Gene Gene information from NCBI Gene database.
Entrez ID 27173
Gene name Solute carrier family 39 member 1
Gene symbol SLC39A1
Synonyms (NCBI Gene)
ZIP1ZIRTL
Chromosome 1
Chromosome location 1q21.3
Summary This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer`s disease. Alternative spl
miRNA miRNA information provided by mirtarbase database.
453
miRTarBase ID miRNA Experiments Reference
MIRT024724 hsa-miR-215-5p Microarray 19074876
MIRT026105 hsa-miR-192-5p Microarray 19074876
MIRT027938 hsa-miR-96-5p Sequencing 20371350
MIRT047939 hsa-miR-30c-5p CLASH 23622248
MIRT037329 hsa-miR-877-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
CREB1 Unknown 19026724
SP1 Unknown 19026724
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0005102 Function Signaling receptor binding IEA
GO:0005385 Function Zinc ion transmembrane transporter activity IBA
GO:0005385 Function Zinc ion transmembrane transporter activity IDA 11301334
GO:0005385 Function Zinc ion transmembrane transporter activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604740 12876 ENSG00000143570
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NY26
Protein name Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)
Protein function Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into prostat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02535 Zip 27 320 ZIP Zinc transporter Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous (PubMed:10610721, PubMed:11301334). Expressed in most adult and fetal tissues including the epidermis. {ECO:0000269|PubMed:10610721, ECO:0000269|PubMed:11301334}.
Sequence
Sequence length 324
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Alzheimer disease
Parkinson disease
  Zinc influx into cells by the SLC39 gene family