TRAPPC3 (trafficking protein particle complex subunit 3)

Gene

• Entrez ID: 27095
• Gene name: Trafficking protein particle complex subunit 3
• Gene symbol: TRAPPC3
• Synonyms (NCBI Gene): BET3
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. A

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs751375244	G>A	Likely-pathogenic	Coding sequence variant, intron variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002767	hsa-miR-1-3p	Microarray	15685193
MIRT002767	hsa-miR-1-3p	Microarray;Other	15685193
MIRT030205	hsa-miR-26b-5p	Microarray	19088304
MIRT1452045	hsa-miR-1265	CLIP-seq
MIRT1452046	hsa-miR-1299	CLIP-seq
MIRT1452047	hsa-miR-2467-3p	CLIP-seq
MIRT1452048	hsa-miR-3140-5p	CLIP-seq
MIRT1452049	hsa-miR-3607-3p	CLIP-seq
MIRT1452050	hsa-miR-3616-3p	CLIP-seq
MIRT1452051	hsa-miR-3686	CLIP-seq
MIRT1452052	hsa-miR-370	CLIP-seq
MIRT1452053	hsa-miR-410	CLIP-seq
MIRT1452054	hsa-miR-4419a	CLIP-seq
MIRT1452055	hsa-miR-4436b-3p	CLIP-seq
MIRT1452056	hsa-miR-4510	CLIP-seq
MIRT1452057	hsa-miR-4643	CLIP-seq
MIRT1452058	hsa-miR-4694-3p	CLIP-seq
MIRT1452059	hsa-miR-4716-5p	CLIP-seq
MIRT1452060	hsa-miR-4717-3p	CLIP-seq
MIRT1452061	hsa-miR-4782-5p	CLIP-seq
MIRT1452062	hsa-miR-516b	CLIP-seq
MIRT1452063	hsa-miR-522	CLIP-seq
MIRT1452064	hsa-miR-583	CLIP-seq
MIRT1452065	hsa-miR-622	CLIP-seq
MIRT1452066	hsa-miR-767-3p	CLIP-seq
MIRT1452046	hsa-miR-1299	CLIP-seq
MIRT1452047	hsa-miR-2467-3p	CLIP-seq
MIRT1452050	hsa-miR-3616-3p	CLIP-seq
MIRT1452052	hsa-miR-370	CLIP-seq
MIRT1452054	hsa-miR-4419a	CLIP-seq
MIRT1452055	hsa-miR-4436b-3p	CLIP-seq
MIRT1452056	hsa-miR-4510	CLIP-seq
MIRT1452061	hsa-miR-4782-5p	CLIP-seq
MIRT1452062	hsa-miR-516b	CLIP-seq
MIRT2356412	hsa-miR-4749-3p	CLIP-seq
MIRT2649988	hsa-miR-1227	CLIP-seq
MIRT2649989	hsa-miR-1293	CLIP-seq
MIRT2649990	hsa-miR-129-3p	CLIP-seq
MIRT2649991	hsa-miR-1304	CLIP-seq
MIRT2649992	hsa-miR-1343	CLIP-seq
MIRT2649993	hsa-miR-135a	CLIP-seq
MIRT2649994	hsa-miR-135b	CLIP-seq
MIRT2649995	hsa-miR-1470	CLIP-seq
MIRT2649996	hsa-miR-1827	CLIP-seq
MIRT2649997	hsa-miR-1915	CLIP-seq
MIRT2649998	hsa-miR-3074-5p	CLIP-seq
MIRT2649999	hsa-miR-3119	CLIP-seq
MIRT2650000	hsa-miR-3124-3p	CLIP-seq
MIRT2650001	hsa-miR-3128	CLIP-seq
MIRT1452048	hsa-miR-3140-5p	CLIP-seq
MIRT2650002	hsa-miR-3160-5p	CLIP-seq
MIRT2650003	hsa-miR-3651	CLIP-seq
MIRT2650004	hsa-miR-3661	CLIP-seq
MIRT2650005	hsa-miR-3667-3p	CLIP-seq
MIRT2650006	hsa-miR-3908	CLIP-seq
MIRT2650007	hsa-miR-3942-5p	CLIP-seq
MIRT2650008	hsa-miR-4263	CLIP-seq
MIRT2650009	hsa-miR-4286	CLIP-seq
MIRT2650010	hsa-miR-4448	CLIP-seq
MIRT2650011	hsa-miR-4469	CLIP-seq
MIRT2650012	hsa-miR-4470	CLIP-seq
MIRT2650013	hsa-miR-4483	CLIP-seq
