Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	27113
Gene name	BCL2 binding component 3
Gene symbol	BBC3
Synonyms (NCBI Gene)	JFY-1JFY1PUMA
Chromosome	19
Chromosome location	19q13.32
Summary	This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004500	hsa-miR-483-3p	qRT-PCRLuciferase reporter assayWestern blotNorthern blot	20388800
MIRT003367	hsa-miR-221-3p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayNorthern blotWestern blot	20813046
MIRT005369	hsa-miR-222-3p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayNorthern blotWestern blot	20813046
MIRT005915	hsa-miR-125b-5p	Luciferase reporter assayqRT-PCRWestern blot	20886540
MIRT006683	hsa-miR-296-5p	Luciferase reporter assayqRT-PCRWestern blot	21633093
MIRT003367	hsa-miR-221-3p	Luciferase reporter assay	21042732
MIRT005369	hsa-miR-222-3p	Luciferase reporter assay	21042732
MIRT016253	hsa-miR-504-5p	qRT-PCR	20542001
MIRT003367	hsa-miR-221-3p	Reporter assay;Microarray	20018759
MIRT003367	hsa-miR-221-3p	Luciferase reporter assayqRT-PCRWestern blot	22075712
MIRT003367	hsa-miR-221-3p	qRT-PCRWestern blotReporter assay	22075712
MIRT005369	hsa-miR-222-3p	qRT-PCRWestern blotReporter assay	22075712
MIRT438653	hsa-miR-149-5p	ImmunofluorescenceLuciferase reporter assayNorthern blotqRT-PCRWestern blot	23873935
MIRT438653	hsa-miR-149-5p	ImmunofluorescenceLuciferase reporter assayNorthern blotqRT-PCRWestern blot	23873935
MIRT005369	hsa-miR-222-3p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	24452416
MIRT438653	hsa-miR-149-5p	ImmunofluorescenceLuciferase reporter assayNorthern blotqRT-PCRWestern blot	23873935
MIRT438653	hsa-miR-149-5p	ImmunofluorescenceLuciferase reporter assayNorthern blotqRT-PCRWestern blot	23873935
MIRT005369	hsa-miR-222-3p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	24452416
MIRT481013	hsa-miR-6088	PAR-CLIP	24398324
MIRT481012	hsa-miR-143-3p	PAR-CLIP	24398324
MIRT481010	hsa-miR-4770	PAR-CLIP	24398324
MIRT481011	hsa-miR-4324	PAR-CLIP	24398324
MIRT480971	hsa-miR-544b	PAR-CLIP	24398324
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	24398324
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	24398324
MIRT481007	hsa-miR-1273f	PAR-CLIP	24398324
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	24398324
MIRT481003	hsa-miR-541-3p	PAR-CLIP	24398324
MIRT481002	hsa-miR-654-5p	PAR-CLIP	24398324
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	24398324
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	24398324
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	24398324
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	24398324
MIRT480997	hsa-miR-876-3p	PAR-CLIP	24398324
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	24398324
MIRT480995	hsa-miR-1200	PAR-CLIP	24398324
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	24398324
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	24398324
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	24398324
MIRT480990	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT480988	hsa-miR-759	PAR-CLIP	23592263
MIRT480987	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT480986	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480982	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT480981	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT005614	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT480980	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT480979	hsa-miR-4779	PAR-CLIP	23592263
MIRT480978	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT480977	hsa-miR-4459	PAR-CLIP	23592263
MIRT480976	hsa-miR-665	PAR-CLIP	23592263
MIRT480975	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT480974	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT480973	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT480972	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT480969	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480966	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT480965	hsa-miR-765	PAR-CLIP	23592263
MIRT480963	hsa-miR-4271	PAR-CLIP	23592263
MIRT480962	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT480961	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT480960	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT480959	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT480958	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT481013	hsa-miR-6088	PAR-CLIP	23592263
MIRT481012	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT481010	hsa-miR-4770	PAR-CLIP	23592263
MIRT481011	hsa-miR-4324	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	23592263
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT481007	hsa-miR-1273f	PAR-CLIP	23592263
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT481003	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481002	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT480997	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	23592263
MIRT480995	hsa-miR-1200	PAR-CLIP	23592263
