Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	27347
Gene name	Serine/threonine kinase 39
Gene symbol	STK39
Synonyms (NCBI Gene)	DCHTPASKSPAK
Chromosome	2
Chromosome location	2q24.3
Summary	This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The cat

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miRTarBase ID	miRNA	Experiments
MIRT1398222	hsa-miR-1179	CLIP-seq
MIRT1398223	hsa-miR-1245b-3p	CLIP-seq
MIRT1398224	hsa-miR-1321	CLIP-seq
MIRT1398225	hsa-miR-1827	CLIP-seq
MIRT1398226	hsa-miR-2276	CLIP-seq
MIRT1398227	hsa-miR-2467-3p	CLIP-seq
MIRT1398228	hsa-miR-25	CLIP-seq
MIRT1398229	hsa-miR-2682	CLIP-seq
MIRT1398230	hsa-miR-296-3p	CLIP-seq
MIRT1398231	hsa-miR-3184	CLIP-seq
MIRT1398232	hsa-miR-32	CLIP-seq
MIRT1398233	hsa-miR-363	CLIP-seq
MIRT1398234	hsa-miR-367	CLIP-seq
MIRT1398235	hsa-miR-3689a-3p	CLIP-seq
MIRT1398236	hsa-miR-3689c	CLIP-seq
MIRT1398237	hsa-miR-376c	CLIP-seq
MIRT1398238	hsa-miR-3923	CLIP-seq
MIRT1398239	hsa-miR-3940-5p	CLIP-seq
MIRT1398240	hsa-miR-423-5p	CLIP-seq
MIRT1398241	hsa-miR-4263	CLIP-seq
MIRT1398242	hsa-miR-4317	CLIP-seq
MIRT1398243	hsa-miR-4419a	CLIP-seq
MIRT1398244	hsa-miR-449c	CLIP-seq
MIRT1398245	hsa-miR-4507	CLIP-seq
MIRT1398246	hsa-miR-4510	CLIP-seq
MIRT1398247	hsa-miR-4635	CLIP-seq
MIRT1398248	hsa-miR-4651	CLIP-seq
MIRT1398249	hsa-miR-4696	CLIP-seq
MIRT1398250	hsa-miR-4721	CLIP-seq
MIRT1398251	hsa-miR-4724-3p	CLIP-seq
MIRT1398252	hsa-miR-4728-5p	CLIP-seq
MIRT1398253	hsa-miR-4739	CLIP-seq
MIRT1398254	hsa-miR-4756-5p	CLIP-seq
MIRT1398255	hsa-miR-4775	CLIP-seq
MIRT1398256	hsa-miR-4799-5p	CLIP-seq
MIRT1398257	hsa-miR-4803	CLIP-seq
MIRT1398258	hsa-miR-488	CLIP-seq
MIRT1398259	hsa-miR-5096	CLIP-seq
MIRT1398260	hsa-miR-526b	CLIP-seq
MIRT1398261	hsa-miR-548a-5p	CLIP-seq
MIRT1398262	hsa-miR-548ab	CLIP-seq
MIRT1398263	hsa-miR-548ak	CLIP-seq
MIRT1398264	hsa-miR-548b-5p	CLIP-seq
MIRT1398265	hsa-miR-548c-5p	CLIP-seq
MIRT1398266	hsa-miR-548d-5p	CLIP-seq
