Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27185
Gene name Gene Name - the full gene name approved by the HGNC.	DISC1 scaffold protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DISC1
Synonyms (NCBI Gene) Gene synonyms aliases	C1orf136, SCZD9
Disease Acronyms (UniProt) Disease acronyms from UniProt database	SCZD9
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q42.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disru

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023117	hsa-miR-124-3p	Microarray	18668037
MIRT643487	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT643486	hsa-miR-622	HITS-CLIP	23824327
MIRT643485	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT643484	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT643483	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT643482	hsa-miR-4291	HITS-CLIP	23824327
MIRT452954	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT452953	hsa-miR-7851-3p	PAR-CLIP	23592263
MIRT452952	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT452951	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT452950	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT452949	hsa-miR-5186	PAR-CLIP	23592263
MIRT452948	hsa-miR-4537	PAR-CLIP	23592263
MIRT452947	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT452946	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT452945	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT452944	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT452943	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT452942	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT452941	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT452940	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT452939	hsa-miR-4458	PAR-CLIP	23592263
MIRT452938	hsa-miR-4500	PAR-CLIP	23592263
MIRT452937	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT452936	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT452935	hsa-miR-6086	PAR-CLIP	23592263
MIRT452934	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT452933	hsa-miR-4706	PAR-CLIP	23592263
MIRT452932	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT452931	hsa-miR-744-5p	PAR-CLIP	23592263
MIRT452930	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT452929	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT452928	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT452927	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT452926	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT452925	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT452924	hsa-miR-4451	PAR-CLIP	23592263
MIRT452923	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT452922	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT452921	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT452920	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT452919	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT452918	hsa-miR-3689c	PAR-CLIP	23592263
MIRT452917	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT452916	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT452915	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT452947	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT452947	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT452946	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT452946	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT452945	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT452945	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT452944	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT452944	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT452943	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT452943	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT452942	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT452942	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT452941	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT452941	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT452940	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT452940	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT452922	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT452922	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT452929	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT452929	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT452921	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT452921	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT452950	hsa-miR-3192-5p	PAR-CLIP	26701625
MIRT452950	hsa-miR-3192-5p	PAR-CLIP	26701625
MIRT452920	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT452920	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT452919	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT452919	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT452918	hsa-miR-3689c	PAR-CLIP	26701625
MIRT452918	hsa-miR-3689c	PAR-CLIP	26701625
MIRT452936	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT452936	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT452952	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT452952	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT452924	hsa-miR-4451	PAR-CLIP	26701625
MIRT452924	hsa-miR-4451	PAR-CLIP	26701625
MIRT452939	hsa-miR-4458	PAR-CLIP	26701625
