Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27071
Gene name Gene Name - the full gene name approved by the HGNC.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DAPP1
Synonyms (NCBI Gene) Gene synonyms aliases	BAM32
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q23

Show/Hide all(124)

miRTarBase ID	miRNA	Experiments
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923203	hsa-miR-129-5p	CLIP-seq
MIRT923204	hsa-miR-1302	CLIP-seq
MIRT923205	hsa-miR-184	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923207	hsa-miR-2052	CLIP-seq
MIRT923208	hsa-miR-3122	CLIP-seq
MIRT923209	hsa-miR-3149	CLIP-seq
MIRT923210	hsa-miR-3182	CLIP-seq
MIRT923211	hsa-miR-345	CLIP-seq
MIRT923212	hsa-miR-3664-5p	CLIP-seq
MIRT923213	hsa-miR-3913-5p	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923215	hsa-miR-4294	CLIP-seq
MIRT923216	hsa-miR-4298	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923219	hsa-miR-4522	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT923221	hsa-miR-4652-3p	CLIP-seq
MIRT923222	hsa-miR-4715-3p	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923223	hsa-miR-4735-5p	CLIP-seq
MIRT923224	hsa-miR-4763-5p	CLIP-seq
MIRT923225	hsa-miR-4775	CLIP-seq
MIRT740094	hsa-miR-492	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT740092	hsa-miR-513a-3p	CLIP-seq
MIRT923228	hsa-miR-520d-5p	CLIP-seq
MIRT923229	hsa-miR-524-5p	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923231	hsa-miR-550b	CLIP-seq
MIRT923232	hsa-miR-566	CLIP-seq
MIRT923233	hsa-miR-590-3p	CLIP-seq
MIRT1547860	hsa-miR-4420	CLIP-seq
MIRT1547861	hsa-miR-4772-3p	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923203	hsa-miR-129-5p	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT1973543	hsa-miR-4307	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT1547860	hsa-miR-4420	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT1547861	hsa-miR-4772-3p	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT1973544	hsa-miR-659	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT1547860	hsa-miR-4420	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT1547861	hsa-miR-4772-3p	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923232	hsa-miR-566	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923209	hsa-miR-3149	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT923222	hsa-miR-4715-3p	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923223	hsa-miR-4735-5p	CLIP-seq
MIRT923224	hsa-miR-4763-5p	CLIP-seq
MIRT923225	hsa-miR-4775	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923232	hsa-miR-566	CLIP-seq
MIRT923233	hsa-miR-590-3p	CLIP-seq
MIRT923202	hsa-miR-1200	CLIP-seq
MIRT923206	hsa-miR-1976	CLIP-seq
MIRT923209	hsa-miR-3149	CLIP-seq
MIRT923214	hsa-miR-4279	CLIP-seq
MIRT923217	hsa-miR-4324	CLIP-seq
MIRT923218	hsa-miR-4438	CLIP-seq
MIRT923220	hsa-miR-4532	CLIP-seq
MIRT923222	hsa-miR-4715-3p	CLIP-seq
MIRT740093	hsa-miR-4722-3p	CLIP-seq
MIRT923223	hsa-miR-4735-5p	CLIP-seq
MIRT923224	hsa-miR-4763-5p	CLIP-seq
MIRT923225	hsa-miR-4775	CLIP-seq
MIRT923226	hsa-miR-498	CLIP-seq
MIRT923227	hsa-miR-5095	CLIP-seq
MIRT923230	hsa-miR-544b	CLIP-seq
MIRT923232	hsa-miR-566	CLIP-seq
MIRT923233	hsa-miR-590-3p	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554, 32296183, 32814053
GO:0005543	Function	Phospholipid binding	NAS	10432293
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	11001876
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	17823121
GO:0005886	Component	Plasma membrane	TAS
GO:0006470	Process	Protein dephosphorylation	NAS	10432293
GO:0007165	Process	Signal transduction	TAS	10432293
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	11001876, 17823121

MIM	HGNC	e!Ensembl
605768	16500	ENSG00000070190

Protein

UniProt ID

Q9UN19

Protein name

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)

Protein function

May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

PDB

1FAO , 1FB8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	35 → 109	SH2 domain	Domain
PF00169	PH	165 → 259	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269|PubMed:10432293}.

Sequence

MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLL
RDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETG
TLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT
WKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLC
AKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK

Sequence length

280

Interactions

View interactions

	KEGG		Reactome
	B cell receptor signaling pathway		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	18784066

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Gout	Gout			GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Autism Spectrum Disorder	Associate	23275889
Communicable Diseases	Associate	38310908
COVID 19	Associate	38310908
Neoplasms	Associate	34827689

DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1)