AGO2 (argonaute RISC catalytic component 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 27161
Gene name Argonaute RISC catalytic component 2
Gene symbol AGO2
Synonyms (NCBI Gene)
CASC7EIF2C2LESKRESLINC00980PPDQ10
Chromosome 8
Chromosome location 8q24.3
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-me
miRNA miRNA information provided by mirtarbase database.
2382
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (2382)
miRTarBase ID miRNA Experiments Reference
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT024741 hsa-miR-215-5p Microarray 19074876
MIRT026680 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
115
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (115)
GO ID Ontology Definition Evidence Reference
GO:0000340 Function RNA 7-methylguanosine cap binding IDA 17524464
GO:0000340 Function RNA 7-methylguanosine cap binding IEA
GO:0000932 Component P-body IDA 20616046, 22915799, 23125361
GO:0000932 Component P-body IEA
GO:0000993 Function RNA polymerase II complex binding IDA 25336585
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606229 3263 ENSG00000123908
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKV8
Protein name Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Protein function Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs dire
PDB 3LUC , 3LUD , 3LUG , 3LUH , 3LUJ , 3LUK , 3QX8 , 3QX9 , 4F3T , 4OLA , 4OLB , 4W5N , 4W5O , 4W5Q , 4W5R , 4W5T , 4Z4C , 4Z4D , 4Z4E , 4Z4F , 4Z4G , 4Z4H , 4Z4I , 5JS1 , 5JS2 , 5KI6 , 5T7B , 5WEA , 6CBD , 6MDZ , 6MFN , 6MFR , 6N4O , 6NIT , 6RA4 , 7C6B , 7D7U , 7KI3 , 8D6J , 8D71 , 8THQ , 9BEZ , 9BF0 , 9BF2 , 9CMP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16486 ArgoN 36 → 166 N-terminal domain of argonaute Domain
PF08699 ArgoL1 176 → 226 Argonaute linker 1 domain Domain
PF02170 PAZ 231 → 365 PAZ domain Domain
PF16488 ArgoL2 374 → 420 Argonaute linker 2 domain Family
PF16487 ArgoMid 429 → 511 Mid domain of argonaute Domain
PF02171 Piwi 517 → 818 Piwi domain Family
Sequence 
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
ALAKAVQVHQDTLRTMYFA
Sequence length 859
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
39
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lessel-Kreienkamp syndrome Likely pathogenic; Pathogenic rs2132941125, rs1564077207, rs2540704889, rs1467755029, rs2540729687, rs2073179658, rs2073092496, rs2073092234, rs2072680461, rs2073180302, rs2072681689 RCV001785279
RCV001795619
RCV002466934
RCV002795910
RCV003989087
RCV001289983
RCV001289984
RCV001289985
RCV001289986
RCV001289987
RCV001289988
Neurodevelopmental disorder Likely pathogenic; Pathogenic rs866981753 RCV002276887
Premature ovarian failure 3 Likely pathogenic rs2540671184 RCV003324100
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
AGO2-related disorder Benign; Uncertain significance rs2292781, rs2549626135, rs2540679800, rs2540672241, rs2540708804, rs1384149030, rs2292779 RCV003976228
RCV003405790
RCV003418750
RCV003408575
RCV003410471
RCV003977187
RCV003978161
Malignant tumor of esophagus Likely benign rs371401188 RCV005903052
Show/Hide Text Mining Associations (78)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 27463019
Arthritis Rheumatoid Associate 2972742
Asthma Associate 32512817
Bone Diseases Associate 36454786
Brain Injuries Traumatic Associate 37889026
Breast Neoplasms Associate 18787018, 19723326, 22639842, 23636329, 23696926, 24398324, 24574065, 29941603, 30622242, 30999843, 31324173, 36613808, 37353728
Breast Neoplasms Stimulate 31280346
Breast Neoplasms Male Associate 33964913
Burkitt Lymphoma Associate 29458013
Carcinogenesis Associate 23411422, 24427355, 26545861, 30621629