Gene Gene information from NCBI Gene database.
Entrez ID 27297
Gene name CGRP receptor component
Gene symbol CRCP
Synonyms (NCBI Gene)
C17CGRP-RCPCGRPRCPPOLR3IPOLR3JRCPRCP9RPC9
Chromosome 7
Chromosome location 7q11.21
Summary This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided
miRNA miRNA information provided by mirtarbase database.
834
miRTarBase ID miRNA Experiments Reference
MIRT721241 hsa-miR-4432 HITS-CLIP 19536157
MIRT721240 hsa-miR-3145-5p HITS-CLIP 19536157
MIRT721239 hsa-miR-508-5p HITS-CLIP 19536157
MIRT721238 hsa-miR-451b HITS-CLIP 19536157
MIRT721237 hsa-miR-6501-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000428 Component DNA-directed RNA polymerase complex IEA
GO:0001635 Function Calcitonin gene-related peptide receptor activity IEA
GO:0001669 Component Acrosomal vesicle IEA
GO:0002376 Process Immune system process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606121 17888 ENSG00000241258
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75575
Protein name DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)
Protein function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III)
PDB 7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03874 RNA_pol_Rpb4 10 124 RNA polymerase Rpb4 Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Most prevalent in testis. {ECO:0000269|PubMed:10067875}.
Sequence
Sequence length 148
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  RNA polymerase   Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DIABETIC NEPHROPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Cubitus Valgus with Mental Retardation and Unusual Facies Associate 7253002
★☆☆☆☆
Found in Text Mining only
Growth Disorders Associate 2585460
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Associate 2585460
★☆☆☆☆
Found in Text Mining only