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	23592263
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	23592263
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT481013	hsa-miR-6088	PAR-CLIP	23592263
MIRT481012	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT481010	hsa-miR-4770	PAR-CLIP	23592263
MIRT481011	hsa-miR-4324	PAR-CLIP	23592263
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	23592263
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT481007	hsa-miR-1273f	PAR-CLIP	23592263
MIRT481006	hsa-miR-6087	PAR-CLIP	23592263
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT481004	hsa-miR-4767	PAR-CLIP	23592263
MIRT481003	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481002	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT480997	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	23592263
MIRT480995	hsa-miR-1200	PAR-CLIP	23592263
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	23592263
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	23592263
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT480991	hsa-miR-4523	PAR-CLIP	23592263
MIRT480990	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT480989	hsa-miR-3943	PAR-CLIP	23592263
MIRT480988	hsa-miR-759	PAR-CLIP	23592263
MIRT480987	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT480986	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT480985	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT480984	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT480983	hsa-miR-4784	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480982	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT480981	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT005614	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT480980	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT480979	hsa-miR-4779	PAR-CLIP	23592263
MIRT480978	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT480977	hsa-miR-4459	PAR-CLIP	23592263
MIRT480976	hsa-miR-665	PAR-CLIP	23592263
MIRT480975	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT480974	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT480973	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT480972	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT480969	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480966	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT480965	hsa-miR-765	PAR-CLIP	23592263
MIRT480964	hsa-miR-2861	PAR-CLIP	23592263
MIRT480963	hsa-miR-4271	PAR-CLIP	23592263
MIRT480962	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT480961	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT480960	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT480959	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT480958	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT004500	hsa-miR-483-3p	MicroarrayqRT-PCRWestern blot	27120784
MIRT003367	hsa-miR-221-3p	ImmunoblotIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRAGO2 binding RNA immunoprecipitation qRT-PCR	26249174
MIRT003367	hsa-miR-221-3p	ImmunoblotIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRAGO2 binding RNA immunoprecipitation qRT-PCR	26249174
MIRT005369	hsa-miR-222-3p	ImmunoblotIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRAGO2 binding RNA immunoprecipitation qRT-PCR	26249174
MIRT005369	hsa-miR-222-3p	ImmunoblotIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRAGO2 binding RNA immunoprecipitation qRT-PCR	26249174
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	26701625
MIRT481007	hsa-miR-1273f	PAR-CLIP	26701625
MIRT481007	hsa-miR-1273f	PAR-CLIP	26701625
MIRT481012	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT481012	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	26701625
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	26701625
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481004	hsa-miR-4767	PAR-CLIP	26701625
MIRT481010	hsa-miR-4770	PAR-CLIP	26701625
MIRT481010	hsa-miR-4770	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481003	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481006	hsa-miR-6087	PAR-CLIP	26701625
MIRT481013	hsa-miR-6088	PAR-CLIP	26701625
MIRT481013	hsa-miR-6088	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481002	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT480997	hsa-miR-876-3p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT003367	hsa-miR-221-3p	qRT-PCR	33336275
MIRT004500	hsa-miR-483-3p	Luciferase reporter assayWestern blottingNorthern blottingqRT-PCRin vivo gain/loss-of-function experiments	20388800
MIRT004500	hsa-miR-483-3p	Luciferase reporter assayWestern blottingMicroarrayin vitro cullelar assaysqRT-PCR	21859927
MIRT481013	hsa-miR-6088	PAR-CLIP	24398324
MIRT481012	hsa-miR-143-3p	PAR-CLIP	24398324
MIRT481010	hsa-miR-4770	PAR-CLIP	24398324
MIRT481011	hsa-miR-4324	PAR-CLIP	24398324
MIRT480971	hsa-miR-544b	PAR-CLIP	24398324
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	24398324