MIRT2650014	hsa-miR-4484	CLIP-seq
MIRT2650015	hsa-miR-4509	CLIP-seq
MIRT2650016	hsa-miR-455-5p	CLIP-seq
MIRT1452057	hsa-miR-4643	CLIP-seq
MIRT2650017	hsa-miR-4667-3p	CLIP-seq
MIRT2650018	hsa-miR-4691-5p	CLIP-seq
MIRT1452058	hsa-miR-4694-3p	CLIP-seq
MIRT2650019	hsa-miR-4703-5p	CLIP-seq
MIRT1452060	hsa-miR-4717-3p	CLIP-seq
MIRT2650020	hsa-miR-4744	CLIP-seq
MIRT2650021	hsa-miR-4766-3p	CLIP-seq
MIRT2650022	hsa-miR-4799-5p	CLIP-seq
MIRT1452063	hsa-miR-522	CLIP-seq
MIRT2650023	hsa-miR-548an	CLIP-seq
MIRT2650024	hsa-miR-576-3p	CLIP-seq
MIRT2650025	hsa-miR-576-5p	CLIP-seq
MIRT2650026	hsa-miR-592	CLIP-seq
MIRT2650027	hsa-miR-597	CLIP-seq
MIRT2650028	hsa-miR-621	CLIP-seq
MIRT1452065	hsa-miR-622	CLIP-seq
MIRT2650029	hsa-miR-631	CLIP-seq
MIRT1452066	hsa-miR-767-3p	CLIP-seq
MIRT2650030	hsa-miR-769-5p	CLIP-seq
MIRT2649989	hsa-miR-1293	CLIP-seq
MIRT2649990	hsa-miR-129-3p	CLIP-seq
MIRT2649991	hsa-miR-1304	CLIP-seq
MIRT2649992	hsa-miR-1343	CLIP-seq
MIRT2649993	hsa-miR-135a	CLIP-seq
MIRT2649994	hsa-miR-135b	CLIP-seq
MIRT2649995	hsa-miR-1470	CLIP-seq
MIRT2649996	hsa-miR-1827	CLIP-seq
MIRT2649998	hsa-miR-3074-5p	CLIP-seq
MIRT2649999	hsa-miR-3119	CLIP-seq
MIRT2650000	hsa-miR-3124-3p	CLIP-seq
MIRT2650001	hsa-miR-3128	CLIP-seq
MIRT2650002	hsa-miR-3160-5p	CLIP-seq
MIRT2650003	hsa-miR-3651	CLIP-seq
MIRT2650004	hsa-miR-3661	CLIP-seq
MIRT2650005	hsa-miR-3667-3p	CLIP-seq
MIRT2650006	hsa-miR-3908	CLIP-seq
MIRT2650007	hsa-miR-3942-5p	CLIP-seq
MIRT2650008	hsa-miR-4263	CLIP-seq
MIRT2650009	hsa-miR-4286	CLIP-seq
MIRT2694102	hsa-miR-4302	CLIP-seq
MIRT2650010	hsa-miR-4448	CLIP-seq
MIRT2650011	hsa-miR-4469	CLIP-seq
MIRT2650012	hsa-miR-4470	CLIP-seq
MIRT2650013	hsa-miR-4483	CLIP-seq
MIRT2650015	hsa-miR-4509	CLIP-seq
MIRT2650017	hsa-miR-4667-3p	CLIP-seq
MIRT2650018	hsa-miR-4691-5p	CLIP-seq
MIRT2694103	hsa-miR-4697-3p	CLIP-seq
MIRT2650019	hsa-miR-4703-5p	CLIP-seq
MIRT2650020	hsa-miR-4744	CLIP-seq
MIRT2650021	hsa-miR-4766-3p	CLIP-seq
MIRT2694104	hsa-miR-4786-5p	CLIP-seq
MIRT2650022	hsa-miR-4799-5p	CLIP-seq
MIRT2650025	hsa-miR-576-5p	CLIP-seq
MIRT2650026	hsa-miR-592	CLIP-seq
MIRT2650027	hsa-miR-597	CLIP-seq
MIRT2650028	hsa-miR-621	CLIP-seq
MIRT1452065	hsa-miR-622	CLIP-seq
MIRT2650029	hsa-miR-631	CLIP-seq
MIRT1452066	hsa-miR-767-3p	CLIP-seq
MIRT2650030	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16828797, 16908848, 18930054, 21453443, 21525244, 21827752, 25416956, 28514442, 31515488, 32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA	21873635
GO:0030008	Component	TRAPP complex	IBA	21873635
GO:0030008	Component	TRAPP complex	IDA	21525244
GO:0033106	Component	Cis-Golgi network membrane	IBA	21873635
GO:0048208	Process	COPII vesicle coating	TAS

