MORC1 (MORC family CW-type zinc finger 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27136
Gene name Gene Name - the full gene name approved by the HGNC.
MORC family CW-type zinc finger 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MORC1
Synonyms (NCBI Gene) Gene synonyms aliases
CT33, MORC, ZCW6
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies furthe
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(63)
miRTarBase ID miRNA Experiments Reference
MIRT496067 hsa-miR-106a-5p PAR-CLIP 22291592
MIRT496066 hsa-miR-106b-5p PAR-CLIP 22291592
MIRT496065 hsa-miR-17-5p PAR-CLIP 22291592
MIRT496064 hsa-miR-20a-5p PAR-CLIP 22291592
MIRT496063 hsa-miR-20b-5p PAR-CLIP 22291592
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0001662 Process Behavioral fear response IEA
GO:0001673 Component Male germ cell nucleus IEA
GO:0005634 Component Nucleus IBA 21873635
GO:0007275 Process Multicellular organism development IEA
GO:0007283 Process Spermatogenesis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
603205 7198 ENSG00000114487
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q86VD1
Protein name MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33)
Protein function Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13589 HATPase_c_3 25 → 162 Domain
PF17942 Morc6_S5 320 → 438 Morc6 ribosomal protein S5 domain 2-like Family
PF07496 zf-CW 482 → 528 CW-type Zinc Finger Domain
Sequence 
MDDRYPALQRAQLRLDFIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGG
FMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKK
EETMTCVFFSQTFCEEESLSEVVVPMPSWLIRTRESVTDDPQKFAMELSIIYKYSPFKTE
AELMQQFDVIYGKCGTLLVIYNLKLLLNGEPELDVKTDKEDILMAGALEDFPARWSFRAY
TSVLYFNPWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAFKDEVKKAEEAVKIAE
SILKEAQIKVNQCDRTSLSSAKDVLQRALEDVEAKQKNLKEKQRELKTARTLSLFYGVNV
ENRSQAGMFIYSNNRLIKMHEKVGSQLKLKSLLGAGVVGIVNIPLEVMEPSHNKQEFLNV
QEYNHLLKVMGQYLVQYCKDTGINNRNLTLFCNEFGYQNDIDVEKPLNSFQYQRRQAMGI
PFIIQCDLCLKWRVLPSSTNYQEKEFFDIWICANNPNRLENSCHQVECLPSIPLGTMSTI
SPSKNEKEKQLRESVIKYQNRLAEQQPQPQFIPVDEITVTSTCLTSAHKENTKTQKIRLL
GDDLKHESLSSFELSASRRGQKRNIEETDSDVEYISETKIMKKSMEEKMNSQQQRIPVAL
PENVKLAERSQRSQIANITTVWRAQPTEGCLKNAQAASWEMKRKQSLNFVEECKVLTEDE
NTSDSDIILVSDKSNTDVSLKQEKKEIPLLNQEKQELCNDVLAMKRSSSLPSWKSLLNVP
MEDVNLSSGHIARVSVSGSCKVASSPASSQSTPVKETVRKLKSKLREILLYFFPEHQLPS
ELEEPALSCELEQCPEQMNKKLKMCFNQIQNTYMVQYEKKIKRKLQSIIYDSNTRGIHNE
ISLGQCENKRKISEDKLKNLRIKLALLLQKLQLGGPEGDLEQTDTYLEALLKEDNLLFQN
NLNKVTIDARHRLPLEKNEKTSEN
Sequence length 984
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 25158004 ClinVar
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Show/Hide Text Mining Associations (3)
Associations from Text Mining
Disease Name Relationship Type References
Multiple Myeloma Associate 17312182
Neoplasms Associate 35522895
Testicular Neoplasms Associate 17312182