Gene Gene information from NCBI Gene database.
Entrez ID 27284
Gene name Sulfotransferase family 1B member 1
Gene symbol SULT1B1
Synonyms (NCBI Gene)
ST1B1ST1B2SULT1B2
Chromosome 4
Chromosome location 4q13.3
Summary Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and
miRNA miRNA information provided by mirtarbase database.
398
miRTarBase ID miRNA Experiments Reference
MIRT022947 hsa-miR-124-3p Microarray 18668037
MIRT029950 hsa-miR-26b-5p Microarray 19088304
MIRT509819 hsa-miR-410-3p HITS-CLIP 21572407
MIRT517943 hsa-miR-5580-3p HITS-CLIP 21572407
MIRT509818 hsa-miR-5011-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0004062 Function Aryl sulfotransferase activity IBA
GO:0004062 Function Aryl sulfotransferase activity IDA 9443824, 23207770
GO:0004062 Function Aryl sulfotransferase activity IEA
GO:0005515 Function Protein binding IPI 21044950, 25416956, 25910212, 32296183, 32814053
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608436 17845 ENSG00000173597
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43704
Protein name Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
Protein function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, tri
PDB 2Z5F , 3CKL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00685 Sulfotransfer_1 38 289 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. {ECO:0000269|PubMed:9463486}.
Sequence
Sequence length 296
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cytosolic sulfonation of small molecules
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Levothyroxine response other rs11249460 RCV003317016
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 28634336
Carcinoma Renal Cell Associate 31655797
Crohn Disease Inhibit 35872023
Neoplasms Associate 28634336