Other IDs

• MIM: 610955
• HGNC: 19942
• e!Ensembl: ENSG00000054116

Protein

• UniProt ID: O43617
• Protein name: Trafficking protein particle complex subunit 3 (BET3 homolog)
• Protein function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
• PDB: 1SZ7, 2C0J, 2CFH, 3KXC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04051	TRAPP	19 → 166	Transport protein particle (TRAPP) component	Family

• Sequence:

  MSRQANRGTESKKMSSELFTLTYGALVTQLCKDYENDEDVNKQLDKMGFNIGVRLIEDFL
  ARSNVGRCHDFRETADVIAKVAFKMYLGITPSITNWSPAGDEFSLILENNPLVDFVELPD
  NHSSLIYSNLLCGVLRGALEMVQMAVEAKFVQDTLKGDGVTEIRMRFIRRIEDNLPAGEE
  

• Sequence length: 180

Pathways

Reactome:

COPII-mediated vesicle transport
RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Bardet-biedl syndrome	Bardet-Biedl Syndrome	rs397704728, rs397515335, rs397515337, rs267607031, rs121918327, rs587777801, rs587777802, rs121918328, rs587777803, rs549625604, rs137852837, rs137852833, rs137852835, rs267606719, rs199874059, rs587777804, rs104893678, rs104893679, rs104893680, rs104893681, rs587777806, rs587777807, rs119103286, rs587777808, rs201938124, rs137852856, rs587777810, rs137852857, rs137852858, rs587777811, rs606231137, rs119466001, rs119466002, rs587777812, rs587777824, rs121908174, rs121908175, rs121908176, rs121908177, rs121908178, rs121908179, rs138043021, rs587777825, rs587777826, rs121908180, rs121908181, rs281797258, rs74315396, rs74315397, rs587777827, rs74315399, rs137853154, rs281797259, rs587777828, rs1574339529, rs767221160, rs121908581, rs121908582, rs111033570, rs111033571, rs1588218453, rs121434632, rs113994189, rs113994192, rs28938468, rs113624356, rs121917777, rs587777829, rs587777830, rs113994195, rs113994196, rs113994178, rs113994190, rs113994191, rs137854887, rs587777836, rs587777837, rs148374859, rs387907136, rs193922710, rs193922711, rs431825171, rs386834044, rs386834046, rs386834047, rs386834050, rs201933838, rs386834051, rs386834149, rs386834152, rs386834153, rs62640570, rs386834159, rs199474722, rs137854907, rs151344630, rs179363897, rs62640580, rs62640582, rs62640574, rs62638179, rs281865187, rs281865188, rs62640578, rs515726134, rs515726135, rs515726136, rs587777546, rs587783009, rs587783010, rs587783016, rs587777846, rs587777847, rs672601379, rs727503781, rs727503818, rs727503853, rs786204444, rs786204701, rs768443448, rs770556842, rs786204705, rs786204575, rs786204573, rs786204671, rs756368560, rs749974697, rs786205636, rs786205855, rs370540673, rs794727006, rs797044632, rs794727070, rs766608755, rs370119681, rs758329611, rs770258677, rs376306240, rs797045946, rs797045948, rs797045706, rs863224529, rs863224530, rs762511626, rs863224534, rs863224782, rs761101213, rs863224522, rs869025207, rs869025208, rs869025204, rs869025205, rs869025209, rs869025211, rs869025210, rs869025206, rs863225187, rs771454167, rs575767207, rs756302731, rs780624853, rs863225182, rs863225189, rs863225183, rs727503855, rs863225186, rs758550675, rs768933093, rs756853299, rs878853352, rs371496675, rs878853360, rs377031435, rs878855095, rs200699377, rs746797123, rs886039875, rs751375244, rs775081992, rs886039799, rs886039801, rs886039798, rs758522600, rs886039805, rs886039802, rs886039800, rs886039797, rs780225183, rs886041464, rs760165634, rs886