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	24398324
MIRT481007	hsa-miR-1273f	PAR-CLIP	24398324
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	24398324
MIRT481003	hsa-miR-541-3p	PAR-CLIP	24398324
MIRT481002	hsa-miR-654-5p	PAR-CLIP	24398324
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	24398324
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	24398324
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	24398324
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	24398324
MIRT480997	hsa-miR-876-3p	PAR-CLIP	24398324
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	24398324
MIRT480995	hsa-miR-1200	PAR-CLIP	24398324
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	24398324
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	24398324
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	24398324
MIRT480990	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT480988	hsa-miR-759	PAR-CLIP	23592263
MIRT480987	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT480986	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480982	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT480981	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT005614	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT480980	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT480979	hsa-miR-4779	PAR-CLIP	23592263
MIRT480978	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT480977	hsa-miR-4459	PAR-CLIP	23592263
MIRT480976	hsa-miR-665	PAR-CLIP	23592263
MIRT480975	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT480974	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT480973	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT480972	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT480969	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480966	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT480965	hsa-miR-765	PAR-CLIP	23592263
MIRT480963	hsa-miR-4271	PAR-CLIP	23592263
MIRT480962	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT480961	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT480960	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT480959	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT480958	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT481013	hsa-miR-6088	PAR-CLIP	23592263
MIRT481012	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT481010	hsa-miR-4770	PAR-CLIP	23592263
MIRT481011	hsa-miR-4324	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	23592263
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT481007	hsa-miR-1273f	PAR-CLIP	23592263
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT481003	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481002	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT480997	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	23592263
MIRT480995	hsa-miR-1200	PAR-CLIP	23592263
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	23592263
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	23592263
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT481013	hsa-miR-6088	PAR-CLIP	23592263
MIRT481012	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT481010	hsa-miR-4770	PAR-CLIP	23592263
MIRT481011	hsa-miR-4324	PAR-CLIP	23592263
MIRT481009	hsa-miR-3124-3p	PAR-CLIP	23592263
MIRT481008	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT481007	hsa-miR-1273f	PAR-CLIP	23592263
MIRT481006	hsa-miR-6087	PAR-CLIP	23592263
MIRT481005	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT481004	hsa-miR-4767	PAR-CLIP	23592263
MIRT481003	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT481002	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT481001	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT481000	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT480999	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT480998	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT480997	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT480996	hsa-miR-378a-5p	PAR-CLIP	23592263
MIRT480995	hsa-miR-1200	PAR-CLIP	23592263
MIRT480994	hsa-miR-1228-5p	PAR-CLIP	23592263
MIRT480993	hsa-miR-3074-5p	PAR-CLIP	23592263
MIRT480992	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT480991	hsa-miR-4523	PAR-CLIP	23592263
MIRT480990	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT480989	hsa-miR-3943	PAR-CLIP	23592263
MIRT480988	hsa-miR-759	PAR-CLIP	23592263
MIRT480987	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT480986	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT480985	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT480984	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT480983	hsa-miR-4784	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480982	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT480981	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT005614	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT480980	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT480979	hsa-miR-4779	PAR-CLIP	23592263
