Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27074
Gene name	Lysosomal associated membrane protein 3
Gene symbol	LAMP3
Synonyms (NCBI Gene)	CD208DC LAMPDC-LAMPDCLAMPLAMPLAMP-3TSC403
Chromosome	3
Chromosome location	3q27.1
Summary	Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis e

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029868	hsa-miR-26b-5p	Microarray	19088304
MIRT702304	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702305	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT702303	hsa-miR-5692b	HITS-CLIP	23313552
MIRT702302	hsa-miR-5692c	HITS-CLIP	23313552
MIRT702301	hsa-miR-4796-5p	HITS-CLIP	23313552
MIRT702300	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT702299	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT702304	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702305	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT702303	hsa-miR-5692b	HITS-CLIP	23313552
MIRT702302	hsa-miR-5692c	HITS-CLIP	23313552
MIRT702301	hsa-miR-4796-5p	HITS-CLIP	23313552
MIRT702300	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT702299	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT1103647	hsa-miR-106a	CLIP-seq
MIRT1103648	hsa-miR-106b	CLIP-seq
MIRT1103649	hsa-miR-1273d	CLIP-seq
MIRT1103650	hsa-miR-142-5p	CLIP-seq
MIRT1103651	hsa-miR-17	CLIP-seq
MIRT1103652	hsa-miR-18a	CLIP-seq
MIRT1103653	hsa-miR-18b	CLIP-seq
MIRT1103654	hsa-miR-2053	CLIP-seq
MIRT1103655	hsa-miR-20a	CLIP-seq
MIRT1103656	hsa-miR-20b	CLIP-seq
MIRT1103657	hsa-miR-302a	CLIP-seq
MIRT1103658	hsa-miR-302b	CLIP-seq
MIRT1103659	hsa-miR-302c	CLIP-seq
MIRT1103660	hsa-miR-302d	CLIP-seq
MIRT1103661	hsa-miR-302e	CLIP-seq
MIRT1103662	hsa-miR-3128	CLIP-seq
MIRT1103663	hsa-miR-3176	CLIP-seq
MIRT1103664	hsa-miR-335	CLIP-seq
MIRT1103665	hsa-miR-339-5p	CLIP-seq
MIRT1103666	hsa-miR-34b	CLIP-seq
MIRT1103667	hsa-miR-3609	CLIP-seq
MIRT1103668	hsa-miR-3614-5p	CLIP-seq
MIRT1103669	hsa-miR-372	CLIP-seq
MIRT1103670	hsa-miR-373	CLIP-seq
MIRT1103671	hsa-miR-374a	CLIP-seq
MIRT1103672	hsa-miR-374b	CLIP-seq
MIRT1103673	hsa-miR-3922-3p	CLIP-seq
MIRT1103674	hsa-miR-3926	CLIP-seq
MIRT1103675	hsa-miR-4446-5p	CLIP-seq
MIRT1103676	hsa-miR-4522	CLIP-seq
MIRT1103677	hsa-miR-4659a-5p	CLIP-seq
MIRT1103678	hsa-miR-4659b-5p	CLIP-seq
MIRT1103679	hsa-miR-4720-5p	CLIP-seq
MIRT1103680	hsa-miR-4735-3p	CLIP-seq
MIRT1103681	hsa-miR-4755-5p	CLIP-seq
MIRT1103682	hsa-miR-4776-3p	CLIP-seq
MIRT1103683	hsa-miR-4792	CLIP-seq
MIRT1103684	hsa-miR-4796-3p	CLIP-seq
MIRT1103685	hsa-miR-4799-3p	CLIP-seq
MIRT1103686	hsa-miR-519d	CLIP-seq
MIRT1103687	hsa-miR-520a-3p	CLIP-seq
MIRT1103688	hsa-miR-520b	CLIP-seq
MIRT1103689	hsa-miR-520c-3p	CLIP-seq
MIRT1103690	hsa-miR-520d-3p	CLIP-seq
MIRT1103691	hsa-miR-520e	CLIP-seq
MIRT1103692	hsa-miR-520f	CLIP-seq
MIRT1103693	hsa-miR-548ah	CLIP-seq
MIRT1103694	hsa-miR-548s	CLIP-seq
MIRT1103695	hsa-miR-569	CLIP-seq
MIRT1103696	hsa-miR-577	CLIP-seq
MIRT1103697	hsa-miR-622	CLIP-seq
MIRT1103698	hsa-miR-658	CLIP-seq
MIRT1103699	hsa-miR-660	CLIP-seq
MIRT1103700	hsa-miR-670	CLIP-seq
MIRT1103701	hsa-miR-93	CLIP-seq
MIRT2028306	hsa-miR-1293	CLIP-seq
MIRT2028307	hsa-miR-142-3p	CLIP-seq
MIRT2028308	hsa-miR-3122	CLIP-seq
MIRT2028309	hsa-miR-3165	CLIP-seq
MIRT1103664	hsa-miR-335	CLIP-seq
MIRT2028310	hsa-miR-3622a-3p	CLIP-seq
MIRT2028311	hsa-miR-3622b-3p	CLIP-seq
MIRT2028312	hsa-miR-3689a-3p	CLIP-seq
MIRT2028313	hsa-miR-3689c	CLIP-seq
MIRT2028314	hsa-miR-3913-5p	CLIP-seq
MIRT2028315	hsa-miR-3929	CLIP-seq
MIRT2028316	hsa-miR-4419b	CLIP-seq
MIRT2028317	hsa-miR-4452	CLIP-seq
MIRT2028318	hsa-miR-4478	CLIP-seq
MIRT2028319	hsa-miR-4483	CLIP-seq
MIRT2028320	hsa-miR-4536	CLIP-seq
MIRT2028321	hsa-miR-4662a-5p	CLIP-seq
MIRT2028322	hsa-miR-4676-5p	CLIP-seq
MIRT2028323	hsa-miR-4728-5p	CLIP-seq
MIRT2028324	hsa-miR-4755-3p	CLIP-seq
MIRT2028325	hsa-miR-485-5p	CLIP-seq
MIRT2028326	hsa-miR-544b	CLIP-seq
MIRT2028327	hsa-miR-550a	CLIP-seq
MIRT2028328	hsa-miR-575	CLIP-seq
MIRT1103697	hsa-miR-622	CLIP-seq
MIRT2028329	hsa-miR-648	CLIP-seq
MIRT2028306	hsa-miR-1293	CLIP-seq
MIRT2028308	hsa-miR-3122	CLIP-seq
MIRT2259458	hsa-miR-3163	CLIP-seq
MIRT2028309	hsa-miR-3165	CLIP-seq
MIRT1103664	hsa-miR-335	CLIP-seq
MIRT2028310	hsa-miR-3622a-3p	CLIP-seq
MIRT2028311	hsa-miR-3622b-3p	CLIP-seq
MIRT2028312	hsa-miR-3689a-3p	CLIP-seq
MIRT2028313	hsa-miR-3689c	CLIP-seq
MIRT2028314	hsa-miR-3913-5p	CLIP-seq
MIRT2028315	hsa-miR-3929	CLIP-seq
MIRT2028316	hsa-miR-4419b	CLIP-seq
MIRT2028318	hsa-miR-4478	CLIP-seq
MIRT2028319	hsa-miR-4483	CLIP-seq
MIRT2259459	hsa-miR-4668-3p	CLIP-seq
MIRT2259460	hsa-miR-4722-5p	CLIP-seq
MIRT2028323	hsa-miR-4728-5p	CLIP-seq
MIRT2028325	hsa-miR-485-5p	CLIP-seq
MIRT2259461	hsa-miR-505	CLIP-seq
MIRT2028326	hsa-miR-544b	CLIP-seq
MIRT2028327	hsa-miR-550a	CLIP-seq
MIRT2028306	hsa-miR-1293	CLIP-seq
MIRT2390068	hsa-miR-24	CLIP-seq
MIRT2028308	hsa-miR-3122	CLIP-seq
MIRT2028312	hsa-miR-3689a-3p	CLIP-seq
MIRT2028313	hsa-miR-3689c	CLIP-seq
MIRT2028314	hsa-miR-3913-5p	CLIP-seq
MIRT2028315	hsa-miR-3929	CLIP-seq
MIRT2390069	hsa-miR-4284	CLIP-seq
MIRT2028316	hsa-miR-4419b	CLIP-seq
MIRT2028318	hsa-miR-4478	CLIP-seq
MIRT2028319	hsa-miR-4483	CLIP-seq
MIRT2028323	hsa-miR-4728-5p	CLIP-seq
MIRT2028325	hsa-miR-485-5p	CLIP-seq
MIRT2028306	hsa-miR-1293	CLIP-seq
MIRT2028308	hsa-miR-3122	CLIP-seq
MIRT2028309	hsa-miR-3165	CLIP-seq
MIRT1103664	hsa-miR-335	CLIP-seq
MIRT1103666	hsa-miR-34b	CLIP-seq
MIRT2559824	hsa-miR-3613-3p	CLIP-seq
MIRT1103668	hsa-miR-3614-5p	CLIP-seq
MIRT2028310	hsa-miR-3622a-3p	CLIP-seq
MIRT2028311	hsa-miR-3622b-3p	CLIP-seq
MIRT2028312	hsa-miR-3689a-3p	CLIP-seq
MIRT2028313	hsa-miR-3689c	CLIP-seq
MIRT2559825	hsa-miR-371-5p	CLIP-seq
MIRT2559826	hsa-miR-371b-5p	CLIP-seq
MIRT2028314	hsa-miR-3913-5p	CLIP-seq
MIRT2028315	hsa-miR-3929	CLIP-seq
MIRT2028316	hsa-miR-4419b	CLIP-seq
MIRT2028318	hsa-miR-4478	CLIP-seq
MIRT2028319	hsa-miR-4483	CLIP-seq
MIRT1103677	hsa-miR-4659a-5p	CLIP-seq
MIRT1103678	hsa-miR-4659b-5p	CLIP-seq
MIRT2259460	hsa-miR-4722-5p	CLIP-seq
MIRT2028323	hsa-miR-4728-5p	CLIP-seq
MIRT2559827	hsa-miR-4738-3p	CLIP-seq
MIRT2559828	hsa-miR-4768-3p	CLIP-seq
MIRT1103682	hsa-miR-4776-3p	CLIP-seq
MIRT2028325	hsa-miR-485-5p	CLIP-seq
MIRT2028326	hsa-miR-544b	CLIP-seq
MIRT1103698	hsa-miR-658	CLIP-seq
MIRT2028306	hsa-miR-1293	CLIP-seq
MIRT2028308	hsa-miR-3122	CLIP-seq
MIRT2028309	hsa-miR-3165	CLIP-seq
MIRT1103664	hsa-miR-335	CLIP-seq
MIRT2559824	hsa-miR-3613-3p	CLIP-seq
MIRT2028310	hsa-miR-3622a-3p	CLIP-seq
MIRT2028311	hsa-miR-3622b-3p	CLIP-seq
MIRT2028312	hsa-miR-3689a-3p	CLIP-seq
MIRT2028313	hsa-miR-3689c	CLIP-seq
MIRT2559825	hsa-miR-371-5p	CLIP-seq
MIRT2559826	hsa-miR-371b-5p	CLIP-seq
MIRT2028314	hsa-miR-3913-5p	CLIP-seq
MIRT2028315	hsa-miR-3929	CLIP-seq
MIRT2028316	hsa-miR-4419b	CLIP-seq
MIRT2028318	hsa-miR-4478	CLIP-seq
MIRT2028319	hsa-miR-4483	CLIP-seq
MIRT2028323	hsa-miR-4728-5p	CLIP-seq
MIRT2559827	hsa-miR-4738-3p	CLIP-seq
MIRT2028325	hsa-miR-485-5p	CLIP-seq
MIRT2028326	hsa-miR-544b	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS	9721848
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	21810281
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	21810281
GO:0009986	Component	Cell surface	IEA
GO:0010506	Process	Regulation of autophagy	IMP	25681212
GO:0010628	Process	Positive regulation of gene expression	IMP	23651994
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031982	Component	Vesicle	IDA	25681212
GO:0035455	Process	Response to interferon-alpha	IMP	23651994
GO:0046718	Process	Symbiont entry into host cell	IMP	21810281
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	25681212
GO:0072594	Process	Establishment of protein localization to organelle	IBA
GO:0097233	Component	Alveolar lamellar body membrane	ISS
GO:1901799	Process	Negative regulation of proteasomal protein catabolic process	IMP	25681212
GO:1903900	Process	Regulation of viral life cycle	IMP	21810281

