Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27122
Gene name Gene Name - the full gene name approved by the HGNC.	Dickkopf Wnt signaling pathway inhibitor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DKK3
Synonyms (NCBI Gene) Gene synonyms aliases	CRRL, REIC, RIG
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is d

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053048	hsa-miR-183-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23538390
MIRT438225	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	24325785
MIRT438225	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	24325785
MIRT438225	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	24325785
MIRT438225	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	24325785
MIRT721540	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT721539	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT721538	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT721537	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT572552	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT721536	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT721535	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT721534	hsa-miR-4775	HITS-CLIP	19536157
MIRT721533	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT721532	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT721531	hsa-miR-3120-3p	HITS-CLIP	19536157
MIRT721530	hsa-miR-4690-5p	HITS-CLIP	19536157
MIRT721529	hsa-miR-214-3p	HITS-CLIP	19536157
MIRT721528	hsa-miR-3619-5p	HITS-CLIP	19536157
MIRT721527	hsa-miR-761	HITS-CLIP	19536157
MIRT721526	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT721525	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT721524	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT721523	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT721522	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT721521	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT721520	hsa-miR-4287	HITS-CLIP	19536157
MIRT721519	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT721518	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721517	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT721516	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT572556	hsa-miR-548aa	PAR-CLIP	20371350
MIRT572555	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT572554	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT572553	hsa-miR-6793-3p	PAR-CLIP	20371350
MIRT572552	hsa-miR-942-5p	PAR-CLIP	20371350
MIRT572551	hsa-miR-2355-5p	PAR-CLIP	20371350
MIRT572550	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT572549	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT572548	hsa-miR-3679-3p	PAR-CLIP	20371350
MIRT737440	hsa-miR-125b-5p	ChIP-seq, Luciferase reporter assay, qRT-PCR, Western blot	27788486
MIRT737440	hsa-miR-125b-5p	ChIP-seq, Luciferase reporter assay, qRT-PCR, Western blot	27788486
MIRT572552	hsa-miR-942-5p	Luciferase reporter assay, Western blotting, qRT-PCR	32772782
MIRT737055	hsa-miR-483-3p	Western blotting, Microarray, qRT-PCR	31763724
MIRT737440	hsa-miR-125b-5p	Microarray, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR, In situ hybridization	31754403
MIRT735396	hsa-miR-25-3p	Luciferase reporter assay, Western blotting, Microarray, Immunoprecipitaion (IP), qRT-PCR	33723747
