Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27340
Gene name Gene Name - the full gene name approved by the HGNC.	UTP20 small subunit processome component
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UTP20
Synonyms (NCBI Gene) Gene synonyms aliases	1A6/DRIM, DRIM
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q23.2
Summary Summary of gene provided in NCBI Entrez Gene.	UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]

Show/Hide all(190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027738	hsa-miR-98-5p	Microarray	19088304
MIRT031895	hsa-miR-16-5p	Proteomics	18668040
MIRT035836	hsa-miR-1276	CLASH	23622248
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT649748	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT649748	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT649748	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT649748	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT616004	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT616003	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT612004	hsa-miR-614	HITS-CLIP	23824327
MIRT612003	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612002	hsa-miR-1281	HITS-CLIP	23824327
MIRT612001	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT612000	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT611999	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT611998	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT1481201	hsa-miR-1228	CLIP-seq
MIRT1481202	hsa-miR-1283	CLIP-seq
MIRT1481203	hsa-miR-24	CLIP-seq
MIRT1481204	hsa-miR-342-3p	CLIP-seq
MIRT1481205	hsa-miR-3614-5p	CLIP-seq
MIRT1481206	hsa-miR-3689a-3p	CLIP-seq
MIRT1481207	hsa-miR-3689c	CLIP-seq
MIRT1481208	hsa-miR-371-5p	CLIP-seq
MIRT1481209	hsa-miR-3926	CLIP-seq
MIRT1481210	hsa-miR-3929	CLIP-seq
MIRT1481211	hsa-miR-4255	CLIP-seq
MIRT1481212	hsa-miR-4284	CLIP-seq
MIRT1481213	hsa-miR-4419b	CLIP-seq
MIRT1481214	hsa-miR-4468	CLIP-seq
MIRT1481215	hsa-miR-4478	CLIP-seq
MIRT1481216	hsa-miR-4728-5p	CLIP-seq
MIRT1481217	hsa-miR-4786-5p	CLIP-seq
MIRT1481218	hsa-miR-4797-5p	CLIP-seq
MIRT1481219	hsa-miR-485-5p	CLIP-seq
MIRT1481220	hsa-miR-542-3p	CLIP-seq
MIRT1481221	hsa-miR-548s	CLIP-seq
MIRT1481222	hsa-miR-759	CLIP-seq
MIRT1481223	hsa-miR-769-5p	CLIP-seq
MIRT1481224	hsa-miR-890	CLIP-seq
MIRT2144776	hsa-miR-3180-5p	CLIP-seq
MIRT1481209	hsa-miR-3926	CLIP-seq
MIRT2144777	hsa-miR-3942-3p	CLIP-seq
MIRT2144778	hsa-miR-4494	CLIP-seq
MIRT1481217	hsa-miR-4786-5p	CLIP-seq
MIRT2144779	hsa-miR-499a-5p	CLIP-seq
MIRT2144780	hsa-miR-520a-5p	CLIP-seq
MIRT2144781	hsa-miR-525-5p	CLIP-seq
MIRT1481221	hsa-miR-548s	CLIP-seq
MIRT2365115	hsa-miR-1304	CLIP-seq
MIRT2365116	hsa-miR-2467-5p	CLIP-seq
MIRT2365117	hsa-miR-2964a-5p	CLIP-seq
MIRT2365118	hsa-miR-3160-3p	CLIP-seq
MIRT2365119	hsa-miR-3188	CLIP-seq
MIRT2144777	hsa-miR-3942-3p	CLIP-seq
