Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27253
Gene name Gene Name - the full gene name approved by the HGNC.	Protocadherin 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCDH17
Synonyms (NCBI Gene) Gene synonyms aliases	PCDH68, PCH68
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q21.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. T

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miRTarBase ID	miRNA	Experiments	Reference
MIRT709689	hsa-miR-548m	HITS-CLIP	19536157
MIRT709688	hsa-miR-548ag	HITS-CLIP	19536157
MIRT709687	hsa-miR-548ai	HITS-CLIP	19536157
MIRT709686	hsa-miR-548ba	HITS-CLIP	19536157
MIRT709685	hsa-miR-570-5p	HITS-CLIP	19536157
MIRT709684	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT709683	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT709682	hsa-miR-6072	HITS-CLIP	19536157
MIRT709681	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709680	hsa-miR-5193	HITS-CLIP	19536157
MIRT709679	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT709678	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT709677	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709676	hsa-miR-4279	HITS-CLIP	19536157
MIRT709675	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709674	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT622911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622909	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622908	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622907	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622906	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT622905	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT709689	hsa-miR-548m	HITS-CLIP	19536157
MIRT709688	hsa-miR-548ag	HITS-CLIP	19536157
MIRT709687	hsa-miR-548ai	HITS-CLIP	19536157
MIRT709686	hsa-miR-548ba	HITS-CLIP	19536157
MIRT709685	hsa-miR-570-5p	HITS-CLIP	19536157
MIRT709684	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT709683	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT709682	hsa-miR-6072	HITS-CLIP	19536157
MIRT709681	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709680	hsa-miR-5193	HITS-CLIP	19536157
MIRT709679	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT709678	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT709677	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709676	hsa-miR-4279	HITS-CLIP	19536157
MIRT709675	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709674	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT622911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622909	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622908	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622907	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622906	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT622905	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT1216791	hsa-miR-1200	CLIP-seq
MIRT1216792	hsa-miR-127-5p	CLIP-seq
MIRT1216793	hsa-miR-224	CLIP-seq
MIRT1216794	hsa-miR-30a	CLIP-seq
MIRT1216795	hsa-miR-30b	CLIP-seq
MIRT1216796	hsa-miR-30c	CLIP-seq
MIRT1216797	hsa-miR-30d	CLIP-seq
MIRT1216798	hsa-miR-30e	CLIP-seq
MIRT1216799	hsa-miR-3140-5p	CLIP-seq
MIRT1216800	hsa-miR-3607-3p	CLIP-seq
MIRT1216801	hsa-miR-3662	CLIP-seq
MIRT1216802	hsa-miR-4282	CLIP-seq
MIRT1216803	hsa-miR-4310	CLIP-seq
MIRT1216804	hsa-miR-4446-5p	CLIP-seq
MIRT1216805	hsa-miR-4729	CLIP-seq
MIRT1216806	hsa-miR-4760-5p	CLIP-seq
MIRT1216807	hsa-miR-579	CLIP-seq
MIRT1216808	hsa-miR-590-3p	CLIP-seq
MIRT1921689	hsa-miR-4422	CLIP-seq
MIRT1216791	hsa-miR-1200	CLIP-seq
MIRT1216799	hsa-miR-3140-5p	CLIP-seq
MIRT2062563	hsa-miR-409-3p	CLIP-seq
MIRT1216804	hsa-miR-4446-5p	CLIP-seq
MIRT2291007	hsa-miR-140-3p	CLIP-seq
MIRT2291008	hsa-miR-217	CLIP-seq
MIRT2291009	hsa-miR-2276	CLIP-seq
MIRT2291010	hsa-miR-4789-5p	CLIP-seq
MIRT2588632	hsa-miR-1179	CLIP-seq
MIRT2588633	hsa-miR-3163	CLIP-seq
MIRT2588634	hsa-miR-340	CLIP-seq
MIRT2588635	hsa-miR-3653	CLIP-seq
MIRT2588636	hsa-miR-3658	CLIP-seq
MIRT2588637	hsa-miR-532-5p	CLIP-seq
MIRT2588632	hsa-miR-1179	CLIP-seq
MIRT2588633	hsa-miR-3163	CLIP-seq
MIRT2588634	hsa-miR-340	CLIP-seq
MIRT2588635	hsa-miR-3653	CLIP-seq
MIRT2588636	hsa-miR-3658	CLIP-seq
MIRT2588637	hsa-miR-532-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19945174, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0016020	Component	Membrane	IEA
GO:0030534	Process	Adult behavior	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050805	Process	Negative regulation of synaptic transmission	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1904071	Process	Presynaptic active zone assembly	IBA
GO:1904071	Process	Presynaptic active zone assembly	IEA
GO:2000807	Process	Regulation of synaptic vesicle clustering	IEA

MIM	HGNC	e!Ensembl
611760	14267	ENSG00000118946

Protein

UniProt ID

O14917

Protein name

Protocadherin-17 (Protocadherin-68)

Protein function

Potential calcium-dependent cell-adhesion protein.

PDB

6VFT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	20 → 112	Cadherin-like	Domain
PF00028	Cadherin	137 → 234	Cadherin domain	Domain
PF00028	Cadherin	248 → 342	Cadherin domain	Domain
PF00028	Cadherin	357 → 463	Cadherin domain	Domain
PF00028	Cadherin	477 → 574	Cadherin domain	Domain
PF00028	Cadherin	593 → 682	Cadherin domain	Domain

Sequence

MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSK
SGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKV
EIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFG
LDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNS
PVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKT
GLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA
LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDN
FYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQ
VHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSF
NFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRN
AGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVE
LVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILL
AAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAM
NVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQG
TNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADS
DQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPA
ANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLK
AKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLS
PSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVR
EIDKLLQDCRGNDPVAVRK

Sequence length

1159

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Associate	29575536
Breast Neoplasms	Inhibit	33896826
Carcinogenesis	Associate	24376576, 29575536
Carcinoma Hepatocellular	Associate	38145746
Carcinoma Non Small Cell Lung	Associate	33859751
Carcinoma Ovarian Epithelial	Associate	36698136
Carcinoma Renal Cell	Associate	21847011, 26404644, 28688232, 35838992
Carcinoma Transitional Cell	Associate	24567353
Colonic Neoplasms	Associate	29575536
Colorectal Neoplasms	Associate	29575536
Glomerulonephritis IGA	Associate	33319642
Hypoxia	Associate	33896826
Leukemia	Associate	30922328
Leukemia Myeloid Acute	Associate	30922328
Lung Neoplasms	Associate	29270240, 33859751
Lymphatic Metastasis	Associate	25091018, 26404644, 28688232
Microsatellite Instability	Associate	29575536
Neoplasm Invasiveness	Associate	25091018
Neoplasms	Associate	24567353, 25091018, 29575536, 29991130
Neoplasms	Inhibit	26404644, 28688232, 33896826, 36698136
Ovarian Diseases	Associate	36698136
Ovarian Neoplasms	Associate	29991130, 36698136
Prostatic Neoplasms	Associate	21847011, 25091018
Squamous Cell Carcinoma of Head and Neck	Associate	30454973
Stomach Neoplasms	Associate	24376576
Urinary Bladder Neoplasms	Associate	21847011, 24366498, 24567353, 26700620, 35241014
Urologic Neoplasms	Associate	21847011, 28688232

PCDH17 (protocadherin 17)