TINAG (tubulointerstitial nephritis antigen)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27283
Gene name Gene Name - the full gene name approved by the HGNC.
Tubulointerstitial nephritis antigen
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TINAG
Synonyms (NCBI Gene) Gene synonyms aliases
TIN-AG
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman`s capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubuloint
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT2349249 hsa-miR-1252 CLIP-seq
MIRT2349250 hsa-miR-4517 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding TAS 10652240
GO:0004197 Function Cysteine-type endopeptidase activity TAS 10652240
GO:0005604 Component Basement membrane IDA 1762287
GO:0005615 Component Extracellular space IBA 21873635
GO:0005764 Component Lysosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
606749 14599 ENSG00000137251
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q9UJW2
Protein name Tubulointerstitial nephritis antigen (TIN-Ag)
Protein function Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01033 Somatomedin_B 61 → 105 Somatomedin B domain Family
PF00112 Peptidase_C1 227 → 467 Papain family cysteine protease Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the kidney cortex, small intestine and cornea. {ECO:0000269|PubMed:10652240, ECO:0000269|PubMed:10752525, ECO:0000269|PubMed:1762287}.
Sequence 
MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
Sequence length 476
Interactions View interactions