PCDH11X (protocadherin 11 X-linked)

Gene

• Entrez ID: 27328
• Gene name: Protocadherin 11 X-linked
• Gene symbol: PCDH11X
• Synonyms (NCBI Gene): PCDH-X, PCDH-Y, PCDH11, PCDH11Y, PCDH22, PCDHX, PPP1R119
• Chromosome: X
• Chromosome location: Xq21.31
• Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT645608	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT645607	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT645606	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT645605	hsa-miR-4775	HITS-CLIP	23824327
MIRT645604	hsa-miR-432-3p	HITS-CLIP	23824327
MIRT569272	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT569271	hsa-miR-5694	PAR-CLIP	20371350
MIRT569270	hsa-miR-2115-3p	PAR-CLIP	20371350
MIRT569269	hsa-miR-3935	PAR-CLIP	20371350
MIRT569268	hsa-miR-376a-2-5p	PAR-CLIP	20371350
MIRT569266	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569267	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT569272	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT569271	hsa-miR-5694	PAR-CLIP	20371350
MIRT569270	hsa-miR-2115-3p	PAR-CLIP	20371350
MIRT569269	hsa-miR-3935	PAR-CLIP	20371350
MIRT569268	hsa-miR-376a-2-5p	PAR-CLIP	20371350
MIRT569266	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569267	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT645608	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT645607	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT645606	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT645605	hsa-miR-4775	HITS-CLIP	23824327
MIRT645604	hsa-miR-432-3p	HITS-CLIP	23824327
MIRT569272	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT569271	hsa-miR-5694	PAR-CLIP	20371350
MIRT569270	hsa-miR-2115-3p	PAR-CLIP	20371350
MIRT569269	hsa-miR-3935	PAR-CLIP	20371350
MIRT569268	hsa-miR-376a-2-5p	PAR-CLIP	20371350
MIRT569266	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569267	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT569272	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT569271	hsa-miR-5694	PAR-CLIP	20371350
MIRT569270	hsa-miR-2115-3p	PAR-CLIP	20371350
MIRT569269	hsa-miR-3935	PAR-CLIP	20371350
MIRT569268	hsa-miR-376a-2-5p	PAR-CLIP	20371350
MIRT569266	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569267	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT1216630	hsa-miR-1228	CLIP-seq
MIRT1216631	hsa-miR-1245b-3p	CLIP-seq
MIRT1216632	hsa-miR-1321	CLIP-seq
MIRT1216633	hsa-miR-297	CLIP-seq
MIRT1216634	hsa-miR-3149	CLIP-seq
MIRT1216635	hsa-miR-3162-5p	CLIP-seq
MIRT1216636	hsa-miR-329	CLIP-seq
MIRT1216637	hsa-miR-362-3p	CLIP-seq
MIRT1216638	hsa-miR-377	CLIP-seq
MIRT1216639	hsa-miR-3941	CLIP-seq
MIRT1216640	hsa-miR-3942-3p	CLIP-seq
MIRT1216641	hsa-miR-450b-3p	CLIP-seq
MIRT1216642	hsa-miR-452	CLIP-seq
MIRT1216643	hsa-miR-4676-3p	CLIP-seq
MIRT1216644	hsa-miR-4724-5p	CLIP-seq
MIRT1216645	hsa-miR-4739	CLIP-seq
MIRT1216646	hsa-miR-4756-5p	CLIP-seq
MIRT1216647	hsa-miR-4789-5p	CLIP-seq
MIRT1216648	hsa-miR-513a-3p	CLIP-seq
MIRT1216649	hsa-miR-596	CLIP-seq
MIRT1216650	hsa-miR-603	CLIP-seq
MIRT1216651	hsa-miR-769-3p	CLIP-seq
MIRT1216652	hsa-miR-9	CLIP-seq
MIRT1216653	hsa-miR-1298	CLIP-seq
MIRT1216654	hsa-miR-326	CLIP-seq
MIRT1216655	hsa-miR-330-5p	CLIP-seq
MIRT1216656	hsa-miR-769-5p	CLIP-seq
MIRT1216657	hsa-miR-106a	CLIP-seq
MIRT1216658	hsa-miR-106b	CLIP-seq
MIRT1216659	hsa-miR-122	CLIP-seq
MIRT1216660	hsa-miR-1224-3p	CLIP-seq