MIRT452939	hsa-miR-4458	PAR-CLIP	26701625
MIRT452938	hsa-miR-4500	PAR-CLIP	26701625
MIRT452938	hsa-miR-4500	PAR-CLIP	26701625
MIRT452948	hsa-miR-4537	PAR-CLIP	26701625
MIRT452948	hsa-miR-4537	PAR-CLIP	26701625
MIRT452923	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT452923	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT452928	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT452928	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT452954	hsa-miR-490-3p	PAR-CLIP	26701625
MIRT452954	hsa-miR-490-3p	PAR-CLIP	26701625
MIRT452949	hsa-miR-5186	PAR-CLIP	26701625
MIRT452949	hsa-miR-5186	PAR-CLIP	26701625
MIRT452935	hsa-miR-6086	PAR-CLIP	26701625
MIRT452935	hsa-miR-6086	PAR-CLIP	26701625
MIRT452934	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT452934	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT452915	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT452915	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT452917	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT452917	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT452916	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT452916	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT452927	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT452927	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT452925	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT452925	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT452951	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT452951	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT452926	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT452926	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT452930	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT452930	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT452953	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT452953	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT452937	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT452937	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT452947	hsa-let-7a-5p	PAR-CLIP	27292025
MIRT452946	hsa-let-7b-5p	PAR-CLIP	27292025
MIRT452945	hsa-let-7c-5p	PAR-CLIP	27292025
MIRT452944	hsa-let-7d-5p	PAR-CLIP	27292025
MIRT452943	hsa-let-7e-5p	PAR-CLIP	27292025
MIRT452942	hsa-let-7f-5p	PAR-CLIP	27292025
MIRT452941	hsa-let-7g-5p	PAR-CLIP	27292025
MIRT452940	hsa-let-7i-5p	PAR-CLIP	27292025
MIRT452922	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT452929	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT452921	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT452950	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT452920	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT452919	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT452918	hsa-miR-3689c	PAR-CLIP	27292025
MIRT452936	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT452952	hsa-miR-3927-3p	PAR-CLIP	27292025
MIRT452924	hsa-miR-4451	PAR-CLIP	27292025
MIRT452939	hsa-miR-4458	PAR-CLIP	27292025
MIRT452938	hsa-miR-4500	PAR-CLIP	27292025
MIRT452948	hsa-miR-4537	PAR-CLIP	27292025
MIRT452923	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT452928	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT452954	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT452949	hsa-miR-5186	PAR-CLIP	27292025
MIRT452935	hsa-miR-6086	PAR-CLIP	27292025
MIRT452934	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT452915	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT452917	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT452916	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT452927	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT452925	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT452951	hsa-miR-6831-5p	PAR-CLIP	27292025
MIRT452926	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT452930	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT452953	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT452937	hsa-miR-98-5p	PAR-CLIP	27292025
MIRT643487	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT643486	hsa-miR-622	HITS-CLIP	23824327
MIRT643485	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT643484	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT643483	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT643482	hsa-miR-4291	HITS-CLIP	23824327
MIRT452954	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT452953	hsa-miR-7851-3p	PAR-CLIP	23592263
MIRT452952	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT452951	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT452950	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT452949	hsa-miR-5186	PAR-CLIP	23592263
MIRT452948	hsa-miR-4537	PAR-CLIP	23592263
MIRT452947	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT452946	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT452945	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT452944	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT452943	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT452942	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT452941	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT452940	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT452939	hsa-miR-4458	PAR-CLIP	23592263
MIRT452938	hsa-miR-4500	PAR-CLIP	23592263
