CHIA (chitinase acidic)

Gene

• Entrez ID: 27159
• Gene name: Chitinase acidic
• Gene symbol: CHIA
• Synonyms (NCBI Gene): AMCASE, CHIT2, TSA1902
• Chromosome: 1
• Chromosome location: 1p13.2
• Summary: The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma s

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000272	Process	Polysaccharide catabolic process	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002532	Process	Production of molecular mediator involved in inflammatory response	IDA	18824549
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004568	Function	Chitinase activity	IBA
GO:0004568	Function	Chitinase activity	IDA	19435888
GO:0004568	Function	Chitinase activity	IEA
GO:0004568	Function	Chitinase activity	NAS	10548734
GO:0004568	Function	Chitinase activity	TAS
GO:0005515	Function	Protein binding	IPI	18824549, 32296183
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	18824549
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005737	Component	Cytoplasm	NAS	10548734
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006030	Process	Chitin metabolic process	NAS	10548734
GO:0006032	Process	Chitin catabolic process	IBA
GO:0006032	Process	Chitin catabolic process	IDA	19435888
GO:0006032	Process	Chitin catabolic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0008061	Function	Chitin binding	IEA
GO:0008843	Function	Endochitinase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0019900	Function	Kinase binding	IPI	18824549
GO:0032722	Process	Positive regulation of chemokine production	IDA	18824549
GO:0044245	Process	Polysaccharide digestion	IEA
GO:0044245	Process	Polysaccharide digestion	TAS

Other IDs

• MIM: 606080
• HGNC: 17432
• e!Ensembl: ENSG00000134216

Protein

• UniProt ID: Q9BZP6
• Protein name: Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902)
• Protein function: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13.
• PDB: 2YBT, 2YBU, 3FXY, 3FY1, 3RM4, 3RM8, 3RM9, 3RME
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00704	Glyco_hydro_18	23 → 365	Glycosyl hydrolases family 18	Domain
  PF01607	CBM_14	430 → 476	Chitin binding Peritrophin-A domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:15192232}.
• Sequence:

  MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
  RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
  TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
  TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
  LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
  WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
  AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
  GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA

• Sequence length: 476

Pathways

KEGG:

Amino sugar and nucleotide sugar metabolism
Metabolic pathways

Reactome:

Digestion of dietary carbohydrate

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