Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	27067
Gene name	Staufen double-stranded RNA binding protein 2
Gene symbol	STAU2
Synonyms (NCBI Gene)	39K239K3
Chromosome	8
Chromosome location	8q21.11
Summary	Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023297	hsa-miR-122-5p	Microarray	17612493
MIRT1396168	hsa-miR-1537	CLIP-seq
MIRT1396169	hsa-miR-203	CLIP-seq
MIRT1396170	hsa-miR-3123	CLIP-seq
MIRT1396171	hsa-miR-4481	CLIP-seq
MIRT1396172	hsa-miR-4712-3p	CLIP-seq
MIRT1396173	hsa-miR-4745-5p	CLIP-seq
MIRT1396174	hsa-miR-4758-5p	CLIP-seq
MIRT1396175	hsa-miR-1245b-3p	CLIP-seq
MIRT1396176	hsa-miR-1253	CLIP-seq
MIRT1396177	hsa-miR-1305	CLIP-seq
MIRT1396178	hsa-miR-23a	CLIP-seq
MIRT1396179	hsa-miR-23b	CLIP-seq
MIRT1396180	hsa-miR-23c	CLIP-seq
MIRT1396181	hsa-miR-3171	CLIP-seq
MIRT1396182	hsa-miR-3185	CLIP-seq
MIRT1396183	hsa-miR-3190	CLIP-seq
MIRT1396184	hsa-miR-3200-5p	CLIP-seq
MIRT1396185	hsa-miR-329	CLIP-seq
MIRT1396186	hsa-miR-362-3p	CLIP-seq
MIRT1396187	hsa-miR-3915	CLIP-seq
MIRT1396188	hsa-miR-3922-5p	CLIP-seq
MIRT1396189	hsa-miR-3928	CLIP-seq
MIRT1396190	hsa-miR-3941	CLIP-seq
MIRT1396191	hsa-miR-3942-5p	CLIP-seq
MIRT1396192	hsa-miR-4263	CLIP-seq
MIRT1396193	hsa-miR-4312	CLIP-seq
MIRT1396194	hsa-miR-4426	CLIP-seq
MIRT1396195	hsa-miR-4434	CLIP-seq
MIRT1396196	hsa-miR-4477b	CLIP-seq
MIRT1396197	hsa-miR-4514	CLIP-seq
MIRT1396198	hsa-miR-4516	CLIP-seq
MIRT1396199	hsa-miR-4531	CLIP-seq
MIRT1396200	hsa-miR-4639-3p	CLIP-seq
MIRT1396201	hsa-miR-4647	CLIP-seq
MIRT1396202	hsa-miR-4649-3p	CLIP-seq
MIRT1396203	hsa-miR-4662b	CLIP-seq
MIRT1396204	hsa-miR-4684-5p	CLIP-seq
MIRT1396205	hsa-miR-4692	CLIP-seq
MIRT1396206	hsa-miR-4694-3p	CLIP-seq
MIRT1396207	hsa-miR-4703-5p	CLIP-seq
MIRT1396208	hsa-miR-4731-3p	CLIP-seq
MIRT1396209	hsa-miR-4735-5p	CLIP-seq
MIRT1396210	hsa-miR-4752	CLIP-seq
MIRT1396211	hsa-miR-4760-3p	CLIP-seq
MIRT1396212	hsa-miR-4793-5p	CLIP-seq
MIRT1396213	hsa-miR-4801	CLIP-seq
MIRT1396214	hsa-miR-498	CLIP-seq
MIRT1396215	hsa-miR-548u	CLIP-seq
MIRT1396216	hsa-miR-576-5p	CLIP-seq
MIRT1396217	hsa-miR-587	CLIP-seq
MIRT1396218	hsa-miR-603	CLIP-seq
MIRT1396219	hsa-miR-7	CLIP-seq
MIRT1396220	hsa-miR-1178	CLIP-seq
MIRT1396221	hsa-miR-1205	CLIP-seq
MIRT1396222	hsa-miR-140-5p	CLIP-seq
MIRT1396223	hsa-miR-196a	CLIP-seq
MIRT1396224	hsa-miR-196b	CLIP-seq
MIRT1396225	hsa-miR-22	CLIP-seq
MIRT1396184	hsa-miR-3200-5p	CLIP-seq
MIRT1396185	hsa-miR-329	CLIP-seq
MIRT1396226	hsa-miR-3545-5p	CLIP-seq
MIRT1396186	hsa-miR-362-3p	CLIP-seq
MIRT1396227	hsa-miR-3665	CLIP-seq
MIRT1396187	hsa-miR-3915	CLIP-seq
MIRT1396189	hsa-miR-3928	CLIP-seq
MIRT1396190	hsa-miR-3941	CLIP-seq
MIRT1396191	hsa-miR-3942-5p	CLIP-seq
MIRT1396228	hsa-miR-4460	CLIP-seq
MIRT1396200	hsa-miR-4639-3p	CLIP-seq
MIRT1396202	hsa-miR-4649-3p	CLIP-seq
MIRT1396204	hsa-miR-4684-5p	CLIP-seq
MIRT1396207	hsa-miR-4703-5p	CLIP-seq
MIRT1396208	hsa-miR-4731-3p	CLIP-seq
MIRT1396229	hsa-miR-4797-5p	CLIP-seq
MIRT1396213	hsa-miR-4801	CLIP-seq
MIRT1396218	hsa-miR-603	CLIP-seq
MIRT1396230	hsa-miR-657	CLIP-seq