MIRT480978	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT480977	hsa-miR-4459	PAR-CLIP	23592263
MIRT480976	hsa-miR-665	PAR-CLIP	23592263
MIRT480975	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT480974	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT480973	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT480972	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT480971	hsa-miR-544b	PAR-CLIP	23592263
MIRT480969	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT480970	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT480968	hsa-miR-6089	PAR-CLIP	23592263
MIRT480967	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT480966	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT480965	hsa-miR-765	PAR-CLIP	23592263
MIRT480964	hsa-miR-2861	PAR-CLIP	23592263
MIRT480963	hsa-miR-4271	PAR-CLIP	23592263
MIRT480962	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT480961	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT480960	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT480959	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT480958	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT816632	hsa-miR-101	CLIP-seq
MIRT816633	hsa-miR-1184	CLIP-seq
MIRT816634	hsa-miR-1207-3p	CLIP-seq
MIRT816635	hsa-miR-122	CLIP-seq
MIRT816636	hsa-miR-1226	CLIP-seq
MIRT816637	hsa-miR-1289	CLIP-seq
MIRT816638	hsa-miR-1298	CLIP-seq
MIRT816639	hsa-miR-1301	CLIP-seq
MIRT816640	hsa-miR-139-5p	CLIP-seq
MIRT816641	hsa-miR-144	CLIP-seq
MIRT816642	hsa-miR-148a	CLIP-seq
MIRT816643	hsa-miR-148b	CLIP-seq
MIRT816644	hsa-miR-152	CLIP-seq
MIRT816645	hsa-miR-1587	CLIP-seq
MIRT816646	hsa-miR-1910	CLIP-seq
MIRT816647	hsa-miR-199a-5p	CLIP-seq
MIRT816648	hsa-miR-199b-5p	CLIP-seq
MIRT816649	hsa-miR-24	CLIP-seq
MIRT816650	hsa-miR-3120-3p	CLIP-seq
MIRT816651	hsa-miR-3135b	CLIP-seq
MIRT816652	hsa-miR-3605-3p	CLIP-seq
MIRT816653	hsa-miR-3652	CLIP-seq
MIRT816654	hsa-miR-378g	CLIP-seq
MIRT816655	hsa-miR-4283	CLIP-seq
MIRT816656	hsa-miR-4430	CLIP-seq
MIRT816657	hsa-miR-4433	CLIP-seq
MIRT816658	hsa-miR-4438	CLIP-seq
MIRT816659	hsa-miR-4489	CLIP-seq
MIRT816660	hsa-miR-4492	CLIP-seq
MIRT816661	hsa-miR-4498	CLIP-seq
MIRT816662	hsa-miR-4505	CLIP-seq
MIRT816663	hsa-miR-4656	CLIP-seq
MIRT816664	hsa-miR-4660	CLIP-seq
MIRT816665	hsa-miR-4663	CLIP-seq
MIRT816666	hsa-miR-4664-3p	CLIP-seq
MIRT816667	hsa-miR-4675	CLIP-seq
MIRT816668	hsa-miR-4697-3p	CLIP-seq
MIRT816669	hsa-miR-4728-3p	CLIP-seq
MIRT816670	hsa-miR-4731-5p	CLIP-seq
MIRT816671	hsa-miR-4741	CLIP-seq
MIRT816672	hsa-miR-4760-3p	CLIP-seq
MIRT816673	hsa-miR-503	CLIP-seq
MIRT816674	hsa-miR-5047	CLIP-seq
MIRT816675	hsa-miR-5095	CLIP-seq
MIRT816676	hsa-miR-597	CLIP-seq
MIRT816677	hsa-miR-600	CLIP-seq
MIRT816678	hsa-miR-604	CLIP-seq
MIRT816679	hsa-miR-634	CLIP-seq
MIRT816680	hsa-miR-647	CLIP-seq
MIRT816681	hsa-miR-664	CLIP-seq
MIRT816682	hsa-miR-711	CLIP-seq
MIRT816683	hsa-miR-762	CLIP-seq
MIRT816632	hsa-miR-101	CLIP-seq
MIRT816635	hsa-miR-122	CLIP-seq
MIRT816638	hsa-miR-1298	CLIP-seq
MIRT816640	hsa-miR-139-5p	CLIP-seq
MIRT816641	hsa-miR-144	CLIP-seq
MIRT816684	hsa-miR-1913	CLIP-seq
MIRT816650	hsa-miR-3120-3p	CLIP-seq
MIRT816651	hsa-miR-3135b	CLIP-seq
MIRT816685	hsa-miR-324-3p	CLIP-seq
MIRT816686	hsa-miR-3647-3p	CLIP-seq
MIRT816653	hsa-miR-3652	CLIP-seq
MIRT816655	hsa-miR-4283	CLIP-seq
MIRT816656	hsa-miR-4430	CLIP-seq
MIRT816659	hsa-miR-4489	CLIP-seq
MIRT816660	hsa-miR-4492	CLIP-seq
MIRT816661	hsa-miR-4498	CLIP-seq
MIRT816666	hsa-miR-4664-3p	CLIP-seq
MIRT816687	hsa-miR-4707-5p	CLIP-seq
MIRT816672	hsa-miR-4760-3p	CLIP-seq
MIRT816673	hsa-miR-503	CLIP-seq
MIRT816677	hsa-miR-600	CLIP-seq
MIRT816678	hsa-miR-604	CLIP-seq
MIRT816680	hsa-miR-647	CLIP-seq
MIRT816681	hsa-miR-664	CLIP-seq
MIRT816683	hsa-miR-762	CLIP-seq
MIRT1941519	hsa-miR-143	CLIP-seq
MIRT816649	hsa-miR-24	CLIP-seq
MIRT1941520	hsa-miR-4667-3p	CLIP-seq
MIRT1941521	hsa-miR-642a	CLIP-seq
MIRT816632	hsa-miR-101	CLIP-seq
MIRT2180259	hsa-miR-1236	CLIP-seq
MIRT816638	hsa-miR-1298	CLIP-seq
MIRT816640	hsa-miR-139-5p	CLIP-seq
MIRT1941519	hsa-miR-143	CLIP-seq
MIRT816641	hsa-miR-144	CLIP-seq
MIRT2180260	hsa-miR-1470	CLIP-seq
MIRT816649	hsa-miR-24	CLIP-seq
MIRT816650	hsa-miR-3120-3p	CLIP-seq
MIRT2180261	hsa-miR-323-5p	CLIP-seq
MIRT2180262	hsa-miR-3545-5p	CLIP-seq
MIRT816686	hsa-miR-3647-3p	CLIP-seq
MIRT816658	hsa-miR-4438	CLIP-seq
MIRT2180263	hsa-miR-4469	CLIP-seq
MIRT816662	hsa-miR-4505	CLIP-seq
MIRT2180264	hsa-miR-4529-5p	CLIP-seq
MIRT2180265	hsa-miR-4640-5p	CLIP-seq
MIRT816666	hsa-miR-4664-3p	CLIP-seq
MIRT1941520	hsa-miR-4667-3p	CLIP-seq
MIRT2180266	hsa-miR-4726-5p	CLIP-seq
MIRT816672	hsa-miR-4760-3p	CLIP-seq
MIRT816673	hsa-miR-503	CLIP-seq
MIRT816675	hsa-miR-5095	CLIP-seq
MIRT2180267	hsa-miR-541	CLIP-seq
MIRT816677	hsa-miR-600	CLIP-seq
MIRT1941521	hsa-miR-642a	CLIP-seq
MIRT816681	hsa-miR-664	CLIP-seq
MIRT816662	hsa-miR-4505	CLIP-seq
MIRT816637	hsa-miR-1289	CLIP-seq
MIRT2435635	hsa-miR-149	CLIP-seq
MIRT816662	hsa-miR-4505	CLIP-seq
MIRT2435636	hsa-miR-940	CLIP-seq