MIRT1398267	hsa-miR-548h	CLIP-seq
MIRT1398268	hsa-miR-548i	CLIP-seq
MIRT1398269	hsa-miR-548j	CLIP-seq
MIRT1398270	hsa-miR-548k	CLIP-seq
MIRT1398271	hsa-miR-548l	CLIP-seq
MIRT1398272	hsa-miR-548w	CLIP-seq
MIRT1398273	hsa-miR-548y	CLIP-seq
MIRT1398274	hsa-miR-559	CLIP-seq
MIRT1398275	hsa-miR-576-5p	CLIP-seq
MIRT1398276	hsa-miR-583	CLIP-seq
MIRT1398277	hsa-miR-587	CLIP-seq
MIRT1398278	hsa-miR-608	CLIP-seq
MIRT1398279	hsa-miR-616	CLIP-seq
MIRT1398280	hsa-miR-890	CLIP-seq
MIRT1398281	hsa-miR-92a	CLIP-seq
MIRT1398282	hsa-miR-92b	CLIP-seq
MIRT1554237	hsa-miR-1276	CLIP-seq
MIRT1398226	hsa-miR-2276	CLIP-seq
MIRT1398223	hsa-miR-1245b-3p	CLIP-seq
MIRT1554237	hsa-miR-1276	CLIP-seq
MIRT2119358	hsa-miR-1297	CLIP-seq
MIRT1398224	hsa-miR-1321	CLIP-seq
MIRT2119359	hsa-miR-26a	CLIP-seq
MIRT2119360	hsa-miR-26b	CLIP-seq
MIRT1398230	hsa-miR-296-3p	CLIP-seq
MIRT1398243	hsa-miR-4419a	CLIP-seq
MIRT2119361	hsa-miR-4428	CLIP-seq
MIRT2119362	hsa-miR-4465	CLIP-seq
MIRT1398246	hsa-miR-4510	CLIP-seq
MIRT1398251	hsa-miR-4724-3p	CLIP-seq
MIRT1398252	hsa-miR-4728-5p	CLIP-seq
MIRT1398253	hsa-miR-4739	CLIP-seq
MIRT1398254	hsa-miR-4756-5p	CLIP-seq
MIRT1398258	hsa-miR-488	CLIP-seq
MIRT1398261	hsa-miR-548a-5p	CLIP-seq
MIRT1398262	hsa-miR-548ab	CLIP-seq
MIRT1398263	hsa-miR-548ak	CLIP-seq
MIRT1398264	hsa-miR-548b-5p	CLIP-seq
MIRT1398265	hsa-miR-548c-5p	CLIP-seq
MIRT1398266	hsa-miR-548d-5p	CLIP-seq
MIRT1398267	hsa-miR-548h	CLIP-seq
MIRT1398268	hsa-miR-548i	CLIP-seq
MIRT1398269	hsa-miR-548j	CLIP-seq
MIRT1398270	hsa-miR-548k	CLIP-seq
MIRT1398271	hsa-miR-548l	CLIP-seq
MIRT1398272	hsa-miR-548w	CLIP-seq
MIRT1398273	hsa-miR-548y	CLIP-seq
MIRT1398274	hsa-miR-559	CLIP-seq
MIRT1398276	hsa-miR-583	CLIP-seq
MIRT2119363	hsa-miR-590-3p	CLIP-seq
MIRT1398227	hsa-miR-2467-3p	CLIP-seq
MIRT1398239	hsa-miR-3940-5p	CLIP-seq
MIRT1398245	hsa-miR-4507	CLIP-seq
MIRT1398250	hsa-miR-4721	CLIP-seq
MIRT1398255	hsa-miR-4775	CLIP-seq
MIRT1398258	hsa-miR-488	CLIP-seq
