Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27130
Gene name	Inversin
Gene symbol	INVS
Synonyms (NCBI Gene)	INVNPH2NPHP2
Chromosome	9
Chromosome location	9q31.1
Summary	This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocyst

Show/Hide all (35)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1052867	T>A,C	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant, synonymous variant
rs114056499	T>C	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, synonymous variant, 5 prime UTR variant
rs115042730	G>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, non coding transcript variant, missense variant
rs115754570	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs115937161	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, synonymous variant
rs116314059	A>G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs116606949	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance	Coding sequence variant, non coding transcript variant, synonymous variant
rs116686341	A>G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs121964994	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs121964995	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs140255233	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, synonymous variant
rs146901872	T>G	Conflicting-interpretations-of-pathogenicity	Missense variant, non coding transcript variant, coding sequence variant
rs147041710	G>A	Conflicting-interpretations-of-pathogenicity	Synonymous variant, non coding transcript variant, coding sequence variant
rs147112151	T>C	Conflicting-interpretations-of-pathogenicity	Synonymous variant, non coding transcript variant, coding sequence variant
rs149315279	C>A,T	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant, missense variant, synonymous variant, non coding transcript variant, coding sequence variant
rs150001738	A>G,T	Uncertain-significance, pathogenic	Missense variant, non coding transcript variant, stop gained, coding sequence variant
rs200546215	A>G	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant
rs200844390	C>A,T	Pathogenic	Stop gained, synonymous variant, non coding transcript variant, coding sequence variant
rs267607185	C>A,G,T	Benign, pathogenic	Synonymous variant, stop gained, missense variant, coding sequence variant, non coding transcript variant
rs375416014	G>A	Likely-pathogenic	Splice donor variant
rs375753623	G>A,T	Uncertain-significance, pathogenic	Splice donor variant
rs376879175	C>A,T	Uncertain-significance, pathogenic	Stop gained, synonymous variant, non coding transcript variant, coding sequence variant
rs751765105	C>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, synonymous variant
rs753348470	C>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs755288504	C>T	Likely-pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs755549444	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs769739938	->G	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant, 5 prime UTR variant
rs878855332	G>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs878855333	A>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs955421639	G>A	Likely-pathogenic	Splice donor variant
rs1322951938	T>C,G	Likely-pathogenic, uncertain-significance	Splice donor variant
rs1425211517	C>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1564123602	->CAGA	Pathogenic	5 prime UTR variant, non coding transcript variant, coding sequence variant, frameshift variant
rs1564193130	AT>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1588153872	->C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT531898	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT531897	hsa-miR-190a-5p	HITS-CLIP	23313552
MIRT531896	hsa-miR-190b	HITS-CLIP	23313552
MIRT531895	hsa-miR-92b-5p	HITS-CLIP	23313552
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT531892	hsa-miR-3689e	HITS-CLIP	23313552
MIRT531891	hsa-miR-3689f	HITS-CLIP	23313552
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT531889	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT531892	hsa-miR-3689e	HITS-CLIP	23824327
MIRT531891	hsa-miR-3689f	HITS-CLIP	23824327
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT609044	hsa-miR-3161	HITS-CLIP	23824327
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT531889	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	24906430
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	24906430
MIRT531892	hsa-miR-3689e	HITS-CLIP	24906430
MIRT531891	hsa-miR-3689f	HITS-CLIP	24906430
