|
20093988 |
Mitochondrial Diseases |
Associate
|
33966051 |
Neoplasm Metastasis |
Stimulate
|
22479608 |
Neoplasm Metastasis |
Associate
|
36998085 |
Neoplasms |
Associate
|
17264672, 19379515, 20093988, 20544845, 22479608, 26618552, 27999356, 28695773, 36450498, 37963646 |
Oligodendroglioma |
Associate
|
17264672 |
Osteoporosis |
Associate
|
30445774, 38364892 |
Pancreatitis Chronic |
Associate
|
31661534 |
Prostatic Neoplasms |
Associate
|
19893039, 24040147, 29504694 |
Renal Insufficiency Chronic |
Associate
|
31924810 |
Sarcoma |
Associate
|
20544845, 35143416 |
Stomach Neoplasms |
Associate
|
20544845, 22479608 |
Thyroid Carcinoma Anaplastic |
Associate
|
31174324 |
Triple Negative Breast Neoplasms |
Associate
|
36998085 |
Urinary Bladder Diseases |
Associate
|
20544845 |
Vascular Diseases |
Associate
|
24908234 |
Vascular System Injuries |
Associate
|
27898103 |
X Linked Combined Immunodeficiency Diseases |
Stimulate
|
29783710 |
|