HPGDS (hematopoietic prostaglandin D synthase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27306
Gene name Gene Name - the full gene name approved by the HGNC.
Hematopoietic prostaglandin D synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HPGDS
Synonyms (NCBI Gene) Gene synonyms aliases
GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can b
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
miRTarBase ID miRNA Experiments Reference
MIRT1054141 hsa-miR-3128 CLIP-seq
MIRT1054142 hsa-miR-3150a-3p CLIP-seq
MIRT1054143 hsa-miR-3175 CLIP-seq
MIRT1054144 hsa-miR-34a CLIP-seq
MIRT1054145 hsa-miR-34c-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
POU2F1 Unknown 10998423
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 12627223
GO:0004364 Function Glutathione transferase activity IBA 21873635
GO:0004667 Function Prostaglandin-D synthase activity IDA 12627223
GO:0005509 Function Calcium ion binding IDA 12627223
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602598 17890 ENSG00000163106
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O60760
Protein name Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)
Protein function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of ary
PDB 1IYH , 1IYI , 1V40 , 2CVD , 2VCQ , 2VCW , 2VCX , 2VCZ , 2VD0 , 2VD1 , 3EE2 , 3KXO , 3VI5 , 3VI7 , 4EC0 , 4EDY , 4EDZ , 4EE0 , 5AIS , 5AIV , 5AIX , 5YWE , 5YWX , 5YX1 , 6N4E , 6W58 , 6W8H , 6ZTC , 7JR6 , 7JR8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 4 → 73 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 92 → 194 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {
Sequence
Sequence length 199
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glutathione metabolism
Arachidonic acid metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Chemical carcinogenesis - DNA adducts 		  Glutathione conjugation
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 25358668, 22874804, 22959778, 19528963
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Testicular Germ Cell Tumor Testicular Germ Cell Tumor GWAS
Show/Hide Text Mining Associations (25)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33050938, 36564744
Arthritis Rheumatoid Associate 10364914
Asthma Associate 23506843, 37231900
Breast Neoplasms Associate 23244102
Calcinosis Cutis Associate 18162130
Carcinoma Non Small Cell Lung Associate 26722539
Chronic Disease Associate 22108414
Chronic Periodontitis Associate 36833382
Diabetes Gestational Associate 26823865
Disease Progression Stimulate 27423494