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT609044	hsa-miR-3161	HITS-CLIP	24906430
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT531889	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT531898	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT531897	hsa-miR-190a-5p	PAR-CLIP	22012620
MIRT531896	hsa-miR-190b	PAR-CLIP	22012620
MIRT531895	hsa-miR-92b-5p	PAR-CLIP	22012620
MIRT531894	hsa-miR-3689a-5p	PAR-CLIP	22012620
MIRT531893	hsa-miR-3689b-5p	PAR-CLIP	22012620
MIRT531892	hsa-miR-3689e	PAR-CLIP	22012620
MIRT531891	hsa-miR-3689f	PAR-CLIP	22012620
MIRT531890	hsa-miR-4648	PAR-CLIP	22012620
MIRT531888	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT531889	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT531897	hsa-miR-190a-5p	HITS-CLIP	27418678
MIRT531897	hsa-miR-190a-5p	HITS-CLIP	27418678
MIRT531897	hsa-miR-190a-5p	HITS-CLIP	27418678
MIRT531896	hsa-miR-190b	HITS-CLIP	27418678
MIRT531896	hsa-miR-190b	HITS-CLIP	27418678
MIRT531896	hsa-miR-190b	HITS-CLIP	27418678
MIRT609044	hsa-miR-3161	HITS-CLIP	27418678
MIRT609044	hsa-miR-3161	HITS-CLIP	27418678
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	27418678
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	27418678
MIRT531892	hsa-miR-3689e	HITS-CLIP	27418678
MIRT531892	hsa-miR-3689e	HITS-CLIP	27418678
MIRT531892	hsa-miR-3689e	HITS-CLIP	27418678
MIRT531892	hsa-miR-3689e	HITS-CLIP	27418678
MIRT531891	hsa-miR-3689f	HITS-CLIP	27418678
MIRT531891	hsa-miR-3689f	HITS-CLIP	27418678
MIRT531891	hsa-miR-3689f	HITS-CLIP	27418678
MIRT531891	hsa-miR-3689f	HITS-CLIP	27418678
MIRT531898	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT531898	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT531898	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT531889	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT531889	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT531889	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT531889	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT531898	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT531897	hsa-miR-190a-5p	HITS-CLIP	23313552
MIRT531896	hsa-miR-190b	HITS-CLIP	23313552
MIRT531895	hsa-miR-92b-5p	HITS-CLIP	23313552
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT531892	hsa-miR-3689e	HITS-CLIP	23313552
MIRT531891	hsa-miR-3689f	HITS-CLIP	23313552
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT531889	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT531894	hsa-miR-3689a-5p	HITS-CLIP	23824327
MIRT531893	hsa-miR-3689b-5p	HITS-CLIP	23824327
MIRT531892	hsa-miR-3689e	HITS-CLIP	23824327
MIRT531891	hsa-miR-3689f	HITS-CLIP	23824327
MIRT531888	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT609044	hsa-miR-3161	HITS-CLIP	23824327
MIRT609045	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT531889	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT531898	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT531897	hsa-miR-190a-5p	PAR-CLIP	22012620
MIRT531896	hsa-miR-190b	PAR-CLIP	22012620
MIRT531895	hsa-miR-92b-5p	PAR-CLIP	22012620
MIRT531894	hsa-miR-3689a-5p	PAR-CLIP	22012620
MIRT531893	hsa-miR-3689b-5p	PAR-CLIP	22012620
MIRT531892	hsa-miR-3689e	PAR-CLIP	22012620
MIRT531891	hsa-miR-3689f	PAR-CLIP	22012620
MIRT531890	hsa-miR-4648	PAR-CLIP	22012620
MIRT531888	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT531889	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT1068277	hsa-miR-3125	CLIP-seq
MIRT1068278	hsa-miR-3174	CLIP-seq
MIRT1068279	hsa-miR-33a	CLIP-seq
MIRT1068280	hsa-miR-33b	CLIP-seq
MIRT1068281	hsa-miR-3916	CLIP-seq
MIRT1068282	hsa-miR-4476	CLIP-seq
MIRT1068283	hsa-miR-4684-3p	CLIP-seq
MIRT1068284	hsa-miR-4691-5p	CLIP-seq
MIRT1068285	hsa-miR-4755-3p	CLIP-seq
MIRT1068286	hsa-miR-921	CLIP-seq
MIRT1068287	hsa-miR-3660	CLIP-seq
MIRT1068288	hsa-miR-4256	CLIP-seq
MIRT1068289	hsa-miR-4261	CLIP-seq
MIRT1068290	hsa-miR-4526	CLIP-seq
MIRT1068291	hsa-miR-494	CLIP-seq
MIRT1068292	hsa-miR-543	CLIP-seq
MIRT2016633	hsa-miR-510	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001822	Process	Kidney development	IBA
GO:0005515	Function	Protein binding	IPI	18371931, 21565611, 21602787, 29959317, 32814053
GO:0005516	Function	Calmodulin binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IBA
GO:0005929	Component	Cilium	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0042995	Component	Cell projection	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	18371931
GO:1904108	Process	Protein localization to ciliary inversin compartment	IBA