MIRT721540	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT721539	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT721538	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT721537	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT572552	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT721536	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT721535	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT721534	hsa-miR-4775	HITS-CLIP	19536157
MIRT721533	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT721532	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT721531	hsa-miR-3120-3p	HITS-CLIP	19536157
MIRT721530	hsa-miR-4690-5p	HITS-CLIP	19536157
MIRT721529	hsa-miR-214-3p	HITS-CLIP	19536157
MIRT721528	hsa-miR-3619-5p	HITS-CLIP	19536157
MIRT721527	hsa-miR-761	HITS-CLIP	19536157
MIRT721526	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT721525	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT721524	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT721523	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT721522	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT721521	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT721520	hsa-miR-4287	HITS-CLIP	19536157
MIRT721519	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT721518	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721517	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT721516	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT572556	hsa-miR-548aa	PAR-CLIP	20371350
MIRT572555	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT572554	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT572553	hsa-miR-6793-3p	PAR-CLIP	20371350
MIRT572552	hsa-miR-942-5p	PAR-CLIP	20371350
MIRT572551	hsa-miR-2355-5p	PAR-CLIP	20371350
MIRT572550	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT572549	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT572548	hsa-miR-3679-3p	PAR-CLIP	20371350
MIRT755753	hsa-miR-1290	Luciferase reporter assay, Western blotting, qRT-PCR	35975203
MIRT937692	hsa-miR-25	CLIP-seq
MIRT937693	hsa-miR-3185	CLIP-seq
MIRT937694	hsa-miR-32	CLIP-seq
MIRT937695	hsa-miR-363	CLIP-seq
MIRT937696	hsa-miR-367	CLIP-seq
MIRT937697	hsa-miR-3921	CLIP-seq
MIRT937698	hsa-miR-4251	CLIP-seq
MIRT937699	hsa-miR-4303	CLIP-seq
MIRT937700	hsa-miR-4327	CLIP-seq
MIRT937701	hsa-miR-4329	CLIP-seq
MIRT937702	hsa-miR-4511	CLIP-seq
MIRT937703	hsa-miR-4646-5p	CLIP-seq
MIRT937704	hsa-miR-4653-5p	CLIP-seq
MIRT937705	hsa-miR-4668-5p	CLIP-seq
MIRT937706	hsa-miR-4747-5p	CLIP-seq
MIRT937707	hsa-miR-593	CLIP-seq
MIRT937708	hsa-miR-92a	CLIP-seq
MIRT937709	hsa-miR-92b	CLIP-seq
MIRT937710	hsa-miR-2276	CLIP-seq
MIRT937711	hsa-miR-4772-3p	CLIP-seq
MIRT937697	hsa-miR-3921	CLIP-seq
MIRT937704	hsa-miR-4653-5p	CLIP-seq
MIRT2212835	hsa-miR-141	CLIP-seq
MIRT2212836	hsa-miR-200a	CLIP-seq
MIRT937692	hsa-miR-25	CLIP-seq
MIRT2212837	hsa-miR-3160-3p	CLIP-seq
MIRT937694	hsa-miR-32	CLIP-seq
MIRT2212838	hsa-miR-330-3p	CLIP-seq
MIRT937695	hsa-miR-363	CLIP-seq
MIRT937696	hsa-miR-367	CLIP-seq
MIRT2212839	hsa-miR-371-5p	CLIP-seq
MIRT937697	hsa-miR-3921	CLIP-seq
MIRT2212840	hsa-miR-450b-5p	CLIP-seq
MIRT937704	hsa-miR-4653-5p	CLIP-seq
MIRT2212841	hsa-miR-518a-5p	CLIP-seq
MIRT2212842	hsa-miR-527	CLIP-seq
MIRT937708	hsa-miR-92a	CLIP-seq