MIRT452937	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT452936	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT452935	hsa-miR-6086	PAR-CLIP	23592263
MIRT452934	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT452933	hsa-miR-4706	PAR-CLIP	23592263
MIRT452932	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT452931	hsa-miR-744-5p	PAR-CLIP	23592263
MIRT452930	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT452929	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT452928	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT452927	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT452926	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT452925	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT452924	hsa-miR-4451	PAR-CLIP	23592263
MIRT452923	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT452922	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT452921	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT452920	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT452919	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT452918	hsa-miR-3689c	PAR-CLIP	23592263
MIRT452917	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT452916	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT452915	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT937222	hsa-miR-1285	CLIP-seq
MIRT937223	hsa-miR-192	CLIP-seq
MIRT937224	hsa-miR-198	CLIP-seq
MIRT937225	hsa-miR-215	CLIP-seq
MIRT937226	hsa-miR-3187-5p	CLIP-seq
MIRT937227	hsa-miR-4645-3p	CLIP-seq
MIRT937228	hsa-miR-612	CLIP-seq
MIRT937229	hsa-miR-101	CLIP-seq
MIRT937230	hsa-miR-106a	CLIP-seq
MIRT937231	hsa-miR-106b	CLIP-seq
MIRT937232	hsa-miR-17	CLIP-seq
MIRT937233	hsa-miR-20a	CLIP-seq
MIRT937234	hsa-miR-20b	CLIP-seq
MIRT937235	hsa-miR-3609	CLIP-seq
MIRT937236	hsa-miR-4796-3p	CLIP-seq
MIRT937237	hsa-miR-519d	CLIP-seq
MIRT937238	hsa-miR-548ah	CLIP-seq
MIRT937239	hsa-miR-93	CLIP-seq
MIRT937240	hsa-miR-1254	CLIP-seq
MIRT937241	hsa-miR-1256	CLIP-seq
MIRT937242	hsa-miR-1278	CLIP-seq
MIRT937243	hsa-miR-1343	CLIP-seq
MIRT937244	hsa-miR-140-5p	CLIP-seq
MIRT937245	hsa-miR-146b-3p	CLIP-seq
MIRT937246	hsa-miR-1827	CLIP-seq
MIRT937247	hsa-miR-1908	CLIP-seq
MIRT937248	hsa-miR-1911	CLIP-seq
MIRT937249	hsa-miR-1914	CLIP-seq
MIRT937250	hsa-miR-2110	CLIP-seq
MIRT937251	hsa-miR-217	CLIP-seq
MIRT937252	hsa-miR-3074-5p	CLIP-seq
MIRT937253	hsa-miR-3116	CLIP-seq
MIRT937254	hsa-miR-3152-3p	CLIP-seq
MIRT937255	hsa-miR-3155	CLIP-seq
MIRT937256	hsa-miR-3155b	CLIP-seq
MIRT937257	hsa-miR-3190	CLIP-seq
MIRT937258	hsa-miR-331-3p	CLIP-seq
MIRT937259	hsa-miR-339-5p	CLIP-seq
MIRT937260	hsa-miR-3617	CLIP-seq
MIRT937261	hsa-miR-371-5p	CLIP-seq
MIRT937262	hsa-miR-371b-5p	CLIP-seq
MIRT937263	hsa-miR-3929	CLIP-seq
MIRT937264	hsa-miR-4271	CLIP-seq
MIRT937265	hsa-miR-4418	CLIP-seq
MIRT937266	hsa-miR-4419b	CLIP-seq
MIRT937267	hsa-miR-4421	CLIP-seq
MIRT937268	hsa-miR-4478	CLIP-seq
MIRT937269	hsa-miR-4481	CLIP-seq
MIRT937270	hsa-miR-4649-3p	CLIP-seq
MIRT937271	hsa-miR-4658	CLIP-seq
MIRT937272	hsa-miR-4667-5p	CLIP-seq
MIRT937273	hsa-miR-4677-3p	CLIP-seq
MIRT937274	hsa-miR-4684-5p	CLIP-seq
MIRT937275	hsa-miR-4700-5p	CLIP-seq
MIRT937276	hsa-miR-4720-5p	CLIP-seq
MIRT937277	hsa-miR-4723-5p	CLIP-seq
MIRT937278	hsa-miR-4725-3p	CLIP-seq
MIRT937279	hsa-miR-4745-5p	CLIP-seq
MIRT937280	hsa-miR-4758-5p	CLIP-seq
MIRT937281	hsa-miR-4762-5p	CLIP-seq
MIRT937282	hsa-miR-4765	CLIP-seq
MIRT937283	hsa-miR-4766-5p	CLIP-seq
MIRT937284	hsa-miR-4786-3p	CLIP-seq
MIRT937285	hsa-miR-4789-5p	CLIP-seq
MIRT937286	hsa-miR-4793-3p	CLIP-seq
MIRT937287	hsa-miR-4799-3p	CLIP-seq
MIRT937288	hsa-miR-484	CLIP-seq
MIRT937289	hsa-miR-485-5p	CLIP-seq
MIRT937290	hsa-miR-494	CLIP-seq
MIRT937291	hsa-miR-509-3-5p	CLIP-seq
MIRT937292	hsa-miR-509-5p	CLIP-seq
MIRT937293	hsa-miR-548c-3p	CLIP-seq
MIRT937294	hsa-miR-552	CLIP-seq
MIRT937295	hsa-miR-593	CLIP-seq
MIRT937296	hsa-miR-641	CLIP-seq
MIRT937297	hsa-miR-652	CLIP-seq
MIRT937298	hsa-miR-661	CLIP-seq
MIRT937299	hsa-miR-663	CLIP-seq
MIRT937300	hsa-miR-7	CLIP-seq
MIRT937301	hsa-miR-890	CLIP-seq
MIRT937302	hsa-miR-892a	CLIP-seq
MIRT937240	hsa-miR-1254	CLIP-seq
MIRT937253	hsa-miR-3116	CLIP-seq
MIRT937303	hsa-miR-4701-5p	CLIP-seq
MIRT937304	hsa-miR-4727-5p	CLIP-seq
MIRT937305	hsa-miR-543	CLIP-seq
MIRT937306	hsa-miR-588	CLIP-seq
MIRT937298	hsa-miR-661	CLIP-seq
MIRT937307	hsa-miR-1224-3p	CLIP-seq
MIRT937308	hsa-miR-1299	CLIP-seq
MIRT937309	hsa-miR-4286	CLIP-seq
MIRT937300	hsa-miR-7	CLIP-seq
MIRT937310	hsa-miR-875-3p	CLIP-seq
MIRT2212768	hsa-miR-2964a-5p	CLIP-seq
MIRT2212769	hsa-miR-433	CLIP-seq
MIRT2212770	hsa-miR-4509	CLIP-seq
MIRT2212771	hsa-miR-4725-5p	CLIP-seq
MIRT2212772	hsa-miR-4744	CLIP-seq
MIRT2212773	hsa-miR-4780	CLIP-seq
MIRT2212774	hsa-miR-504	CLIP-seq
MIRT2212775	hsa-miR-563	CLIP-seq
MIRT2212776	hsa-miR-584	CLIP-seq
MIRT2212777	hsa-miR-602	CLIP-seq
MIRT2448275	hsa-miR-1252	CLIP-seq
MIRT2448276	hsa-miR-214	CLIP-seq
MIRT2448277	hsa-miR-3154	CLIP-seq
MIRT2448278	hsa-miR-3619-5p	CLIP-seq
MIRT2448279	hsa-miR-4293	CLIP-seq
MIRT2448280	hsa-miR-4530	CLIP-seq
MIRT2448281	hsa-miR-4690-3p	CLIP-seq
MIRT2448282	hsa-miR-4722-5p	CLIP-seq
MIRT2448283	hsa-miR-545	CLIP-seq
MIRT2448284	hsa-miR-761	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ATF4	Unknown	12812986
ATF5	Unknown	12812986

