Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	27136
Gene name	MORC family CW-type zinc finger 1
Gene symbol	MORC1
Synonyms (NCBI Gene)	CT33MORCZCW6
Chromosome	3
Chromosome location	3q13.13
Summary	This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies furthe

Show/Hide all (63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT496067	hsa-miR-106a-5p	PAR-CLIP	22291592
MIRT496066	hsa-miR-106b-5p	PAR-CLIP	22291592
MIRT496065	hsa-miR-17-5p	PAR-CLIP	22291592
MIRT496064	hsa-miR-20a-5p	PAR-CLIP	22291592
MIRT496063	hsa-miR-20b-5p	PAR-CLIP	22291592
MIRT496062	hsa-miR-519d-3p	PAR-CLIP	22291592
MIRT496061	hsa-miR-526b-3p	PAR-CLIP	22291592
MIRT496060	hsa-miR-93-5p	PAR-CLIP	22291592
MIRT496059	hsa-miR-302a-3p	PAR-CLIP	22291592
MIRT496058	hsa-miR-302b-3p	PAR-CLIP	22291592
MIRT496057	hsa-miR-302c-3p	PAR-CLIP	22291592
MIRT496056	hsa-miR-302d-3p	PAR-CLIP	22291592
MIRT496055	hsa-miR-302e	PAR-CLIP	22291592
MIRT496054	hsa-miR-372-3p	PAR-CLIP	22291592
MIRT496053	hsa-miR-373-3p	PAR-CLIP	22291592
MIRT496052	hsa-miR-520a-3p	PAR-CLIP	22291592
MIRT496051	hsa-miR-520b	PAR-CLIP	22291592
MIRT496050	hsa-miR-520c-3p	PAR-CLIP	22291592
MIRT496049	hsa-miR-520d-3p	PAR-CLIP	22291592
MIRT496048	hsa-miR-520e	PAR-CLIP	22291592
MIRT496047	hsa-miR-3973	PAR-CLIP	22291592
MIRT496046	hsa-miR-520g-3p	PAR-CLIP	22291592
MIRT496045	hsa-miR-520h	PAR-CLIP	22291592
MIRT496044	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT496043	hsa-miR-607	PAR-CLIP	22291592
MIRT496042	hsa-miR-1305	PAR-CLIP	22291592
MIRT496041	hsa-miR-335-3p	PAR-CLIP	22291592
MIRT496067	hsa-miR-106a-5p	PAR-CLIP	22291592
MIRT496066	hsa-miR-106b-5p	PAR-CLIP	22291592
MIRT496065	hsa-miR-17-5p	PAR-CLIP	22291592
MIRT496064	hsa-miR-20a-5p	PAR-CLIP	22291592
MIRT496063	hsa-miR-20b-5p	PAR-CLIP	22291592
MIRT496062	hsa-miR-519d-3p	PAR-CLIP	22291592
MIRT496061	hsa-miR-526b-3p	PAR-CLIP	22291592
MIRT496060	hsa-miR-93-5p	PAR-CLIP	22291592
MIRT496059	hsa-miR-302a-3p	PAR-CLIP	22291592
MIRT496058	hsa-miR-302b-3p	PAR-CLIP	22291592
MIRT496057	hsa-miR-302c-3p	PAR-CLIP	22291592
MIRT496056	hsa-miR-302d-3p	PAR-CLIP	22291592
MIRT496055	hsa-miR-302e	PAR-CLIP	22291592
MIRT496054	hsa-miR-372-3p	PAR-CLIP	22291592
MIRT496053	hsa-miR-373-3p	PAR-CLIP	22291592
MIRT496052	hsa-miR-520a-3p	PAR-CLIP	22291592
MIRT496051	hsa-miR-520b	PAR-CLIP	22291592
MIRT496050	hsa-miR-520c-3p	PAR-CLIP	22291592
MIRT496049	hsa-miR-520d-3p	PAR-CLIP	22291592
MIRT496048	hsa-miR-520e	PAR-CLIP	22291592
MIRT496047	hsa-miR-3973	PAR-CLIP	22291592
MIRT496046	hsa-miR-520g-3p	PAR-CLIP	22291592
MIRT496045	hsa-miR-520h	PAR-CLIP	22291592
MIRT496044	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT496043	hsa-miR-607	PAR-CLIP	22291592
MIRT496042	hsa-miR-1305	PAR-CLIP	22291592
MIRT496041	hsa-miR-335-3p	PAR-CLIP	22291592
MIRT2273693	hsa-miR-136	CLIP-seq
MIRT2273694	hsa-miR-4731-3p	CLIP-seq
MIRT2273695	hsa-miR-4777-5p	CLIP-seq
MIRT2273696	hsa-miR-4801	CLIP-seq
MIRT2273697	hsa-miR-518d-5p	CLIP-seq
MIRT2273698	hsa-miR-519b-5p	CLIP-seq
MIRT2273699	hsa-miR-519c-5p	CLIP-seq
MIRT2273700	hsa-miR-520c-5p	CLIP-seq
MIRT2273701	hsa-miR-526a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001662	Process	Behavioral fear response	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10369865
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	TAS	10369865
GO:0008270	Function	Zinc ion binding	IEA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0032197	Process	Retrotransposition	IEA
GO:0040029	Process	Epigenetic regulation of gene expression	IEA
GO:0044727	Process	Epigenetic programing of male pronucleus	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0141005	Process	Transposable element silencing by heterochromatin formation	IEA
GO:2000143	Process	Negative regulation of DNA-templated transcription initiation	IEA