MIRT1216661	hsa-miR-1234	CLIP-seq
MIRT1216662	hsa-miR-125a-3p	CLIP-seq
MIRT1216663	hsa-miR-1307	CLIP-seq
MIRT1216664	hsa-miR-150	CLIP-seq
MIRT1216665	hsa-miR-17	CLIP-seq
MIRT1216666	hsa-miR-20a	CLIP-seq
MIRT1216667	hsa-miR-20b	CLIP-seq
MIRT1216668	hsa-miR-218	CLIP-seq
MIRT1216669	hsa-miR-302a	CLIP-seq
MIRT1216670	hsa-miR-302b	CLIP-seq
MIRT1216671	hsa-miR-302c	CLIP-seq
MIRT1216672	hsa-miR-302d	CLIP-seq
MIRT1216673	hsa-miR-302e	CLIP-seq
MIRT1216674	hsa-miR-3135b	CLIP-seq
MIRT1216675	hsa-miR-3545-3p	CLIP-seq
MIRT1216676	hsa-miR-3652	CLIP-seq
MIRT1216677	hsa-miR-3664-5p	CLIP-seq
MIRT1216678	hsa-miR-372	CLIP-seq
MIRT1216679	hsa-miR-373	CLIP-seq
MIRT1216680	hsa-miR-3934	CLIP-seq
MIRT1216681	hsa-miR-4284	CLIP-seq
MIRT1216682	hsa-miR-4430	CLIP-seq
MIRT1216683	hsa-miR-4638-5p	CLIP-seq
MIRT1216684	hsa-miR-4680-5p	CLIP-seq
MIRT1216685	hsa-miR-4714-5p	CLIP-seq
MIRT1216686	hsa-miR-4731-5p	CLIP-seq
MIRT1216687	hsa-miR-4793-3p	CLIP-seq
MIRT1216688	hsa-miR-5095	CLIP-seq
MIRT1216689	hsa-miR-512-3p	CLIP-seq
MIRT1216690	hsa-miR-519d	CLIP-seq
MIRT1216691	hsa-miR-520a-3p	CLIP-seq
MIRT1216692	hsa-miR-520b	CLIP-seq
MIRT1216693	hsa-miR-520c-3p	CLIP-seq
MIRT1216694	hsa-miR-520d-3p	CLIP-seq
MIRT1216695	hsa-miR-520e	CLIP-seq
MIRT1216696	hsa-miR-520g	CLIP-seq
MIRT1216697	hsa-miR-520h	CLIP-seq
MIRT1216698	hsa-miR-552	CLIP-seq
MIRT1216699	hsa-miR-566	CLIP-seq
MIRT1216700	hsa-miR-640	CLIP-seq
MIRT1216701	hsa-miR-764	CLIP-seq
MIRT1216702	hsa-miR-93	CLIP-seq
MIRT2290930	hsa-miR-1272	CLIP-seq
MIRT2290931	hsa-miR-1276	CLIP-seq
MIRT2290932	hsa-miR-1296	CLIP-seq
MIRT2290933	hsa-miR-137	CLIP-seq
MIRT2290934	hsa-miR-2277-3p	CLIP-seq
MIRT2290935	hsa-miR-25	CLIP-seq
MIRT2290936	hsa-miR-2909	CLIP-seq
MIRT2290937	hsa-miR-3065-5p	CLIP-seq
MIRT2290938	hsa-miR-3182	CLIP-seq
MIRT2290939	hsa-miR-32	CLIP-seq
MIRT2290940	hsa-miR-3613-3p	CLIP-seq
MIRT2290941	hsa-miR-363	CLIP-seq
MIRT2290942	hsa-miR-367	CLIP-seq
MIRT2290943	hsa-miR-3682-3p	CLIP-seq
MIRT2290944	hsa-miR-4311	CLIP-seq
MIRT2290945	hsa-miR-4325	CLIP-seq
MIRT2290946	hsa-miR-4436b-3p	CLIP-seq
MIRT2290947	hsa-miR-4636	CLIP-seq
MIRT1216684	hsa-miR-4680-5p	CLIP-seq
MIRT2290948	hsa-miR-4711-3p	CLIP-seq
MIRT2290949	hsa-miR-4744	CLIP-seq
MIRT2290950	hsa-miR-4761-3p	CLIP-seq
MIRT2290951	hsa-miR-548ac	CLIP-seq
MIRT2290952	hsa-miR-548ae	CLIP-seq
MIRT2290953	hsa-miR-548aj	CLIP-seq
MIRT2290954	hsa-miR-548am	CLIP-seq
MIRT2290955	hsa-miR-548d-3p	CLIP-seq
MIRT2290956	hsa-miR-548x	CLIP-seq
MIRT2290957	hsa-miR-548z	CLIP-seq
MIRT2290958	hsa-miR-570	CLIP-seq
MIRT2290959	hsa-miR-583	CLIP-seq
MIRT2290960	hsa-miR-618	CLIP-seq
MIRT2290961	hsa-miR-922	CLIP-seq
MIRT2290962	hsa-miR-92a	CLIP-seq
MIRT2290963	hsa-miR-92b	CLIP-seq
MIRT2392186	hsa-miR-1281	CLIP-seq
MIRT1216663	hsa-miR-1307	CLIP-seq
MIRT2392187	hsa-miR-2052	CLIP-seq
MIRT2392188	hsa-miR-2276	CLIP-seq
MIRT2392189	hsa-miR-4279	CLIP-seq
MIRT1216681	hsa-miR-4284	CLIP-seq
MIRT2392190	hsa-miR-4532	CLIP-seq
MIRT1216683	hsa-miR-4638-5p	CLIP-seq
MIRT1216699	hsa-miR-566	CLIP-seq
MIRT2392191	hsa-miR-659	CLIP-seq
MIRT1216657	hsa-miR-106a	CLIP-seq
MIRT1216658	hsa-miR-106b	CLIP-seq
MIRT1216659	hsa-miR-122	CLIP-seq
MIRT1216660	hsa-miR-1224-3p	CLIP-seq
MIRT1216661	hsa-miR-1234	CLIP-seq
MIRT1216662	hsa-miR-125a-3p	CLIP-seq
MIRT2588583	hsa-miR-1270	CLIP-seq
MIRT2588584	hsa-miR-1273f	CLIP-seq
MIRT2392186	hsa-miR-1281	CLIP-seq
MIRT2588585	hsa-miR-129-5p	CLIP-seq
MIRT1216663	hsa-miR-1307	CLIP-seq