042359, rs886042360, rs886042729, rs201196733, rs773139166, rs886043841, rs886044106, rs886044668, rs770218590, rs752202089, rs1057515576, rs1057517193, rs764245266, rs1057516449, rs1057516507, rs1057517007, rs1057516451, rs376894444, rs1057516933, rs1057516502, rs1057516330, rs1057517332, rs1057516427, rs1057517143, rs746875134, rs1057516661, rs1057516371, rs1057516533, rs1057516901, rs775769424, rs773632109, rs1057516628, rs1057516754, rs375413604, rs1057516669, rs1057517031, rs773864735, rs759682922, rs1057517156, rs1057517206, rs1057516623, rs765561672, rs1057516998, rs1057516836, rs1057517184, rs1057516266, rs1057516753, rs774095109, rs1057516240, rs1057516701, rs1057516861, rs147030232, rs865870355, rs775043799, rs757641323, rs773386777, rs1057518822, rs1057519165, rs1057519027, rs775710800, rs1060499781, rs137962929, rs1060503690, rs1166022838, rs775950661, rs1060500996, rs367882912, rs1060503692, rs749017489, rs766087213, rs1064796315, rs1555202695, rs763762899, rs777464278, rs1555220638, rs1553794304, rs1578522416, rs780059308, rs1555202801, rs1553529427, rs1473611414, rs1553941312, rs752762669, rs898539189, rs1555202645, rs762668200, rs756632517, rs965522059, rs1555049194, rs1302879683, rs1555212271, rs1555220625, rs200818935, rs1553930514, rs1381368546, rs747388658, rs759376012, rs766670248, rs1555534964, rs1555202697, rs1286714661, rs1272411609, rs1555202584, rs567573386, rs1452465499, rs747685252, rs1555523398, rs1555213204, rs1555202538, rs1555197766, rs1555202806, rs1555801973, rs1460517643, rs1555047786, rs1555802009, rs1221499782, rs771266705, rs781174906, rs1170451277, rs1555225566, rs772757329, rs1553933472, rs991365297, rs1269565757, rs1555047409, rs200116631, rs776645403, rs757609119, rs770891152, rs751361090, rs753338844, rs1397714772, rs769588983, rs1553941255, rs1553941258, rs1553941279, rs1553941369, rs1195341481, rs1284876635, rs1553941540, rs1444062882, rs756061536, rs1173504533, rs1553941391, rs766741204, rs1553941433, rs745448288, rs770872200, rs1553941304, rs1553941404, rs1553941580, rs751753112, rs1555046748, rs771517209, rs748523268, rs1555050394, rs1014835928, rs1555049933, rs1182864166, rs1313590454, rs1555046611, rs1555049893, rs1555050268, rs1555050404, rs1555202546, rs1555202562, rs769028262, rs1389599028, rs1555202654, rs1555202731, rs1306821707, rs1353098253, rs183771956, rs1555202572, rs1555202583, rs759185809, rs1555202614, rs1555202636, rs758732081, rs1555202740, rs1310735399, rs1555202599, rs1555202642, rs1555202681, rs1278460471, rs1555202607, rs760642305, rs753604828, rs1555202656, rs1555202657, rs1156913215, rs574032499, rs1555202698, rs1555202737, rs760693838, rs202228478, rs1555520256, rs1555521379, rs777234811, rs1555522893, rs1273181642, rs1367927635, rs1555524593, rs1166717771, rs745951028, rs201063733, rs778090540, rs1555522000, rs544773389, rs773862084, rs1555520142, rs1555520220, rs762047808, rs1555521501, rs1555522252, rs764164384, rs1047075022, rs779690256, rs773417074, rs1555523964, rs750506474, rs1488635637, rs1555599412, rs1555521489, rs878962682, rs746171104, rs1555523584, rs375170572, rs1477098739, rs1559122157, rs1565289799, rs1565809409, rs1054138918, rs1466289570, rs1800908907, rs746478265, rs1563049863, rs1560638613, rs1564218190