Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27246
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 115
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF115
Synonyms (NCBI Gene) Gene synonyms aliases
BCA2, RABRING7, ZFP364, ZNF364
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051949 hsa-let-7b-5p CLASH 23622248
MIRT041801 hsa-miR-484 CLASH 23622248
MIRT041372 hsa-miR-193b-3p CLASH 23622248
MIRT717495 hsa-miR-6841-5p HITS-CLIP 19536157
MIRT717494 hsa-miR-6755-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0004842 Function Ubiquitin-protein transferase activity IDA 18819927
GO:0005515 Function Protein binding IPI 16925951, 19690564, 21516116, 25416956, 31515488, 32296183, 32814053, 35044719
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619535 18154 ENSG00000265491
Protein
UniProt ID Q9Y4L5
Protein name E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
Protein function E3 ubiquitin-protein ligase that catalyzes the 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13639 zf-RING_2 226 269 Ring finger domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. {ECO:0000269|PubMed:16288031}.
Sequence
MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGG
SRIDNTTTTHFAELWGHLDHTMFFQDFRPFLSSSPLDQDNRANERGHQTHTDFWGARPPR
LPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAW
GQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEE
VRQLPCNHFFHSSCIVPWLELHDTCPVCR
KSLNGEDSTRQSQSTEASASNRFSNDSQLHD
RWTF
Sequence length 304
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Antigen processing: Ubiquitination & Proteasome degradation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast cancer Breast cancer N/A N/A GWAS
Gout Gout N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Moyamoya Disease Moyamoya disease N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Oxyphilic Associate 23242606
Breast Neoplasms Stimulate 18819927
Breast Neoplasms Associate 20222671, 22315970, 24027428, 24403860, 30689267
Burkitt Lymphoma Associate 19759907
Cardiomyopathy infantile histiocytoid Stimulate 23242606
Cerebellar Ataxia and Hypogonadotropic Hypogonadism Associate 22315970
Neoplasm Metastasis Associate 18819927
Neoplasms Associate 22315970
Oncocytoma renal Associate 23242606
Sleep Apnea Obstructive Associate 35132330