MIRT937709	hsa-miR-92b	CLIP-seq
MIRT2428235	hsa-miR-122	CLIP-seq
MIRT2428236	hsa-miR-1249	CLIP-seq
MIRT2428237	hsa-miR-1278	CLIP-seq
MIRT2428238	hsa-miR-3622a-3p	CLIP-seq
MIRT2428239	hsa-miR-3622b-3p	CLIP-seq
MIRT2428240	hsa-miR-374a	CLIP-seq
MIRT2428241	hsa-miR-374b	CLIP-seq
MIRT2428242	hsa-miR-4275	CLIP-seq
MIRT2212840	hsa-miR-450b-5p	CLIP-seq
MIRT2428243	hsa-miR-452	CLIP-seq
MIRT2428244	hsa-miR-4639-5p	CLIP-seq
MIRT2428245	hsa-miR-4676-3p	CLIP-seq
MIRT2428246	hsa-miR-4729	CLIP-seq
MIRT2428247	hsa-miR-4752	CLIP-seq
MIRT2428248	hsa-miR-500a	CLIP-seq
MIRT2428249	hsa-miR-507	CLIP-seq
MIRT2428250	hsa-miR-513a-3p	CLIP-seq
MIRT2212841	hsa-miR-518a-5p	CLIP-seq
MIRT2212842	hsa-miR-527	CLIP-seq
MIRT2428251	hsa-miR-557	CLIP-seq
MIRT2428252	hsa-miR-570	CLIP-seq
MIRT2428253	hsa-miR-579	CLIP-seq
MIRT2436840	hsa-let-7a	CLIP-seq
MIRT2436841	hsa-let-7b	CLIP-seq
MIRT2436842	hsa-let-7c	CLIP-seq
MIRT2436843	hsa-let-7d	CLIP-seq
MIRT2436844	hsa-let-7e	CLIP-seq
MIRT2436845	hsa-let-7f	CLIP-seq
MIRT2436846	hsa-let-7g	CLIP-seq
MIRT2436847	hsa-let-7i	CLIP-seq
MIRT2428235	hsa-miR-122	CLIP-seq
MIRT2212835	hsa-miR-141	CLIP-seq
MIRT2212836	hsa-miR-200a	CLIP-seq
MIRT2436848	hsa-miR-28-5p	CLIP-seq
MIRT2436849	hsa-miR-3139	CLIP-seq
MIRT2212837	hsa-miR-3160-3p	CLIP-seq
MIRT2212838	hsa-miR-330-3p	CLIP-seq
MIRT2428238	hsa-miR-3622a-3p	CLIP-seq
MIRT2428239	hsa-miR-3622b-3p	CLIP-seq
MIRT2212839	hsa-miR-371-5p	CLIP-seq
MIRT937697	hsa-miR-3921	CLIP-seq
MIRT2436850	hsa-miR-4257	CLIP-seq
MIRT2436851	hsa-miR-4279	CLIP-seq
MIRT937699	hsa-miR-4303	CLIP-seq
MIRT937700	hsa-miR-4327	CLIP-seq
MIRT2436852	hsa-miR-4419a	CLIP-seq
MIRT2436853	hsa-miR-4458	CLIP-seq
MIRT2436854	hsa-miR-4500	CLIP-seq
MIRT2212840	hsa-miR-450b-5p	CLIP-seq
MIRT2436855	hsa-miR-4510	CLIP-seq
MIRT2436856	hsa-miR-4640-3p	CLIP-seq
MIRT937704	hsa-miR-4653-5p	CLIP-seq
MIRT2436857	hsa-miR-4663	CLIP-seq
MIRT2436858	hsa-miR-4738-3p	CLIP-seq
MIRT2428247	hsa-miR-4752	CLIP-seq
MIRT2212841	hsa-miR-518a-5p	CLIP-seq
MIRT2212842	hsa-miR-527	CLIP-seq
MIRT2428252	hsa-miR-570	CLIP-seq
MIRT2428253	hsa-miR-579	CLIP-seq
MIRT2436859	hsa-miR-587	CLIP-seq
MIRT937707	hsa-miR-593	CLIP-seq
MIRT2436860	hsa-miR-646	CLIP-seq
MIRT2436861	hsa-miR-708	CLIP-seq
MIRT2436862	hsa-miR-942	CLIP-seq
MIRT2436863	hsa-miR-98	CLIP-seq
MIRT2516679	hsa-miR-105	CLIP-seq
MIRT2428235	hsa-miR-122	CLIP-seq
MIRT2516680	hsa-miR-1254	CLIP-seq
MIRT2516681	hsa-miR-1273g	CLIP-seq
MIRT2516682	hsa-miR-1275	CLIP-seq
MIRT2516683	hsa-miR-138	CLIP-seq
MIRT2516684	hsa-miR-150	CLIP-seq
MIRT2516685	hsa-miR-185	CLIP-seq
MIRT2516686	hsa-miR-29a	CLIP-seq
MIRT2516687	hsa-miR-29b	CLIP-seq
MIRT2516688	hsa-miR-29c	CLIP-seq
MIRT2516689	hsa-miR-3116	CLIP-seq
MIRT2516690	hsa-miR-3151	CLIP-seq
MIRT2212837	hsa-miR-3160-3p	CLIP-seq
MIRT2516691	hsa-miR-3161	CLIP-seq
MIRT2516692	hsa-miR-3173-5p	CLIP-seq
MIRT2516693	hsa-miR-3611	CLIP-seq
MIRT2428238	hsa-miR-3622a-3p	CLIP-seq
MIRT2428239	hsa-miR-3622b-3p	CLIP-seq
MIRT2516694	hsa-miR-3650	CLIP-seq
MIRT2516695	hsa-miR-3681	CLIP-seq
MIRT2516696	hsa-miR-377	CLIP-seq
MIRT2516697	hsa-miR-423-3p	CLIP-seq
MIRT2516698	hsa-miR-4254	CLIP-seq
MIRT2516699	hsa-miR-4255	CLIP-seq
MIRT2516700	hsa-miR-4276	CLIP-seq
MIRT2516701	hsa-miR-4300	CLIP-seq
MIRT2516702	hsa-miR-4302	CLIP-seq
MIRT2516703	hsa-miR-4306	CLIP-seq
MIRT2516704	hsa-miR-4434	CLIP-seq
MIRT2516705	hsa-miR-4447	CLIP-seq