MIM	HGNC	e!Ensembl
603205	7198	ENSG00000114487

Q86VD1

Protein name

MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33)

Protein function

Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13589	HATPase_c_3	25 → 162		Domain
PF17942	Morc6_S5	320 → 438	Morc6 ribosomal protein S5 domain 2-like	Family
PF07496	zf-CW	482 → 528	CW-type Zinc Finger	Domain

Sequence

MDDRYPALQRAQLRLDFIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGG
FMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKK
EETMTCVFFSQTFCEEESLSEVVVPMPSWLIRTRESVTDDPQKFAMELSIIYKYSPFKTE
AELMQQFDVIYGKCGTLLVIYNLKLLLNGEPELDVKTDKEDILMAGALEDFPARWSFRAY
TSVLYFNPWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAFKDEVKKAEEAVKIAE
SILKEAQIKVNQCDRTSLSSAKDVLQRALEDVEAKQKNLKEKQRELKTARTLSLFYGVNV
ENRSQAGMFIYSNNRLIKMHEKVGSQLKLKSLLGAGVVGIVNIPLEVMEPSHNKQEFLNV
QEYNHLLKVMGQYLVQYCKDTGINNRNLTLFCNEFGYQNDIDVEKPLNSFQYQRRQAMGI
PFIIQCDLCLKWRVLPSSTNYQEKEFFDIWICANNPNRLENSCHQVECLPSIPLGTMSTI
SPSKNEKEKQLRESVIKYQNRLAEQQPQPQFIPVDEITVTSTCLTSAHKENTKTQKIRLL
GDDLKHESLSSFELSASRRGQKRNIEETDSDVEYISETKIMKKSMEEKMNSQQQRIPVAL
PENVKLAERSQRSQIANITTVWRAQPTEGCLKNAQAASWEMKRKQSLNFVEECKVLTEDE
NTSDSDIILVSDKSNTDVSLKQEKKEIPLLNQEKQELCNDVLAMKRSSSLPSWKSLLNVP
MEDVNLSSGHIARVSVSGSCKVASSPASSQSTPVKETVRKLKSKLREILLYFFPEHQLPS
ELEEPALSCELEQCPEQMNKKLKMCFNQIQNTYMVQYEKKIKRKLQSIIYDSNTRGIHNE
ISLGQCENKRKISEDKLKNLRIKLALLLQKLQLGGPEGDLEQTDTYLEALLKEDNLLFQN
NLNKVTIDARHRLPLEKNEKTSEN

Sequence length

984

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Multiple Myeloma	Associate	17312182	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35522895	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Associate	17312182	★★★★★ ★☆☆☆☆ Found in Text Mining only

MORC1 (MORC family CW-type zinc finger 1)