MIRT2365120	hsa-miR-3975	CLIP-seq
MIRT2365121	hsa-miR-4487	CLIP-seq
MIRT2144778	hsa-miR-4494	CLIP-seq
MIRT2365122	hsa-miR-4679	CLIP-seq
MIRT2365123	hsa-miR-4726-3p	CLIP-seq
MIRT1481219	hsa-miR-485-5p	CLIP-seq
MIRT2144779	hsa-miR-499a-5p	CLIP-seq
MIRT2365124	hsa-miR-558	CLIP-seq
MIRT2658895	hsa-miR-1225-3p	CLIP-seq
MIRT1481201	hsa-miR-1228	CLIP-seq
MIRT2658896	hsa-miR-1233	CLIP-seq
MIRT1481202	hsa-miR-1283	CLIP-seq
MIRT2658897	hsa-miR-1827	CLIP-seq
MIRT2658898	hsa-miR-3122	CLIP-seq
MIRT1481206	hsa-miR-3689a-3p	CLIP-seq
MIRT1481207	hsa-miR-3689c	CLIP-seq
MIRT1481208	hsa-miR-371-5p	CLIP-seq
MIRT2658899	hsa-miR-3913-5p	CLIP-seq
MIRT1481209	hsa-miR-3926	CLIP-seq
MIRT2658900	hsa-miR-3934	CLIP-seq
MIRT2658901	hsa-miR-3937	CLIP-seq
MIRT2365123	hsa-miR-4726-3p	CLIP-seq
MIRT1481216	hsa-miR-4728-5p	CLIP-seq
MIRT1481217	hsa-miR-4786-5p	CLIP-seq
MIRT1481218	hsa-miR-4797-5p	CLIP-seq
MIRT1481221	hsa-miR-548s	CLIP-seq
MIRT1481222	hsa-miR-759	CLIP-seq
MIRT1481223	hsa-miR-769-5p	CLIP-seq
MIRT2658902	hsa-miR-940	CLIP-seq
MIRT2658895	hsa-miR-1225-3p	CLIP-seq
MIRT1481201	hsa-miR-1228	CLIP-seq
MIRT2658896	hsa-miR-1233	CLIP-seq
MIRT1481202	hsa-miR-1283	CLIP-seq
MIRT2658897	hsa-miR-1827	CLIP-seq
MIRT2658898	hsa-miR-3122	CLIP-seq
MIRT1481206	hsa-miR-3689a-3p	CLIP-seq
MIRT1481207	hsa-miR-3689c	CLIP-seq
MIRT1481208	hsa-miR-371-5p	CLIP-seq
MIRT2658899	hsa-miR-3913-5p	CLIP-seq
MIRT1481209	hsa-miR-3926	CLIP-seq
MIRT2658900	hsa-miR-3934	CLIP-seq
MIRT2658901	hsa-miR-3937	CLIP-seq
MIRT2365123	hsa-miR-4726-3p	CLIP-seq
MIRT1481216	hsa-miR-4728-5p	CLIP-seq
MIRT1481217	hsa-miR-4786-5p	CLIP-seq
MIRT1481218	hsa-miR-4797-5p	CLIP-seq
MIRT1481221	hsa-miR-548s	CLIP-seq
MIRT1481222	hsa-miR-759	CLIP-seq
MIRT1481223	hsa-miR-769-5p	CLIP-seq
MIRT2658902	hsa-miR-940	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS	15590835
GO:0000472	Process	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS	17652137
GO:0000480	Process	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS	17652137
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16053918, 17498821
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	ISS	17652137
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	16458307
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	ISS	15590835
GO:0005737	Component	Cytoplasm	ISS	17652137
GO:0005886	Component	Plasma membrane	IDA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	17498821
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9673349
GO:0030686	Component	90S preribosome	IBA
GO:0030686	Component	90S preribosome	ISS	12150911
GO:0030688	Component	Preribosome, small subunit precursor	ISS	17652137
GO:0032040	Component	Small-subunit processome	IBA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032040	Component	Small-subunit processome	ISS	15590835
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797

