Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27173
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 39 member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC39A1
Synonyms (NCBI Gene) Gene synonyms aliases
ZIP1, ZIRTL
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer`s disease. Alternative spl
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024724 hsa-miR-215-5p Microarray 19074876
MIRT026105 hsa-miR-192-5p Microarray 19074876
MIRT027938 hsa-miR-96-5p Sequencing 20371350
MIRT047939 hsa-miR-30c-5p CLASH 23622248
MIRT037329 hsa-miR-877-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 19026724
SP1 Unknown 19026724
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0005102 Function Signaling receptor binding IEA
GO:0005385 Function Zinc ion transmembrane transporter activity IBA
GO:0005385 Function Zinc ion transmembrane transporter activity IDA 11301334
GO:0005385 Function Zinc ion transmembrane transporter activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604740 12876 ENSG00000143570
Protein
UniProt ID Q9NY26
Protein name Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)
Protein function Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into prostat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02535 Zip 27 320 ZIP Zinc transporter Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous (PubMed:10610721, PubMed:11301334). Expressed in most adult and fetal tissues including the epidermis. {ECO:0000269|PubMed:10610721, ECO:0000269|PubMed:11301334}.
Sequence
Sequence length 324
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Alzheimer disease
Parkinson disease
  Zinc influx into cells by the SLC39 gene family
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Mucinous Inhibit 26081940
Breast Neoplasms Stimulate 32744318
Carcinogenesis Associate 26081940
Carcinoma Hepatocellular Inhibit 34615436
Glioma Associate 37934565
Neoplasms Inhibit 16153295, 22045813
Neoplasms Cystic Mucinous and Serous Associate 26081940
Neoplasms Glandular and Epithelial Associate 16153295
Ovarian Neoplasms Inhibit 26081940
Prostatic Neoplasms Associate 16153295, 19802870, 21360563, 21940908