MIRT2341558	hsa-miR-513b	CLIP-seq
MIRT1398271	hsa-miR-548l	CLIP-seq
MIRT1398280	hsa-miR-890	CLIP-seq
MIRT2433645	hsa-miR-340	CLIP-seq
MIRT2460694	hsa-miR-3140-3p	CLIP-seq
MIRT2460695	hsa-miR-323-3p	CLIP-seq
MIRT2460696	hsa-miR-3616-5p	CLIP-seq
MIRT2460697	hsa-miR-3647-5p	CLIP-seq
MIRT2460698	hsa-miR-573	CLIP-seq
MIRT1554237	hsa-miR-1276	CLIP-seq
MIRT2635458	hsa-miR-22	CLIP-seq
MIRT1398226	hsa-miR-2276	CLIP-seq
MIRT2635459	hsa-miR-3123	CLIP-seq
MIRT2460694	hsa-miR-3140-3p	CLIP-seq
MIRT2460695	hsa-miR-323-3p	CLIP-seq
MIRT2433645	hsa-miR-340	CLIP-seq
MIRT2460696	hsa-miR-3616-5p	CLIP-seq
MIRT2460697	hsa-miR-3647-5p	CLIP-seq
MIRT2635460	hsa-miR-3691-5p	CLIP-seq
MIRT2635461	hsa-miR-3925-5p	CLIP-seq
MIRT2635462	hsa-miR-4311	CLIP-seq
MIRT2635463	hsa-miR-4318	CLIP-seq
MIRT2635464	hsa-miR-4422	CLIP-seq
MIRT2635465	hsa-miR-4693-5p	CLIP-seq
MIRT2635466	hsa-miR-4752	CLIP-seq
MIRT2635467	hsa-miR-4769-3p	CLIP-seq
MIRT2635468	hsa-miR-4772-3p	CLIP-seq
MIRT2635469	hsa-miR-4778-5p	CLIP-seq
MIRT2635470	hsa-miR-483-3p	CLIP-seq
MIRT2635471	hsa-miR-544	CLIP-seq
MIRT2635472	hsa-miR-558	CLIP-seq
MIRT2460698	hsa-miR-573	CLIP-seq
MIRT1398276	hsa-miR-583	CLIP-seq
MIRT2635473	hsa-miR-630	CLIP-seq
MIRT2635474	hsa-miR-892a	CLIP-seq
MIRT2635475	hsa-miR-944	CLIP-seq
MIRT1554237	hsa-miR-1276	CLIP-seq
MIRT2635458	hsa-miR-22	CLIP-seq
MIRT2635459	hsa-miR-3123	CLIP-seq
MIRT2460694	hsa-miR-3140-3p	CLIP-seq
MIRT2460695	hsa-miR-323-3p	CLIP-seq
MIRT2460696	hsa-miR-3616-5p	CLIP-seq
MIRT2460697	hsa-miR-3647-5p	CLIP-seq
MIRT2635460	hsa-miR-3691-5p	CLIP-seq
MIRT2635461	hsa-miR-3925-5p	CLIP-seq
MIRT2635462	hsa-miR-4311	CLIP-seq
MIRT2635463	hsa-miR-4318	CLIP-seq
MIRT2635464	hsa-miR-4422	CLIP-seq
MIRT2635465	hsa-miR-4693-5p	CLIP-seq
MIRT2635466	hsa-miR-4752	CLIP-seq
MIRT2635467	hsa-miR-4769-3p	CLIP-seq
MIRT2635472	hsa-miR-558	CLIP-seq
MIRT2460698	hsa-miR-573	CLIP-seq
MIRT1398276	hsa-miR-583	CLIP-seq
MIRT2635474	hsa-miR-892a	CLIP-seq