Show/Hide all (8)

Transcription factor	Regulation	Reference
CTCF	Unknown	20818159
E2F1	Activation	17263886
ETV6	Activation	16828711
FOXO3	Unknown	21654193
TCF3	Repression	23684607
TP53	Activation	17280505
TP53	Unknown	11572983;15988033;18755897;22763818
TP73	Activation	17700533

Show/Hide all (52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001836	Process	Release of cytochrome c from mitochondria	IBA
GO:0001836	Process	Release of cytochrome c from mitochondria	IDA	11463392
GO:0005515	Function	Protein binding	IPI	11463391, 11463392, 15694340, 16151013, 16608847, 16697956, 17177603, 17289999, 20153921, 20627101, 22516262, 26212789, 26431330, 28514442, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	11463391, 11463392
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	26212789
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005764	Component	Lysosome	IDA	26212789
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IMP	26212789
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	ISS
GO:0008340	Process	Determination of adult lifespan	IEA
GO:0008340	Process	Determination of adult lifespan	ISS
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	21041309
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	22761832
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0042771	Process	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	ISS
GO:0044346	Process	Fibroblast apoptotic process	IEA
GO:0051117	Function	ATPase binding	IPI	26212789
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	16407291
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS
GO:0070227	Process	Lymphocyte apoptotic process	IEA
GO:0070230	Process	Positive regulation of lymphocyte apoptotic process	IEA
GO:0070231	Process	T cell apoptotic process	IEA
GO:0070234	Process	Positive regulation of T cell apoptotic process	IEA
GO:0070245	Process	Positive regulation of thymocyte apoptotic process	IEA
GO:0070245	Process	Positive regulation of thymocyte apoptotic process	ISS
GO:0071456	Process	Cellular response to hypoxia	IEP	20810912
GO:0071479	Process	Cellular response to ionizing radiation	IEA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IBA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IEA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IGI	21041309
GO:0097190	Process	Apoptotic signaling pathway	IDA	11463392
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IDA	17024184
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IEA
GO:0097194	Process	Execution phase of apoptosis	IBA
GO:0097194	Process	Execution phase of apoptosis	IDA	11463391, 11463392
GO:1902237	Process	Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	TAS	22013210
GO:1903749	Process	Positive regulation of establishment of protein localization to mitochondrion	IEA
GO:1903896	Process	Positive regulation of IRE1-mediated unfolded protein response	TAS	22013210
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IEA
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IMP	17289999, 27031958
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	ISS

MIM	HGNC	e!Ensembl
605854	17868	ENSG00000105327

Q96PG8

Protein name

Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)

Protein function

[Isoform 3]: Does not affect cell growth.

Family and domains

Sequence

MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLP
ARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAP
RPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGG
RPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDS
GGRPLPPPDTLASAGDFLCTM

Sequence length

261

Q9BXH1

Protein name

Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)

Protein function

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubM

PDB

2M04 , 4BPI , 4BPJ , 4BPK , 4HNJ , 5UUL , 6QFM , 6QG8 , 6TQP , 7DVD , 7P0S , 7P9W , 7QTX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15826	PUMA	2 → 193	Bcl-2-binding component 3, p53 upregulated modulator of apoptosis	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11463391}.

Sequence

MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLC
APTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPT
QAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLP
LPRGHRAPEMEPN

Sequence length

193

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Hippo signaling pathway Huntington disease Measles Pathways in cancer Colorectal cancer		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes

BBC3 (BCL2 binding component 3)