Gene Gene information from NCBI Gene database.
Entrez ID 27342
Gene name RAB guanine nucleotide exchange factor 1
Gene symbol RABGEF1
Synonyms (NCBI Gene)
RABEX5RAP1rabex-5
Chromosome 7
Chromosome location 7q11.21
Summary RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[suppli
miRNA miRNA information provided by mirtarbase database.
471
miRTarBase ID miRNA Experiments Reference
MIRT023256 hsa-miR-122-5p Microarray 17612493
MIRT700311 hsa-miR-6508-5p HITS-CLIP 23313552
MIRT700310 hsa-miR-8067 HITS-CLIP 23313552
MIRT700309 hsa-miR-4795-5p HITS-CLIP 23313552
MIRT700308 hsa-miR-5687 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
GO ID Ontology Definition Evidence Reference
GO:0002686 Process Negative regulation of leukocyte migration IEA
GO:0003677 Function DNA binding IEA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IBA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IDA 11452015, 20937701
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609700 17676 ENSG00000154710
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UJ41
Protein name Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Protein function Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By simila
PDB 1TXU , 2C7M , 2C7N , 2OT3 , 4N3X , 4N3Y , 4N3Z , 4Q9U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01754 zf-A20 17 40 A20-like zinc finger Family
PF18151 DUF5601 158 220 Domain of unknown function (DUF5601) Domain
PF02204 VPS9 268 371 Vacuolar sorting protein 9 (VPS9) domain Family
Sequence
MSLKSERRGIHVDQSDLLCKKGCGYYGNPAWQGFCSKCWREEYHKARQKQIQEDWELAER
LQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGSKKEIQEA
KAPSPSINRQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEGMHYKRDLSIEEQSE
CAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLY
KYVFCPETTDDEKKDLAIQK
RIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFN
AIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLC
CAVAFIEKLDA
QSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLLSQL
NERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVENDKL
PPPLQPQVYAG
Sequence length 491
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal   TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs