Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27090
Gene name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Gene symbol	ST6GALNAC4
Synonyms (NCBI Gene)	IVSIAT3-CSIAT3CSIAT7-DSIAT7DST6GALNACIVST6GalNAc
Chromosome	9
Chromosome location	9q34.11
Summary	The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows re

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Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023399	hsa-miR-122-5p	Microarray	17612493
MIRT1393768	hsa-miR-3175	CLIP-seq
MIRT1393769	hsa-miR-4462	CLIP-seq
MIRT1393770	hsa-miR-4723-5p	CLIP-seq
MIRT2118196	hsa-miR-1275	CLIP-seq
MIRT2118197	hsa-miR-1322	CLIP-seq
MIRT2118198	hsa-miR-138	CLIP-seq
MIRT2118199	hsa-miR-1915	CLIP-seq
MIRT2118200	hsa-miR-219-1-3p	CLIP-seq
MIRT2118201	hsa-miR-3974	CLIP-seq
MIRT2118202	hsa-miR-4259	CLIP-seq
MIRT2118203	hsa-miR-4299	CLIP-seq
MIRT2118204	hsa-miR-4323	CLIP-seq
MIRT2118205	hsa-miR-433	CLIP-seq
MIRT2118206	hsa-miR-4457	CLIP-seq
MIRT2118207	hsa-miR-4488	CLIP-seq
MIRT2118208	hsa-miR-4529-5p	CLIP-seq
MIRT2118209	hsa-miR-4665-5p	CLIP-seq
MIRT2118210	hsa-miR-4690-3p	CLIP-seq
MIRT2118211	hsa-miR-4697-5p	CLIP-seq
MIRT2118212	hsa-miR-4710	CLIP-seq
MIRT2118213	hsa-miR-4717-5p	CLIP-seq
MIRT2118214	hsa-miR-4753-5p	CLIP-seq
MIRT2118215	hsa-miR-4792	CLIP-seq
MIRT2118216	hsa-miR-571	CLIP-seq
MIRT2118217	hsa-miR-624	CLIP-seq
MIRT2634074	hsa-miR-105	CLIP-seq
MIRT2634075	hsa-miR-1225-3p	CLIP-seq
MIRT2634076	hsa-miR-1233	CLIP-seq
MIRT2634077	hsa-miR-1266	CLIP-seq
MIRT2118196	hsa-miR-1275	CLIP-seq
MIRT2118197	hsa-miR-1322	CLIP-seq
MIRT2118198	hsa-miR-138	CLIP-seq
MIRT2118199	hsa-miR-1915	CLIP-seq
MIRT2634078	hsa-miR-197	CLIP-seq
MIRT2118200	hsa-miR-219-1-3p	CLIP-seq
MIRT2634079	hsa-miR-3127-3p	CLIP-seq
MIRT2634080	hsa-miR-3145-5p	CLIP-seq
MIRT2634081	hsa-miR-3155	CLIP-seq
MIRT2634082	hsa-miR-3155b	CLIP-seq
MIRT2634083	hsa-miR-342-5p	CLIP-seq
MIRT2634084	hsa-miR-3661	CLIP-seq
MIRT2634085	hsa-miR-3689d	CLIP-seq
MIRT2634086	hsa-miR-3922-5p	CLIP-seq
MIRT2634087	hsa-miR-3943	CLIP-seq
MIRT2118201	hsa-miR-3974	CLIP-seq
MIRT2634088	hsa-miR-412	CLIP-seq
MIRT2634089	hsa-miR-4254	CLIP-seq
MIRT2118202	hsa-miR-4259	CLIP-seq
MIRT2634090	hsa-miR-4270	CLIP-seq
MIRT2118203	hsa-miR-4299	CLIP-seq
MIRT2118204	hsa-miR-4323	CLIP-seq
MIRT2118205	hsa-miR-433	CLIP-seq
MIRT2634091	hsa-miR-4441	CLIP-seq
MIRT2118206	hsa-miR-4457	CLIP-seq
MIRT2118207	hsa-miR-4488	CLIP-seq
MIRT2634092	hsa-miR-4518	CLIP-seq
MIRT2118208	hsa-miR-4529-5p	CLIP-seq
MIRT2634093	hsa-miR-4651	CLIP-seq
MIRT2634094	hsa-miR-4664-5p	CLIP-seq
MIRT2118209	hsa-miR-4665-5p	CLIP-seq
MIRT2118210	hsa-miR-4690-3p	CLIP-seq
MIRT2118211	hsa-miR-4697-5p	CLIP-seq
MIRT2634095	hsa-miR-4704-3p	CLIP-seq
MIRT2634096	hsa-miR-4707-5p	CLIP-seq
MIRT2118212	hsa-miR-4710	CLIP-seq
MIRT2118213	hsa-miR-4717-5p	CLIP-seq
MIRT2118214	hsa-miR-4753-5p	CLIP-seq
MIRT2118215	hsa-miR-4792	CLIP-seq
MIRT2634097	hsa-miR-484	CLIP-seq
MIRT2634098	hsa-miR-510	CLIP-seq
MIRT2634099	hsa-miR-512-5p	CLIP-seq
MIRT2118216	hsa-miR-571	CLIP-seq
MIRT2634100	hsa-miR-608	CLIP-seq
MIRT2634101	hsa-miR-619	CLIP-seq
MIRT2118217	hsa-miR-624	CLIP-seq
MIRT2634102	hsa-miR-631	CLIP-seq
MIRT2634074	hsa-miR-105	CLIP-seq
MIRT2634075	hsa-miR-1225-3p	CLIP-seq
MIRT2634076	hsa-miR-1233	CLIP-seq
MIRT2692116	hsa-miR-1253	CLIP-seq
MIRT2634077	hsa-miR-1266	CLIP-seq
MIRT2118196	hsa-miR-1275	CLIP-seq
MIRT2692117	hsa-miR-1307	CLIP-seq
MIRT2118197	hsa-miR-1322	CLIP-seq
MIRT2118198	hsa-miR-138	CLIP-seq
MIRT2692118	hsa-miR-1913	CLIP-seq
MIRT2118199	hsa-miR-1915	CLIP-seq
MIRT2634078	hsa-miR-197	CLIP-seq
MIRT2118200	hsa-miR-219-1-3p	CLIP-seq