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IMP	18955030
GO:0001764	Process	Neuron migration	IBA	21873635
GO:0001764	Process	Neuron migration	IMP	19502360
GO:0001954	Process	Positive regulation of cell-matrix adhesion	IEA
GO:0002052	Process	Positive regulation of neuroblast proliferation	IGI	19303846
GO:0005515	Function	Protein binding	IPI	12812986, 15094396, 17035248, 17043677, 17389905, 18762586, 18955030, 20956536, 22153077, 22228767, 31413325
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	20880836
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005813	Component	Centrosome	IBA	21873635
GO:0005813	Component	Centrosome	IDA	18762586, 18955030, 20531939
GO:0005829	Component	Cytosol	IEA
GO:0005871	Component	Kinesin complex	IEA
GO:0005874	Component	Microtubule	IBA	21873635
GO:0008021	Component	Synaptic vesicle	IEA
GO:0010975	Process	Regulation of neuron projection development	IBA	21873635
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0019894	Function	Kinesin binding	IEA
GO:0021846	Process	Cell proliferation in forebrain	IEA
GO:0021852	Process	Pyramidal neuron migration	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IGI	19303846
GO:0030286	Component	Dynein complex	IEA
GO:0031929	Process	TOR signaling	IEA
GO:0032091	Process	Negative regulation of protein binding	ISS
GO:0036064	Component	Ciliary basal body	IEA
GO:0044297	Component	Cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045111	Component	Intermediate filament cytoskeleton	IBA	21873635
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0051602	Process	Response to electrical stimulus	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060090	Function	Molecular adaptor activity	IEA
GO:0060271	Process	Cilium assembly	IBA	21873635
GO:0060998	Process	Regulation of dendritic spine development	IEA
GO:0071539	Process	Protein localization to centrosome	IEA
GO:0090128	Process	Regulation of synapse maturation	IEA
GO:0090724	Component	Central region of growth cone	IEA
GO:0097546	Component	Ciliary base	IDA	20531939
GO:1905515	Process	Non-motile cilium assembly	IMP	20531939
GO:2000060	Process	Positive regulation of ubiquitin-dependent protein catabolic process	IEA

