CPNE7 (copine 7)

Gene

• Entrez ID: 27132
• Gene name: Copine 7
• Gene symbol: CPNE7
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q24.3
• Summary: This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024962	hsa-miR-214-3p	Microarray;Other	19859982
MIRT906744	hsa-miR-1207-5p	CLIP-seq
MIRT906745	hsa-miR-24	CLIP-seq
MIRT906746	hsa-miR-3622b-5p	CLIP-seq
MIRT906747	hsa-miR-3918	CLIP-seq
MIRT906748	hsa-miR-4269	CLIP-seq
MIRT906749	hsa-miR-4284	CLIP-seq
MIRT906750	hsa-miR-4488	CLIP-seq
MIRT906751	hsa-miR-4514	CLIP-seq
MIRT906752	hsa-miR-4640-5p	CLIP-seq
MIRT906753	hsa-miR-4645-5p	CLIP-seq
MIRT906754	hsa-miR-4673	CLIP-seq
MIRT906755	hsa-miR-4692	CLIP-seq
MIRT906756	hsa-miR-4697-5p	CLIP-seq
MIRT906757	hsa-miR-4726-5p	CLIP-seq
MIRT906758	hsa-miR-4742-5p	CLIP-seq
MIRT906759	hsa-miR-4755-3p	CLIP-seq
MIRT906760	hsa-miR-4763-3p	CLIP-seq
MIRT906761	hsa-miR-940	CLIP-seq
MIRT2204849	hsa-miR-214	CLIP-seq
MIRT2204850	hsa-miR-3619-5p	CLIP-seq
MIRT2204851	hsa-miR-3929	CLIP-seq
MIRT2204852	hsa-miR-4419b	CLIP-seq
MIRT2204853	hsa-miR-4459	CLIP-seq
MIRT2204854	hsa-miR-4478	CLIP-seq
MIRT2204855	hsa-miR-4530	CLIP-seq
MIRT2204856	hsa-miR-4695-5p	CLIP-seq
MIRT2204857	hsa-miR-485-5p	CLIP-seq
MIRT2204858	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005634	Component	Nucleus	IDA	21087455
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	21087455
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	21087455
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	TAS	10534407
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071277	Process	Cellular response to calcium ion	IBA
GO:0071277	Process	Cellular response to calcium ion	IDA	21087455

Other IDs

• MIM: 605689
• HGNC: 2320
• e!Ensembl: ENSG00000178773

Protein

• UniProt ID: Q9UBL6
• Protein name: Copine-7 (Copine VII)
• Protein function: Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	26 → 129	C2 domain	Domain
  PF00168	C2	234 → 340	C2 domain	Domain
  PF07002	Copine	401 → 618	Copine	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the brain, testis, thymus and small intestine (PubMed:10534407, PubMed:12949241). {ECO:0000269|PubMed:10534407, ECO:0000269|PubMed:12949241}.
• Sequence:

  MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVG
  RTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQP
  AQKWLLQVVMRVSVDVLGPAGHCAKHFLCCTESSHLARTGPSFLLRYDDLCLPWATAGAV
  RWWTCRGGHTQGWQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARK
  LDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRP
  LKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVL
  ADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSV
  GEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRV
  QLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPM
  SIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLA
  EVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP

• Sequence length: 633

Pathways

Reactome:

Glycerophospholipid biosynthesis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Uncertain significance	rs145462508	RCV005932276

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Stimulate	38069026
Multiple Myeloma	Associate	33780365
Neoplasm Metastasis	Associate	38069026