MIRT1216664	hsa-miR-150	CLIP-seq
MIRT1216665	hsa-miR-17	CLIP-seq
MIRT1216666	hsa-miR-20a	CLIP-seq
MIRT1216667	hsa-miR-20b	CLIP-seq
MIRT2392188	hsa-miR-2276	CLIP-seq
MIRT1216669	hsa-miR-302a	CLIP-seq
MIRT1216670	hsa-miR-302b	CLIP-seq
MIRT1216671	hsa-miR-302c	CLIP-seq
MIRT1216672	hsa-miR-302d	CLIP-seq
MIRT1216673	hsa-miR-302e	CLIP-seq
MIRT1216674	hsa-miR-3135b	CLIP-seq
MIRT1216634	hsa-miR-3149	CLIP-seq
MIRT2588586	hsa-miR-3591-5p	CLIP-seq
MIRT1216676	hsa-miR-3652	CLIP-seq
MIRT2588587	hsa-miR-3658	CLIP-seq
MIRT2588588	hsa-miR-3681	CLIP-seq
MIRT1216678	hsa-miR-372	CLIP-seq
MIRT1216679	hsa-miR-373	CLIP-seq
MIRT2588589	hsa-miR-3913-3p	CLIP-seq
MIRT1216680	hsa-miR-3934	CLIP-seq
MIRT2588590	hsa-miR-4258	CLIP-seq
MIRT1216681	hsa-miR-4284	CLIP-seq
MIRT2588591	hsa-miR-4426	CLIP-seq
MIRT1216682	hsa-miR-4430	CLIP-seq
MIRT2588592	hsa-miR-4460	CLIP-seq
MIRT2392190	hsa-miR-4532	CLIP-seq
MIRT1216683	hsa-miR-4638-5p	CLIP-seq
MIRT2588593	hsa-miR-4647	CLIP-seq
MIRT2588594	hsa-miR-4662b	CLIP-seq
MIRT2588595	hsa-miR-4683	CLIP-seq
MIRT2588596	hsa-miR-4707-3p	CLIP-seq
MIRT2588597	hsa-miR-4727-3p	CLIP-seq
MIRT1216686	hsa-miR-4731-5p	CLIP-seq
MIRT2588598	hsa-miR-4735-5p	CLIP-seq
MIRT2588599	hsa-miR-4755-3p	CLIP-seq
MIRT1216689	hsa-miR-512-3p	CLIP-seq
MIRT1216690	hsa-miR-519d	CLIP-seq
MIRT1216691	hsa-miR-520a-3p	CLIP-seq
MIRT1216692	hsa-miR-520b	CLIP-seq
MIRT1216693	hsa-miR-520c-3p	CLIP-seq
MIRT1216694	hsa-miR-520d-3p	CLIP-seq
MIRT1216695	hsa-miR-520e	CLIP-seq
MIRT1216696	hsa-miR-520g	CLIP-seq
MIRT1216697	hsa-miR-520h	CLIP-seq
MIRT1216699	hsa-miR-566	CLIP-seq
MIRT2588600	hsa-miR-620	CLIP-seq
MIRT1216700	hsa-miR-640	CLIP-seq
MIRT1216701	hsa-miR-764	CLIP-seq
MIRT1216702	hsa-miR-93	CLIP-seq
MIRT1216657	hsa-miR-106a	CLIP-seq
MIRT1216658	hsa-miR-106b	CLIP-seq
MIRT1216659	hsa-miR-122	CLIP-seq
MIRT1216660	hsa-miR-1224-3p	CLIP-seq
MIRT1216661	hsa-miR-1234	CLIP-seq
MIRT1216662	hsa-miR-125a-3p	CLIP-seq
MIRT2392186	hsa-miR-1281	CLIP-seq
MIRT2588585	hsa-miR-129-5p	CLIP-seq
MIRT1216663	hsa-miR-1307	CLIP-seq
MIRT1216664	hsa-miR-150	CLIP-seq
MIRT1216665	hsa-miR-17	CLIP-seq
MIRT1216666	hsa-miR-20a	CLIP-seq
MIRT1216667	hsa-miR-20b	CLIP-seq
MIRT2392188	hsa-miR-2276	CLIP-seq
MIRT1216669	hsa-miR-302a	CLIP-seq
MIRT1216670	hsa-miR-302b	CLIP-seq
MIRT1216671	hsa-miR-302c	CLIP-seq
MIRT1216672	hsa-miR-302d	CLIP-seq
MIRT1216673	hsa-miR-302e	CLIP-seq
MIRT1216674	hsa-miR-3135b	CLIP-seq
MIRT1216676	hsa-miR-3652	CLIP-seq
MIRT1216678	hsa-miR-372	CLIP-seq
MIRT1216679	hsa-miR-373	CLIP-seq
MIRT1216680	hsa-miR-3934	CLIP-seq
MIRT1216681	hsa-miR-4284	CLIP-seq
MIRT1216682	hsa-miR-4430	CLIP-seq
MIRT1216683	hsa-miR-4638-5p	CLIP-seq
MIRT1216686	hsa-miR-4731-5p	CLIP-seq
MIRT1216688	hsa-miR-5095	CLIP-seq
MIRT1216689	hsa-miR-512-3p	CLIP-seq
MIRT1216690	hsa-miR-519d	CLIP-seq
MIRT1216691	hsa-miR-520a-3p	CLIP-seq
MIRT1216692	hsa-miR-520b	CLIP-seq
MIRT1216693	hsa-miR-520c-3p	CLIP-seq
MIRT1216694	hsa-miR-520d-3p	CLIP-seq
MIRT1216695	hsa-miR-520e	CLIP-seq
MIRT1216696	hsa-miR-520g	CLIP-seq
MIRT1216697	hsa-miR-520h	CLIP-seq
MIRT1216699	hsa-miR-566	CLIP-seq
MIRT1216700	hsa-miR-640	CLIP-seq
MIRT1216701	hsa-miR-764	CLIP-seq
MIRT1216702	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10644456
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0016020	Component	Membrane	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 300246
• HGNC: 8656
• e!Ensembl: ENSG00000102290