MIRT2634079	hsa-miR-3127-3p	CLIP-seq
MIRT2692119	hsa-miR-3141	CLIP-seq
MIRT2634080	hsa-miR-3145-5p	CLIP-seq
MIRT2634081	hsa-miR-3155	CLIP-seq
MIRT2634082	hsa-miR-3155b	CLIP-seq
MIRT2692120	hsa-miR-3189-5p	CLIP-seq
MIRT2692121	hsa-miR-3194-5p	CLIP-seq
MIRT2692122	hsa-miR-324-3p	CLIP-seq
MIRT2634083	hsa-miR-342-5p	CLIP-seq
MIRT2692123	hsa-miR-3615	CLIP-seq
MIRT2634084	hsa-miR-3661	CLIP-seq
MIRT2692124	hsa-miR-3688-5p	CLIP-seq
MIRT2634085	hsa-miR-3689d	CLIP-seq
MIRT2634086	hsa-miR-3922-5p	CLIP-seq
MIRT2634087	hsa-miR-3943	CLIP-seq
MIRT2118201	hsa-miR-3974	CLIP-seq
MIRT2634088	hsa-miR-412	CLIP-seq
MIRT2692125	hsa-miR-4251	CLIP-seq
MIRT2634089	hsa-miR-4254	CLIP-seq
MIRT2118202	hsa-miR-4259	CLIP-seq
MIRT2634090	hsa-miR-4270	CLIP-seq
MIRT2692126	hsa-miR-4293	CLIP-seq
MIRT2118203	hsa-miR-4299	CLIP-seq
MIRT2118204	hsa-miR-4323	CLIP-seq
MIRT2692127	hsa-miR-4324	CLIP-seq
MIRT2118205	hsa-miR-433	CLIP-seq
MIRT2634091	hsa-miR-4441	CLIP-seq
MIRT2118206	hsa-miR-4457	CLIP-seq
MIRT2118207	hsa-miR-4488	CLIP-seq
MIRT2634092	hsa-miR-4518	CLIP-seq
MIRT2118208	hsa-miR-4529-5p	CLIP-seq
MIRT2692128	hsa-miR-4638-5p	CLIP-seq
MIRT2634093	hsa-miR-4651	CLIP-seq
MIRT2634094	hsa-miR-4664-5p	CLIP-seq
MIRT2118209	hsa-miR-4665-5p	CLIP-seq
MIRT2692129	hsa-miR-4685-5p	CLIP-seq
MIRT2118210	hsa-miR-4690-3p	CLIP-seq
MIRT2118211	hsa-miR-4697-5p	CLIP-seq
MIRT2634095	hsa-miR-4704-3p	CLIP-seq
MIRT2634096	hsa-miR-4707-5p	CLIP-seq
MIRT2118212	hsa-miR-4710	CLIP-seq
MIRT2118213	hsa-miR-4717-5p	CLIP-seq
MIRT2118214	hsa-miR-4753-5p	CLIP-seq
MIRT2692130	hsa-miR-4758-3p	CLIP-seq
MIRT2118215	hsa-miR-4792	CLIP-seq
MIRT2634097	hsa-miR-484	CLIP-seq
MIRT2634098	hsa-miR-510	CLIP-seq
MIRT2634099	hsa-miR-512-5p	CLIP-seq
MIRT2118216	hsa-miR-571	CLIP-seq
MIRT2692131	hsa-miR-595	CLIP-seq
MIRT2634100	hsa-miR-608	CLIP-seq
MIRT2634101	hsa-miR-619	CLIP-seq
MIRT2118217	hsa-miR-624	CLIP-seq
MIRT2634102	hsa-miR-631	CLIP-seq
MIRT2692132	hsa-miR-644	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006664	Process	Glycolipid metabolic process	IEA
GO:0006664	Process	Glycolipid metabolic process	TAS	10207017
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	TAS	10207017
GO:0009311	Process	Oligosaccharide metabolic process	IBA
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0047290	Function	Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	IEA
GO:0047290	Function	Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	TAS

MIM	HGNC	e!Ensembl
606378	17846	ENSG00000136840

Q9H4F1

Protein name

Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.7) (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (ST6GalNAcIV) (Sialyltransferase 3C) (SIAT3-C) (Sialyltran

Protein function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disial

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	56 → 296	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MKAPGRLVLIILCSVVFSAVYILLCCWAGLPLCLATCLDHHFPTGSRPTVPGPLHFSGYS
SVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRST
LRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGRTYRTLLQLTRMYPGLQ
VYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCR
EKSHPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR
TE

Sequence length

302

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series Metabolic pathways		Sialic acid metabolism Termination of O-glycan biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	37381011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	34970268	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	23567325	★★★★★ ★☆☆☆☆ Found in Text Mining only

ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4)