MIM	HGNC	e!Ensembl
612822	17897	ENSG00000120800

Protein

UniProt ID

O75691

Protein name

Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6)

Protein function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associat

PDB

7MQ8 , 7MQ9 , 7MQA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07539	DRIM	909 → 1534	Down-regulated in metastasis	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. {ECO:0000269|PubMed:9673349}.

Sequence

MKTKPVSHKTENTYRFLTFAERLGNVNIDIIHRIDRTASYEEEVETYFFEGLLKWRELNL
TEHFGKFYKEVIDKCQSFNQLVYHQNEIVQSLKTHLQVKNSFAYQPLLDLVVQLARDLQM
DFYPHFPEFFLTITSILETQDTELLEWAFTSLSYLYKYLWRLMVKDMSSIYSMYSTLLAH
KKLHIRNFAAESFTFLMRKVSDKNALFNLMFLDLDKHPEKVEGVGQLLFEMCKGVRNMFH
SCTGQAVKLILRKLGPVTETETQLPWMLIGETLKNMVKSTVSYISKEHFGTFFECLQESL
LDLHTKVTKTNCCESSEQIKRLLETYLILVKHGSGTKIPTPADVCKVLSQTLQVASLSTS
CWETLLDVISALILGENVSLPETLIKETIEKIFESRFEKRLIFSFSEVMFAMKQFEQLFL
PSFLSYIVNCFLIDDAVVKDEALAILAKLILNKAAPPTAGSMAIEKYPLVFSPQMVGFYI
KQKKTRSKGRNEQFPVLDHLLSIIKLPPNKDTTYLSQSWAALVVLPHIRPLEKEKVIPLV
TGFIEALFMTVDKGSFGKGNLFVLCQAVNTLLSLEESSELLHLVPVERVKNLVLTFPLEP
SVLLLTDLYYQRLALCGCKGPLSQEALMELFPKLQANISTGVSKIRLLTIRILNHFDVQL
PESMEDDGLSERQSVFAILRQAELVPATVNDYREKLLHLRKLRHDVVQTAVPDGPLQEVP
LRYLLGMLYINFSALWDPVIELISSHAHEMENKQFWKVYYEHLEKAATHAEKELQNDMTD
EKSVGDESWEQTQEGDVGALYHEQLALKTDCQERLDHTNFRFLLWRALTKFPERVEPRSR
ELSPLFLRFINNEYYPADLQVAPTQDLRRKGKGMVAEEIEEEPAAGDDEELEEEAVPQDE
SSQKKKTRRAAAKQLIAHLQVFSKFSNPRALYLESKLYELYLQLLLHQDQMVQKITLDCI
MTYKHPHVLPYRENLQRLLEDRSFKEEIVHFSISEDNAVVKTAHRADLFPILMRILYGRM
KNKTGSKTQGKSASGTRMAIVLRFLAGTQPEEIQIFLDLLFEPVRHFKNGECHSAVIQAV
EDLDLSKVLPLGRQHGILNSLEIVLKNISHLISAYLPKILQILLCMTATVSHILDQREKI
QLRFINPLKNLRRLGIKMVTDIFLDWESYQFRTEEIDAVFHGAVWPQISRLGSESQYSPT
PLLKLISIWSRNARYFPLLAKQKPGHPECDILTNVFAILSAKNLSDATASIVMDIVDDLL
NLPDFEPTETVLNLLVTGCVYPGIAENIGESITIGGRLILPHVPAILQYLSKTTISAEKV
KKKKNRAQVSKELGILSKISKFMKDKEQSSVLITLLLPFLHRGNIAEDTEVDILVTVQNL
LKHCVDPTSFLKPIAKLFSVIKNKLSRKLLCTVFETLSDFESGLKYITDVVKLNAFDQRH
LDDINFDVRFETFQTITSYIKEMQIVDVNYLIPVMHNCFYNLELGDMSLSDNASMCLMSI
IKKLAALNVTEKDYREIIHRSLLEKLRKGLKSQTESIQQDYTTILSCLIQTFPNQLEFKD
LVQLTHYHDPEMDFFENMKHIQIHRRARALKKLAKQLMEGKVVLSSKSLQNYIMPYAMTP
IFDEKMLKHENITTAATEIIGAICKHLSWSAYMYYLKHFIHVLQTGQINQKLGVSLLVIV
LEAFHFDHKTLEEQMGKIENEENAIEAIELPEPEAMELERVDEEEKEYTCKSLSDNGQPG
TPDPADSGGTSAKESECITKPVSFLPQNKEEIERTIKNIQGTITGDILPRLHKCLASTTK
REEEHKLVKSKVVNDEEVVRVPLAFAMVKLMQSLPQEVMEANLPSILLKVCALLKNRAQE
IRDIARSTLAKIIEDLGVHFLLYVLKELQTTLVRGYQVHVLTFTVHMLLQGLTNKLQVGD
LDSCLDIMIEIFNHELFGAVAEEKEVKQILSKVMEARRSKSYDSYEILGKFVGKDQVTKL
ILPLKEILQNTTSLKLARKVHETLRRITVGLIVNQEMTAESILLLSYGLISENLPLLTEK
EKNPVAPAPDPRLPPQSCLLLPPTPVRGGQKAVVSRKTNMHIFIESGLRLLHLSLKTSKI
KSSGECVLEMLDPFVSLLIDCLGSMDVKVITGALQCLIWVLRFPLPSIETKAEQLTKHLF
LLLKDYAKLGAARGQNFHLVVNCFKCVTILVKKVKSYQITEKQLQVLLAYAEEDIYDTSR
QATAFGLLKAILSRKLLVPEIDEVMRKVSKLAVSAQSEPARVQCRQVFLKYILDYPLGDK
LRPNLEFMLAQLNYEHETGRESTLEMIAYLFDTFPQGLLHENCGMFFIPLCLMTINDDSA
TCKKMASMTIKSLLGKISLEKKDWLFDMVTTWFGAKKRLNRQLAALICGLFVESEGVDFE
KRLGTVLPVIEKEIDPENFKDIMEETEEKAADRLLFSFLTLITKLIKECNIIQFTKPAET
LSKIWSHVHSHLRHPHNWVWLTAAQIFGLLFASCQPEELIQKWNTKKTKKHLPEPVAIKF
LASDLDQKMKSISLASCHQLHSKFLDQSLGEQVVKNLLFAAKVLYLLELYCEDKQSKIKE
DLEEQEALEDGVACADEKAESDGEEKEEVKEELGRPATLLWLIQKLSRIAKLEAAYSPRN
PLKRTCIFKFLGAVAMDLGIDKVKPYLPMIIAPLFRELNSTYSEQDPLLKNLSQEIIELL
KKLVGLESFSLAFASVQKQANEKRALRKKRKALEFVTNPDIAAKKKMKKHKNKSEAKKRK
IEFLRPGYKAKRQKSHSLKDLAMVE

Sequence length

2785

Interactions

View interactions

	Reactome
			Major pathway of rRNA processing in the nucleolus and cytosol

UTP20 (UTP20 small subunit processome component)