MIM	HGNC	e!Ensembl
605883	14582	ENSG00000078081

Q9UQV4

Protein name

Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)

Protein function

Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the ly

PDB

4AKM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01299	Lamp	223 → 366	Lysosome-associated membrane glycoprotein (Lamp)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lun

Sequence

MPRQLSAAAALFASLAVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAP
HQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTLVTTQATPNNSHTAPPV
TEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKST
TGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKA
EMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQGGFVNLTFTKDEES
YYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQL
QAFDFEDDHFGNVDECSSDYTIVLPVIGAIVVGLCLMGMGVYKIRLRCQSSGYQRI

Sequence length

416

Interactions

View interactions

	KEGG
	Lysosome

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
See cases	Uncertain significance	rs770560672	RCV003388301

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Coronary Syndrome	Associate	34753383
Adenocarcinoma of Lung	Associate	34580602
Arthritis Rheumatoid	Associate	18292234
Bipolar Disorder	Associate	27759212
Breast Neoplasms	Associate	20678512, 23294542, 37747033
Breast Neoplasms	Stimulate	28607528
Buschke Lowenstein Tumor	Associate	23569139
Carcinoma Intraductal Noninfiltrating	Associate	37373062
Clinical Deterioration	Stimulate	25997515
Colorectal Neoplasms	Associate	11485903, 25362357
Colorectal Neoplasms	Inhibit	35924107
COVID 19	Associate	33414384, 39334929
Dermatitis Atopic	Associate	32035984
Endometrial Neoplasms	Associate	37276865, 38217544
Endometriosis	Associate	35992117
Esophageal Squamous Cell Carcinoma	Associate	26263981, 36434949, 36921563
Gastrointestinal Neoplasms	Associate	25362357, 28607528
Glomerulonephritis	Associate	18368027
Hereditary Breast and Ovarian Cancer Syndrome	Associate	38217544
Hermansky Pudlak syndrome 2	Inhibit	27207797
Hypoxia	Associate	23294542, 37878884
Hypoxia	Stimulate	26191259, 26263981, 28849219
Inflammation	Associate	12186835, 31842954, 34359833, 34580602
Inflammation	Stimulate	18671865, 25997515
Influenza Human	Associate	25345603, 34367124
Leukemia Lymphocytic Chronic B Cell	Associate	19074592
Lipoma of the Conjunctiva	Associate	34349764
Necrosis	Stimulate	37373062
Neoplasm Metastasis	Associate	23294542, 28849219
Neoplasms	Associate	23294542, 25362357, 26191259, 28607528, 31675496, 32605588, 36305631, 37740656, 38033043
Neoplasms	Stimulate	26263981, 37373062, 38169917
Non Muscle Invasive Bladder Neoplasms	Associate	37082269
Osteoporosis	Associate	39778696
Osteosarcoma	Stimulate	28849219
Osteosarcoma	Associate	30008754
Ovarian Neoplasms	Associate	28349821
Parkinson Disease	Associate	21812969, 24312176
Parkinson Disease	Inhibit	22786590
Pre Eclampsia	Stimulate	37878884
REM Sleep Behavior Disorder	Associate	33397775
Sarcoma Kaposi	Associate	36377873
Sjogren's Syndrome	Associate	32939030, 34349764
Squamous Cell Carcinoma of Head and Neck	Associate	26191259, 28607528, 37740656
Stomach Neoplasms	Associate	25362357, 37215115
Triple Negative Breast Neoplasms	Stimulate	34224371
Triple Negative Breast Neoplasms	Associate	37512096
Urethral Neoplasms	Associate	36939254
Uterine Cervical Neoplasms	Associate	28607528
Wiskott Aldrich Syndrome	Stimulate	11745360

LAMP3 (lysosomal associated membrane protein 3)