MIM	HGNC	e!Ensembl
605210	2888	ENSG00000162946

Protein

UniProt ID

Q9NRI5

Protein name

Disrupted in schizophrenia 1 protein

Protein function

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the

PDB

5V4B

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. {ECO:0000269|PubMed:16510495}.

Sequence

MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER
QMDDLEGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGE
KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREA
AASCMTAGVHEAQA

Sequence length

854

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Agenesis of corpus callosum	Agenesis of corpus callosum	rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	17579608, 20002455
Mental retardation	Profound Mental Retardation, Mental deficiency, Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)	20002455
Polymicrogyria	Polymicrogyria	rs1558010146, rs1558003446, rs1575508937
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	20531374, 20561508

Show/Hide Unknown Diseases (4)

Disease term	Disease name	References	Source
Unknown
Mental depression	Mental Depression, Endogenous depression, Depressive disorder, Unipolar Depression, Depressive Syndrome, Depression, Neurotic, Major Depressive Disorder	25533973, 23602339, 22547224, 23011268, 22348257, 29643356, 25272038, 24934694, 25705664, 25043320, 25487992	ClinVar
Metabolic Syndrome	Metabolic Syndrome		GWAS
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis		GWAS
Mental Depression	Mental Depression		GWAS

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	32345670
Alzheimer Disease	Inhibit	34981809
Anhedonia	Associate	24934694
Anxiety	Associate	25533973
Anxiety Disorders	Associate	25533973
Asperger Syndrome	Associate	19251251, 21569632
Autism Spectrum Disorder	Associate	19606485
Autistic Disorder	Associate	19251251, 21569632
Bipolar Disorder	Associate	15386212, 19251251, 19300510, 19448849, 21091867, 21483430, 23032945, 25620115, 26301809, 28630456
Carcinoma Hepatocellular	Associate	35833210
Chronic Periodontitis	Associate	27601451
Cognition Disorders	Associate	27629381, 28630456
Colorectal Neoplasms	Associate	32345670
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	22952026, 28630456
Craniometaphyseal Dysplasia Autosomal Dominant	Associate	22952026
Depressive Disorder	Associate	19300510, 21483430, 25533973, 31106784
Depressive Disorder Major	Associate	19251251, 19448849, 21483430, 23732877, 24934694, 28630456
Disease	Associate	21853134, 29643329
Epilepsy Tonic Clonic	Associate	19805229
Gaucher Disease	Associate	33568133
Graves Disease	Associate	33568133, 36397361
Hepatitis D	Associate	26101851
Hippocampal Sclerosis	Associate	19046394
Hyperlipidemias	Associate	22369086
Intellectual Disability	Associate	22952026, 28630456
Major Affective Disorder 2	Associate	11443544
Malformations of Cortical Development Group II	Associate	18762586
Mental Disorders	Associate	10814723, 15386212, 15657124, 18762586, 19251251, 19300510, 19606485, 19805229, 21483430, 21569632, 21853134, 21998303, 22363459, 22832604, 24146131 View all (12 more)
Mitochondrial Diseases	Inhibit	20880836
Mood Disorders	Associate	25533973
Myocardial Infarction	Associate	22369086
Neoplasms	Associate	32345670, 35833210
Neurodegenerative Diseases	Associate	22952026
Neurotoxicity Syndromes	Associate	34831151
Opioid Related Disorders	Associate	26997180
Panic Disorder	Associate	21483430
Psychotic Disorders	Associate	15386212, 15657124, 18762586, 19300510, 21483430, 21878470, 22363459, 24474471, 26101851, 29945223, 37668563
Schizophrenia	Associate	10814723, 11443544, 15386212, 15657124, 18762586, 19046394, 19251251, 19300510, 19448849, 19805229, 20880836, 21091867, 21483430, 21853134, 21876540 View all (14 more)
Substance Related Disorders	Associate	15657124
Tomaculous neuropathy	Associate	37508512

DISC1 (DISC1 scaffold protein)