Protein

• UniProt ID: Q9BZA7
• Protein name: Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)
• Protein function: Potential calcium-dependent cell-adhesion protein.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08266	Cadherin_2	25 → 115	Cadherin-like	Domain
  PF00028	Cadherin	144 → 240	Cadherin domain	Domain
  PF00028	Cadherin	254 → 346	Cadherin domain	Domain
  PF00028	Cadherin	366 → 457	Cadherin domain	Domain
  PF00028	Cadherin	471 → 561	Cadherin domain	Domain
  PF00028	Cadherin	575 → 664	Cadherin domain	Domain
  PF00028	Cadherin	682 → 773	Cadherin domain	Domain
  PF08374	Protocadherin	775 → 998	Protocadherin	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. {ECO:0000269|PubMed:10644456, ECO:0000269|PubMed:11003707}.
• Sequence:

  MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA
  MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIF
  RLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK
  SQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT
  DTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLF
  HLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYI
  VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLET
  AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNS
  PGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI
  LAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYG
  DNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVT
  INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNT
  RDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNAT
  LINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAP
  HLKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDG
  NRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKH
  HIIQELPLDNTFVACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPPMKEVVRSC
  TPMKESTTMEIWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTS
  TSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDNCT
  QECLIYGHSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSPRVTQTIALCHSPP
  VTQTIALCHSPPPIQVSALHHSPPLVQATALHHSPPSAQASALCYSPPLAQAAAISHSSP
  LPQVIALHRSQAQSSVSLQQGWVQGADGLCSVDQGVQGSATSQFYTMSERLHPSDDSIKV
  IPLTTFTPRQQARPSRGDSPIMEEHPL

• Sequence length: 1347

Pathways

KEGG:

Virion - Lassa virus and SFTS virus

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Alzheimer disease	Likely benign	rs781770086	RCV000590975
PCDH11X-related disorder	Uncertain significance	rs2521055275	RCV003402922

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	19136949, 26680604
Autistic Disorder	Associate	16331680
Leiomyoma	Associate	21685710
Primary Ovarian Insufficiency	Associate	21316664