MIRT2516706	hsa-miR-4472	CLIP-seq
MIRT2516707	hsa-miR-4494	CLIP-seq
MIRT2516708	hsa-miR-4516	CLIP-seq
MIRT2516709	hsa-miR-4522	CLIP-seq
MIRT2516710	hsa-miR-4525	CLIP-seq
MIRT2516711	hsa-miR-4531	CLIP-seq
MIRT2516712	hsa-miR-4644	CLIP-seq
MIRT2516713	hsa-miR-4665-5p	CLIP-seq
MIRT2516714	hsa-miR-4713-5p	CLIP-seq
MIRT2516715	hsa-miR-4716-5p	CLIP-seq
MIRT2516716	hsa-miR-4723-5p	CLIP-seq
MIRT2428247	hsa-miR-4752	CLIP-seq
MIRT2516717	hsa-miR-4773	CLIP-seq
MIRT2516718	hsa-miR-4786-3p	CLIP-seq
MIRT2516719	hsa-miR-491-5p	CLIP-seq
MIRT2516720	hsa-miR-511	CLIP-seq
MIRT2516721	hsa-miR-532-3p	CLIP-seq
MIRT2516722	hsa-miR-563	CLIP-seq
MIRT2428252	hsa-miR-570	CLIP-seq
MIRT2428253	hsa-miR-579	CLIP-seq
MIRT2516723	hsa-miR-625	CLIP-seq
MIRT2516724	hsa-miR-626	CLIP-seq
MIRT2516725	hsa-miR-637	CLIP-seq
MIRT2516726	hsa-miR-661	CLIP-seq
MIRT2516727	hsa-miR-920	CLIP-seq
MIRT2516728	hsa-miR-939	CLIP-seq
MIRT2516679	hsa-miR-105	CLIP-seq
MIRT2428235	hsa-miR-122	CLIP-seq
MIRT2516680	hsa-miR-1254	CLIP-seq
MIRT2516681	hsa-miR-1273g	CLIP-seq
MIRT2516682	hsa-miR-1275	CLIP-seq
MIRT2516683	hsa-miR-138	CLIP-seq
MIRT2516684	hsa-miR-150	CLIP-seq
MIRT2516685	hsa-miR-185	CLIP-seq
MIRT2516686	hsa-miR-29a	CLIP-seq
MIRT2516687	hsa-miR-29b	CLIP-seq
MIRT2516688	hsa-miR-29c	CLIP-seq
MIRT2516689	hsa-miR-3116	CLIP-seq
MIRT2516690	hsa-miR-3151	CLIP-seq
MIRT2212837	hsa-miR-3160-3p	CLIP-seq
MIRT2516691	hsa-miR-3161	CLIP-seq
MIRT2516692	hsa-miR-3173-5p	CLIP-seq
MIRT937693	hsa-miR-3185	CLIP-seq
MIRT2516693	hsa-miR-3611	CLIP-seq
MIRT2428238	hsa-miR-3622a-3p	CLIP-seq
MIRT2428239	hsa-miR-3622b-3p	CLIP-seq
MIRT2516694	hsa-miR-3650	CLIP-seq
MIRT2516695	hsa-miR-3681	CLIP-seq
MIRT2516696	hsa-miR-377	CLIP-seq
MIRT2516697	hsa-miR-423-3p	CLIP-seq
MIRT2516698	hsa-miR-4254	CLIP-seq
MIRT2516699	hsa-miR-4255	CLIP-seq
MIRT2516700	hsa-miR-4276	CLIP-seq
MIRT2516701	hsa-miR-4300	CLIP-seq
MIRT2516702	hsa-miR-4302	CLIP-seq
MIRT2516703	hsa-miR-4306	CLIP-seq
MIRT2516704	hsa-miR-4434	CLIP-seq
MIRT2516705	hsa-miR-4447	CLIP-seq
MIRT2516706	hsa-miR-4472	CLIP-seq
MIRT2679289	hsa-miR-4476	CLIP-seq
MIRT2516707	hsa-miR-4494	CLIP-seq
MIRT2212840	hsa-miR-450b-5p	CLIP-seq
MIRT2516708	hsa-miR-4516	CLIP-seq
MIRT2516709	hsa-miR-4522	CLIP-seq
MIRT2516710	hsa-miR-4525	CLIP-seq
MIRT2516711	hsa-miR-4531	CLIP-seq
MIRT2428244	hsa-miR-4639-5p	CLIP-seq
MIRT2516712	hsa-miR-4644	CLIP-seq
MIRT937703	hsa-miR-4646-5p	CLIP-seq
MIRT2516713	hsa-miR-4665-5p	CLIP-seq
MIRT2516714	hsa-miR-4713-5p	CLIP-seq
MIRT2516715	hsa-miR-4716-5p	CLIP-seq
MIRT2516716	hsa-miR-4723-5p	CLIP-seq
MIRT937706	hsa-miR-4747-5p	CLIP-seq
MIRT2428247	hsa-miR-4752	CLIP-seq
MIRT2516717	hsa-miR-4773	CLIP-seq
MIRT2516718	hsa-miR-4786-3p	CLIP-seq
MIRT2516719	hsa-miR-491-5p	CLIP-seq
MIRT2428249	hsa-miR-507	CLIP-seq
MIRT2516720	hsa-miR-511	CLIP-seq
MIRT2212841	hsa-miR-518a-5p	CLIP-seq
MIRT2212842	hsa-miR-527	CLIP-seq
MIRT2516721	hsa-miR-532-3p	CLIP-seq
MIRT2428251	hsa-miR-557	CLIP-seq
MIRT2516722	hsa-miR-563	CLIP-seq
MIRT2428252	hsa-miR-570	CLIP-seq
MIRT2428253	hsa-miR-579	CLIP-seq
MIRT2516723	hsa-miR-625	CLIP-seq
MIRT2516724	hsa-miR-626	CLIP-seq
MIRT2516725	hsa-miR-637	CLIP-seq
MIRT2516726	hsa-miR-661	CLIP-seq
MIRT2516727	hsa-miR-920	CLIP-seq
MIRT2516728	hsa-miR-939	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
MYCN	Repression	18059033;21796614