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Transcription factor	Regulation	Reference
NFKB1	Activation	18787102
RELA	Activation	18787102

Show/Hide all (91)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002021	Process	Response to dietary excess	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	18270262, 19665974, 21321328, 24393035
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	10980603, 16669787
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005515	Function	Protein binding	IPI	16669787, 21423148, 24393035, 24655550
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IMP	10980603
GO:0005829	Component	Cytosol	ISS
GO:0005938	Component	Cell cortex	IEA
GO:0005938	Component	Cell cortex	ISS
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006884	Process	Cell volume homeostasis	IDA	19665974, 21321328
GO:0006884	Process	Cell volume homeostasis	IDA	36318922
GO:0006884	Process	Cell volume homeostasis	IEA
GO:0006884	Process	Cell volume homeostasis	TAS	27782176
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IDA	24393035
GO:0007165	Process	Signal transduction	IMP	16669787
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0010820	Process	Positive regulation of T cell chemotaxis	IBA
GO:0010820	Process	Positive regulation of T cell chemotaxis	IEA
GO:0010820	Process	Positive regulation of T cell chemotaxis	IMP	27400149
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016301	Function	Kinase activity	ISS
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IMP	10980603
GO:0018107	Process	Peptidyl-threonine phosphorylation	IMP	10980603
GO:0019870	Function	Potassium channel inhibitor activity	IDA	24393035
GO:0019901	Function	Protein kinase binding	IEA
GO:0030644	Process	Intracellular chloride ion homeostasis	IEA
GO:0034763	Process	Negative regulation of transmembrane transport	IDA	25531585
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	24393035
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0035865	Process	Cellular response to potassium ion	IEA
GO:0036438	Process	Maintenance of lens transparency	IEA
GO:0036438	Process	Maintenance of lens transparency	ISS
GO:0038146	Process	Chemokine (C-X-C motif) ligand 12 signaling pathway	IEA
GO:0038146	Process	Chemokine (C-X-C motif) ligand 12 signaling pathway	IMP	27400149
GO:0042116	Process	Macrophage activation	IEA
GO:0043268	Process	Positive regulation of potassium ion transport	IEA
GO:0044297	Component	Cell body	IEA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0044325	Function	Transmembrane transporter binding	IPI	24393035
GO:0046777	Process	Protein autophosphorylation	IMP	10980603
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050801	Process	Monoatomic ion homeostasis	IEA
GO:0070294	Process	Renal sodium ion absorption	IDA	18270262
GO:0070294	Process	Renal sodium ion absorption	IDA	18270262
GO:0070294	Process	Renal sodium ion absorption	IEA
GO:0071474	Process	Cellular hyperosmotic response	IBA
GO:0071474	Process	Cellular hyperosmotic response	IDA	36318922
GO:0071474	Process	Cellular hyperosmotic response	IEA
GO:0071476	Process	Cellular hypotonic response	IDA	24393035
GO:0071476	Process	Cellular hypotonic response	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IDA	19665974
GO:0090188	Process	Negative regulation of pancreatic juice secretion	IEA
GO:0099106	Function	Ion channel regulator activity	IMP	16669787
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0141109	Function	Transporter activator activity	IEA
GO:0141109	Function	Transporter activator activity	ISS
GO:0141110	Function	Transporter inhibitor activity	TAS	25531585
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IMP	10980603
GO:1901380	Process	Negative regulation of potassium ion transmembrane transport	IDA	24393035
GO:1901380	Process	Negative regulation of potassium ion transmembrane transport	IEA
GO:1902306	Process	Negative regulation of sodium ion transmembrane transport	IDA	25531585
GO:1903288	Process	Positive regulation of potassium ion import across plasma membrane	IEA
GO:1903288	Process	Positive regulation of potassium ion import across plasma membrane	ISS
GO:1903784	Process	Positive regulation of sodium ion import across plasma membrane	IEA
GO:1903784	Process	Positive regulation of sodium ion import across plasma membrane	ISS
GO:1904044	Process	Response to aldosterone	IEA
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	IEA
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	ISS
GO:1990869	Process	Cellular response to chemokine	IMP	27400149

MIM	HGNC	e!Ensembl
607648	17717	ENSG00000198648

Q9UEW8

Protein name

STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)

Protein function

Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:213

PDB

7O86

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	63 → 337	Protein kinase domain	Domain
PF12202	OSR1_C	452 → 509	Oxidative-stress-responsive kinase 1 C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. {ECO:0000269|PubMed:10980603}.

Sequence

MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR
DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN
VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL
DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA
PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK
EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR
AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS
TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD
GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA
QLSVS

Sequence length

545

Interactions

View interactions

	KEGG
	Parathyroid hormone synthesis, secretion and action

STK39 (serine/threonine kinase 39)