MIM	HGNC	e!Ensembl
243305	17870	ENSG00000119509

Q9Y283

Protein name

Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)

Protein function

Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	18 → 111	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	85 → 179	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	173 → 252	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	246 → 317	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	311 → 387	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	394 → 486	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	460 → 554	Ankyrin repeats (3 copies)	Repeat
PF00612	IQ	557 → 576	IQ calmodulin-binding motif	Motif
PF00612	IQ	917 → 937	IQ calmodulin-binding motif	Motif

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Strongly expressed in the primary cilia of renal tubular cells. {ECO:0000269|PubMed:11935322, ECO:0000269|PubMed:12872123}.

Sequence

MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR
LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL
TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV
EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL
TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN
FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA
LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD
QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA
DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI
QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE
NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG
SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP
SVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRH
DTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQNPPHHRTPRNKVTQAKL
TGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRL
QIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTAL
LLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHPTRSV
KASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP

Sequence length

1065

Interactions

View interactions

	KEGG
	Wnt signaling pathway

1182

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Infantile nephronophthisis	Pathogenic; Likely pathogenic	rs1833004339, rs935629850, rs779545419, rs2118494165, rs777723411, rs777556837, rs773049314, rs2491244807, rs2490137922, rs121964994, rs267607185, rs200844390, rs753348470, rs2491192429, rs2491236702 View all (18 more)	RCV004762277 RCV002504632 RCV002488200 RCV001780423 RCV002497887 RCV005050522 RCV002482466 RCV003219185 RCV003225660 RCV000012737 RCV000012739 RCV000012740 RCV000012741 RCV003335871 RCV003335872 RCV005051296 RCV003486324 RCV005047705 RCV005871231 RCV005051350 RCV005047728 RCV005051357 RCV005356516 RCV005040546 RCV005040604 RCV005051413 RCV001644766 RCV002499336 RCV002507430 RCV000851309 RCV000851310 RCV002489535 RCV001281145
INVS-related disorder	Likely pathogenic; Pathogenic	rs773049314, rs267607185, rs200844390, rs753348470, rs368746630, rs1179816505	RCV003911056 RCV004752702 RCV003415689 RCV003934826 RCV003391578 RCV004753736
Nephronophthisis	Pathogenic; Likely pathogenic	rs1833004339, rs935629850, rs2118799345, rs779545419, rs757019335, rs2118781593, rs763565647, rs777723411, rs2118762244, rs777556837, rs1588145141, rs773049314, rs772917131, rs755549444, rs778745264 View all (68 more)	RCV001958795 RCV001378836 RCV001377905 RCV001380935 RCV001388144 RCV001917757 RCV001962975 RCV001949543 RCV001951326 RCV002046047 RCV002042073 RCV001876509 RCV003058437 RCV001852129 RCV003112865 RCV002584120 RCV002761253 RCV002829210 RCV002857405 RCV002852101 RCV002895021 RCV003031898 RCV003037949 RCV003055293 RCV003035766 RCV000234834 RCV000234833 RCV002518920 RCV000816190 RCV001851809 RCV000234825 RCV001382990 RCV003586512 RCV003586853 RCV003587082 RCV003587581 RCV003587474 RCV003587542 RCV003587543 RCV003587604 RCV003587605 RCV003587558 RCV003587702 RCV003587703 RCV003587616 RCV003587712 RCV003587867 RCV003587913 RCV003587966 RCV003748558 RCV003748596 RCV003748535 RCV003749200 RCV003749611 RCV003750106 RCV003750127 RCV003749967 RCV003747794 RCV003747898 RCV003748789 RCV003748820 RCV003748854 RCV003748912 RCV003749675 RCV003830939 RCV003831516 RCV003861123 RCV003874174 RCV003871774 RCV003880067 RCV003881828 RCV000638094 RCV000689190 RCV000687565 RCV000819646 RCV001855632 RCV003586219 RCV000817228 RCV000826209 RCV003748288 RCV001066092 RCV001034945 RCV001209172 RCV001242107 RCV002570439

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Likely benign	rs201018893	RCV005893932
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign; Likely benign	rs577372332	RCV005867086
Colon adenocarcinoma	Benign; Likely benign	rs201018893	RCV005893931
Familial cancer of breast	Benign; Likely benign	rs201018893	RCV005893930
Gastric cancer	Benign; Likely benign	rs201018893	RCV005893934
Kidney disorder	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs147452898, rs2490088553, rs76868679, rs77465715, rs114645869, rs201136636, rs7024375	RCV002294014 RCV002294725 RCV002294048 RCV002294173 RCV002294219 RCV002294324 RCV002294323
Kidney failure	Uncertain significance; Conflicting classifications of pathogenicity	rs142606077, rs115598824	RCV005625522 RCV005625523
Lung cancer	Benign; Likely benign	rs201018893	RCV005893936
Malignant tumor of esophagus	Benign; Likely benign	rs201018893	RCV005893933
Malignant tumor of urinary bladder	Conflicting classifications of pathogenicity	rs139768159	RCV005893569
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs201018893	RCV005893935
Retinal dystrophy	Uncertain significance	rs370713515	RCV004817957

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Biliary Atresia	Associate	34750413
Carcinoma Non Small Cell Lung	Associate	28618971
Carcinoma Renal Cell	Associate	39596188
Ciliopathies	Associate	21068128, 23559409
Colorectal Neoplasms	Associate	24349560
Down Syndrome	Associate	8644714
Glomerulonephritis IGA	Inhibit	20485333
Inflammation	Associate	39596188
Kidney Diseases	Associate	28618971
Kidney Diseases Cystic	Associate	28618971
Kidney Failure Chronic	Associate	19177160
Lung Neoplasms	Associate	28618971
Lymphatic Metastasis	Stimulate	28618971
Medullary cystic kidney disease 1	Associate	12234310
Multiple Myeloma	Associate	13952722
Myeloproliferative Syndrome Transient	Associate	8644714
Neoplasm Metastasis	Associate	39596188
Neoplasms	Associate	30576868
Neoplasms	Inhibit	39596188
Nephronophthisis 2	Associate	19177160
Nephronophthisis familial juvenile	Associate	12205563, 17617513, 18076122, 28618971

INVS (inversin)