RABGEF1 (RAB guanine nucleotide exchange factor 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 27342 |
| Gene name | RAB guanine nucleotide exchange factor 1 |
| Gene symbol | RABGEF1 |
| Synonyms (NCBI Gene) |
RABEX5RAP1rabex-5
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| Chromosome | 7 |
| Chromosome location | 7q11.21 |
| Summary | RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[suppli |
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miRNA
miRNA information provided by mirtarbase database.
471
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UJ41 | ||||||||||||||||||||
| Protein name | Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5) | ||||||||||||||||||||
| Protein function | Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By simila | ||||||||||||||||||||
| PDB | 1TXU , 2C7M , 2C7N , 2OT3 , 4N3X , 4N3Y , 4N3Z , 4Q9U | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 491 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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