, rs1565809597, rs772170760, rs1565809867, rs750258633, rs1272140892, rs1559121920, rs1339432710, rs138011813, rs1562686929, rs1562917450, rs1565287512, rs1160669210, rs1486200900, rs1565291081, rs1340165752, rs1565809995, rs781421232, rs1565810301, rs1465437164, rs1567412639, rs1567427651, rs767373822, rs1568662687, rs1306231185, rs1568666460, rs780659194, rs1569077441, rs753884599, rs1559126736, rs1226386838, rs1472488128, rs1565835538, rs1565286223, rs763299856, rs1565286202, rs1390963789, rs1560658189, rs772917364, rs1565287921, rs1565809478, rs1567576202, rs1578489760, rs1470030897, rs1229015450, rs767481770, rs1356713858, rs1368647604, rs770084716, rs1559122277, rs561598805, rs1592726020, rs776004321, rs762276925, rs777420525, rs1578491070, rs1578491135, rs745656125, rs1294402003, rs587783017, rs778030031, rs754728136, rs749331348, rs1339975972, rs1468942944, rs760415289, rs1290241933, rs372822977, rs1597016660, rs1578537379, rs1587357327, rs751922029, rs775928735, rs768385647, rs1326810030, rs200113494, rs747266069, rs1490351829, rs1590772920, rs1592491950, rs1039146791, rs1597012997, rs1578577361, rs375548374, rs763473957, rs767822498, rs1578564877, rs1590762360, rs1592784618, rs1595935759, rs2037751886, rs1856758582, rs1951757988, rs1951767864, rs2065331681, rs1592492255, rs45502896, rs745497072, rs1221464366, rs773622064, rs2037752645, rs1354476372, rs772544112, rs1683644662, rs1394015094, rs767005321, rs398124253, rs35904234, rs778850233, rs138744839, rs778431173, rs1951758601, rs1951767589, rs553291328, rs2033254449, rs781310385, rs1364945778, rs761907569, rs1033594764, rs1186821575, rs1199538371, rs1363846772, rs777218224, rs903778224, rs1726566546, rs2039659434, rs761969357, rs1419924139, rs1363498219, rs762782183, rs974173261, rs1560708847, rs1856790811, rs2033937635, rs748471942, rs762633090, rs774490795, rs2065896039, rs759131391, rs1560664459, rs1856202628, rs1856699646, rs752197734, rs1295000119, rs2034232539, rs750073051, rs763559949
Diastrophic dysplasia	Diastrophic dysplasia	rs386833498, rs786200881, rs104893915, rs104893919, rs104893920, rs104893916, rs104893921, rs386833492, rs104893924, rs121908078, rs386833493, rs386833494, rs386833495, rs386833496, rs386833497, rs386833499, rs386833500, rs386833501, rs386833502, rs386833503, rs386833505, rs386833506, rs386833507, rs200963884, rs386833508, rs386833509, rs121908077, rs1057517523, rs1057517496, rs1057517462, rs1057517504, rs763198695, rs1057517483, rs1057517461, rs1057517524, rs1057517514, rs1057517526, rs1057517495, rs1057517532, rs1057517471, rs1057517502, rs1057517511, rs1057517482, rs1057517530, rs1057517474, rs762137330, rs1057517513
Keratosis follicularis	Keratosis Follicularis	rs28929478, rs121912731, rs1592839705, rs121912732, rs121912734, rs2137673961, rs1566240208, rs121912738, rs1592864859
Polydactyly	Polydactyly	rs1583729398, rs121917709, rs1583734240, rs121917714, rs397507422, rs398122899, rs587776959, rs386833752, rs1057518698, rs1060499558, rs755938967, rs1375768446, rs1309855392, rs1565601979, rs748321474, rs368652620, rs1562587032, rs760694987
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764

Associations from Text Mining
Disease Name	Relationship Type	References
Ciliopathies	Associate	27894351