Gene Gene information from NCBI Gene database.
Entrez ID 27242
Gene name TNF receptor superfamily member 21
Gene symbol TNFRSF21
Synonyms (NCBI Gene)
BM-018CD358DR6
Chromosome 6
Chromosome location 6p12.3
Summary This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its deat
miRNA miRNA information provided by mirtarbase database.
466
miRTarBase ID miRNA Experiments Reference
MIRT002620 hsa-miR-124-3p Microarray 15685193
MIRT016429 hsa-miR-193b-3p Microarray 20304954
MIRT020190 hsa-miR-130b-3p Sequencing 20371350
MIRT002620 hsa-miR-124-3p Microarray 18668037
MIRT002620 hsa-miR-124-3p Microarray 15685193
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
VDR Activation 12520529
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0001783 Process B cell apoptotic process IEA
GO:0001783 Process B cell apoptotic process ISS
GO:0002250 Process Adaptive immune response IBA
GO:0002250 Process Adaptive immune response IEA
GO:0002250 Process Adaptive immune response ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605732 13469 ENSG00000146072
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75509
Protein name Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Protein function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers th
PDB 2DBH , 3QO4 , 3U3P , 3U3Q , 3U3S , 3U3T , 3U3V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00020 TNFR_c6 51 88 TNFR/NGFR cysteine-rich region Domain
PF00020 TNFR_c6 91 131 TNFR/NGFR cysteine-rich region Domain
PF00020 TNFR_c6 171 211 TNFR/NGFR cysteine-rich region Domain
PF00531 Death 417 498 Death domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lowe
Sequence
MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRA
TGQVLTCDKCPAGTYVSEHCTNTSLRVC
SSCPVGTFTRHENGIEKCHDCSQPCPWPMIEK
LPCAALTDREC
TCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVP
SSVMKCKAYTDCLSQNLVVIKPGTKETDNVC
GTLPSFSSSTSPSPGTAIFPRPEHMETHE
VPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNH
QQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLL
VLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILK
LVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLIS
ALRQHRRNDVVEKIRGLM
EDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEP
SPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIF
DDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
Sequence length 655
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction   PPARA activates gene expression