Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27145
Gene name Gene Name - the full gene name approved by the HGNC.	Filamin A interacting protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FILIP1
Synonyms (NCBI Gene) Gene synonyms aliases	FILIP, NMDF
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q14.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine

Show/Hide all(40)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024001	hsa-miR-1-3p	Microarray	18668037
MIRT996894	hsa-miR-186	CLIP-seq
MIRT996895	hsa-miR-2054	CLIP-seq
MIRT996896	hsa-miR-3133	CLIP-seq
MIRT996897	hsa-miR-3180-5p	CLIP-seq
MIRT739795	hsa-miR-3190	CLIP-seq
MIRT739793	hsa-miR-323-3p	CLIP-seq
MIRT996898	hsa-miR-338-3p	CLIP-seq
MIRT996899	hsa-miR-4422	CLIP-seq
MIRT996900	hsa-miR-4495	CLIP-seq
MIRT996901	hsa-miR-4511	CLIP-seq
MIRT996902	hsa-miR-4530	CLIP-seq
MIRT996903	hsa-miR-4666-5p	CLIP-seq
MIRT996904	hsa-miR-4760-3p	CLIP-seq
MIRT739792	hsa-miR-513a-3p	CLIP-seq
MIRT996905	hsa-miR-548a-5p	CLIP-seq
MIRT996906	hsa-miR-548ab	CLIP-seq
MIRT996907	hsa-miR-548ak	CLIP-seq
MIRT996908	hsa-miR-548b-5p	CLIP-seq
MIRT996909	hsa-miR-548c-5p	CLIP-seq
MIRT996910	hsa-miR-548d-5p	CLIP-seq
MIRT996911	hsa-miR-548h	CLIP-seq
MIRT996912	hsa-miR-548i	CLIP-seq
MIRT996913	hsa-miR-548j	CLIP-seq
MIRT996914	hsa-miR-548k	CLIP-seq
MIRT996915	hsa-miR-548l	CLIP-seq
MIRT996916	hsa-miR-548w	CLIP-seq
MIRT996917	hsa-miR-548y	CLIP-seq
MIRT996918	hsa-miR-559	CLIP-seq
MIRT996919	hsa-miR-583	CLIP-seq
MIRT739794	hsa-miR-624	CLIP-seq
MIRT996920	hsa-miR-654-3p	CLIP-seq
MIRT996894	hsa-miR-186	CLIP-seq
MIRT996896	hsa-miR-3133	CLIP-seq
MIRT996900	hsa-miR-4495	CLIP-seq
MIRT996901	hsa-miR-4511	CLIP-seq
MIRT996903	hsa-miR-4666-5p	CLIP-seq
MIRT2533545	hsa-miR-340	CLIP-seq
MIRT2533546	hsa-miR-4259	CLIP-seq
MIRT2533547	hsa-miR-4715-5p	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence
GO:0001764	Process	Neuron migration	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0022038	Process	Corpus callosum development	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099010	Process	Modification of postsynaptic structure	IEA
GO:1903119	Process	Protein localization to actin cytoskeleton	IBA

MIM	HGNC	e!Ensembl
607307	21015	ENSG00000118407

Protein

UniProt ID

Q7Z7B0

Protein name

Filamin-A-interacting protein 1 (FILIP)

Protein function

By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09727	CortBP2	71 → 256	Cortactin-binding protein-2	Family

Tissue specificity

TISSUE SPECIFICITY: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is f

Sequence

MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK
TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP
EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV
YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL
VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE
VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ
ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE
LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL
ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV
MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL
DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY
DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL
KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK
RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQ
VGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEV
VLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNV
MPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE
IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG
TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR
GTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKS
AASSTTSLGGGKG

Sequence length

1213

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthrogryposis	Associate	36943452
Body Dysmorphic Disorders	Associate	37163662
Congenital Abnormalities	Associate	37163662
Genetic Diseases Inborn	Associate	36943452, 37163662
Microcephaly	Associate	36943452
Myotonia Congenita	Associate	37163662
Nervous System Malformations	Associate	37163662
Neurologic Manifestations	Associate	37163662

FILIP1 (filamin A interacting protein 1)