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0009653	Process	Anatomical structure morphogenesis	TAS	10570958
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	NAS	24431302
GO:0030325	Process	Adrenal gland development	IEP	12844346
GO:0032348	Process	Negative regulation of aldosterone biosynthetic process	IDA	16981135
GO:0039706	Function	Co-receptor binding	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16981135
GO:0048019	Function	Receptor antagonist activity	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	12857724
GO:1902613	Process	Negative regulation of anti-Mullerian hormone signaling pathway	TAS	24449494
GO:2000065	Process	Negative regulation of cortisol biosynthetic process	IDA	16981135
GO:2000272	Process	Negative regulation of signaling receptor activity	IEA

MIM	HGNC	e!Ensembl
605416	2893	ENSG00000050165

Protein

UniProt ID

Q9UBP4

Protein name

Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)

Protein function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04706	Dickkopf_N	146 → 196	Dickkopf N-terminal cysteine-rich region	Family

Tissue specificity

TISSUE SPECIFICITY: Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}.

Sequence

MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMED
TQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN
NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR
DSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
PREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI

Sequence length

350

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	22491018
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	15998302

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (86)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Associate	24350795, 28058013
Adrenal Cortex Diseases	Associate	28249601
Adrenocortical Carcinoma	Inhibit	28249601
Aicardi Syndrome	Inhibit	28249601
Alzheimer Disease	Stimulate	19457090
Alzheimer Disease	Associate	26119087, 35962130
Atrial Fibrillation	Associate	32809235, 34798808
Breast Neoplasms	Inhibit	18826564, 27467270
Breast Neoplasms	Associate	19570204, 23320751, 23516639, 23890219, 29843219, 30154364, 33462997, 36869893
Bronchiolitis Obliterans Syndrome	Associate	32492155
Calvarial hyperostosis	Associate	31819067
Carcinogenesis	Associate	23154266, 25484078, 28249601, 29843219, 34124998
Carcinoma Endometrioid	Associate	26397159
Carcinoma Hepatocellular	Associate	19496188, 25344678, 27014972, 32577022
Carcinoma in Situ	Inhibit	23154266
Carcinoma Renal Cell	Stimulate	25679997
Carcinoma Squamous Cell	Associate	23154266
Carcinoma Squamous Cell	Stimulate	29843219
Chromosome 1q21.1 Deletion Syndrome 1.35 Mb	Inhibit	23567267
Colonic Diseases	Associate	15858124
Colorectal Neoplasms	Stimulate	18219095
Colorectal Neoplasms	Associate	19051296, 22529687, 29476593, 29869456
Cysts	Associate	20616171
Diabetes Mellitus Type 2	Associate	33682459
Endometrial Hyperplasia	Associate	32805208
Endometrial Neoplasms	Associate	32805208
Esophageal Neoplasms	Associate	28385379
Esophageal Neoplasms	Inhibit	29843219
Esophageal Squamous Cell Carcinoma	Stimulate	22171134
Fever	Associate	27767086
Fibrosis	Associate	19496188, 35796776
Focal Epithelial Hyperplasia of the Oral Mucosa	Associate	27349317
Gallbladder Neoplasms	Associate	26715268, 33670899
Glioblastoma	Associate	18443132, 35599254, 37149563, 37434432
Glioma	Associate	18443132, 31933377, 37149563
Heart Failure	Stimulate	32809235
Heart Failure	Associate	32809235
Hereditary Breast and Ovarian Cancer Syndrome	Associate	18826564, 23890219
Hip Injuries	Inhibit	26687825
Hirschsprung Disease	Associate	33683746
Inflammation	Associate	25484078
Inflammation	Inhibit	37402316
Internal Hernia	Associate	23154266
Intestinal Neoplasms	Associate	35796776
Kidney Diseases	Associate	20616171
Leukemia Myeloid Acute	Associate	20795789, 28440495
Leukoplakia Oral	Associate	27349317
Lung Injury	Associate	37402316
Lung Neoplasms	Associate	29843219
Lymphatic Metastasis	Associate	34565005
Mammary Neoplasms Animal	Inhibit	18826564
Medulloblastoma	Associate	23567267
Melanoma	Stimulate	25484078
Melanosis	Associate	35840442
Mesothelioma Malignant	Associate	35562749
Mouth Diseases	Associate	27349317
Mouth Neoplasms	Associate	27349317
Nasopharyngeal Carcinoma	Associate	34485531
Neoplasm Metastasis	Associate	23154266, 35562749
Neoplasms	Associate	15899813, 19122685, 22961207, 23320751, 25344678, 26621187, 29674765, 29843219, 29858602, 34565005, 35562749, 35796776, 35962130
Neoplasms	Stimulate	18219095
Neoplasms	Inhibit	18443132, 19457090, 19496188, 20976069, 22071168, 22274868, 23890219, 26503968, 27349317, 27467270, 27827955, 28249601, 31561329, 31933377, 33670899, 36869893 View all (1 more)
Oral Submucous Fibrosis	Associate	27349317
Osteoarthritis	Stimulate	26687825
Osteoarthritis Knee	Associate	35137918
Ovarian Diseases	Associate	29843219
Ovarian Neoplasms	Associate	27806724
Pancreatic Neoplasms	Associate	16036106
Pancreatic Neoplasms	Inhibit	21987623
Personality Disorders	Associate	33670899
Pneumonia	Associate	37402316
Polycystic Kidney Autosomal Dominant	Associate	20616171
Prostatic Hyperplasia	Stimulate	29858602
Prostatic Neoplasms	Associate	15899813, 20976069, 23538390, 26503968, 26621187, 26658102, 26689513, 27767086, 30779066, 31115550, 31819067, 35303365
Prostatic Neoplasms	Stimulate	22071168
Prostatic Neoplasms	Inhibit	29858602
Prostatitis	Associate	22071168, 29858602
Schizophrenia	Inhibit	15998302
Spondylarthropathies	Associate	24330574
Squamous Cell Carcinoma of Head and Neck	Associate	27349317, 33281184
Stomach Neoplasms	Associate	19051296, 31561329, 34124998, 34565005
Stomach Neoplasms	Inhibit	29843219
Tongue Neoplasms	Associate	30246484
Urinary Bladder Neoplasms	Associate	19122685
Urinary Bladder Neoplasms	Stimulate	27827955
Uterine Cervical Neoplasms	Associate	22961207

DKK3 (dickkopf Wnt signaling pathway inhibitor 3)