MIRT1396231	hsa-miR-767-3p	CLIP-seq
MIRT1396232	hsa-miR-3154	CLIP-seq
MIRT1396233	hsa-miR-3616-5p	CLIP-seq
MIRT1396234	hsa-miR-3647-5p	CLIP-seq
MIRT1396235	hsa-miR-4795-5p	CLIP-seq
MIRT1396236	hsa-miR-573	CLIP-seq
MIRT2118810	hsa-miR-380	CLIP-seq
MIRT2118811	hsa-miR-4495	CLIP-seq
MIRT2118812	hsa-miR-4775	CLIP-seq
MIRT2118813	hsa-miR-548c-3p	CLIP-seq
MIRT2118814	hsa-miR-582-5p	CLIP-seq
MIRT2118815	hsa-miR-664	CLIP-seq
MIRT2395306	hsa-miR-130a	CLIP-seq
MIRT2395307	hsa-miR-130b	CLIP-seq
MIRT2395308	hsa-miR-142-3p	CLIP-seq
MIRT2395309	hsa-miR-153	CLIP-seq
MIRT2395310	hsa-miR-301a	CLIP-seq
MIRT2395311	hsa-miR-301b	CLIP-seq
MIRT2395312	hsa-miR-3666	CLIP-seq
MIRT2395313	hsa-miR-3674	CLIP-seq
MIRT2395314	hsa-miR-4295	CLIP-seq
MIRT2395315	hsa-miR-448	CLIP-seq
MIRT2395316	hsa-miR-454	CLIP-seq
MIRT2395317	hsa-miR-4671-3p	CLIP-seq
MIRT2460649	hsa-miR-223	CLIP-seq
MIRT1396227	hsa-miR-3665	CLIP-seq
MIRT2460650	hsa-miR-4736	CLIP-seq
MIRT2118812	hsa-miR-4775	CLIP-seq
MIRT2460651	hsa-miR-764	CLIP-seq
MIRT2634932	hsa-miR-141	CLIP-seq
MIRT2634933	hsa-miR-200a	CLIP-seq
MIRT2634934	hsa-miR-204	CLIP-seq
MIRT2634935	hsa-miR-211	CLIP-seq
MIRT1396178	hsa-miR-23a	CLIP-seq
MIRT1396179	hsa-miR-23b	CLIP-seq
MIRT1396180	hsa-miR-23c	CLIP-seq
MIRT2634936	hsa-miR-3143	CLIP-seq
MIRT2634937	hsa-miR-3692	CLIP-seq
MIRT2634938	hsa-miR-383	CLIP-seq
MIRT2634939	hsa-miR-3925-3p	CLIP-seq
MIRT2634940	hsa-miR-4424	CLIP-seq
MIRT2634941	hsa-miR-4444	CLIP-seq
MIRT2634942	hsa-miR-4446-5p	CLIP-seq
MIRT2634943	hsa-miR-4503	CLIP-seq
MIRT2634944	hsa-miR-4522	CLIP-seq
MIRT2634945	hsa-miR-4690-5p	CLIP-seq
MIRT2634946	hsa-miR-4695-3p	CLIP-seq
MIRT2634947	hsa-miR-4712-5p	CLIP-seq
MIRT2634948	hsa-miR-4738-3p	CLIP-seq
MIRT2634949	hsa-miR-4755-5p	CLIP-seq
MIRT2634950	hsa-miR-516a-5p	CLIP-seq
MIRT2634951	hsa-miR-543	CLIP-seq
MIRT2634952	hsa-miR-544	CLIP-seq
MIRT2634953	hsa-miR-579	CLIP-seq
MIRT2634954	hsa-miR-606	CLIP-seq
MIRT2634955	hsa-miR-623	CLIP-seq
MIRT2634956	hsa-miR-645	CLIP-seq
MIRT2634957	hsa-miR-659	CLIP-seq
MIRT2634958	hsa-miR-770-5p	CLIP-seq
MIRT2634932	hsa-miR-141	CLIP-seq
MIRT2634933	hsa-miR-200a	CLIP-seq
MIRT2634938	hsa-miR-383	CLIP-seq
MIRT2634939	hsa-miR-3925-3p	CLIP-seq
MIRT2634940	hsa-miR-4424	CLIP-seq
MIRT2634941	hsa-miR-4444	CLIP-seq
MIRT2634943	hsa-miR-4503	CLIP-seq
MIRT2634945	hsa-miR-4690-5p	CLIP-seq
MIRT2634946	hsa-miR-4695-3p	CLIP-seq
MIRT2634947	hsa-miR-4712-5p	CLIP-seq
MIRT2634950	hsa-miR-516a-5p	CLIP-seq
MIRT2634952	hsa-miR-544	CLIP-seq
MIRT2634956	hsa-miR-645	CLIP-seq
MIRT2634958	hsa-miR-770-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0003725	Function	Double-stranded RNA binding	TAS	10585778
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	21903422, 23125361, 32707033, 34159380
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0007281	Process	Germ cell development	IBA
GO:0008298	Process	Intracellular mRNA localization	IBA
GO:0010494	Component	Cytoplasmic stress granule	IBA
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019894	Function	Kinesin binding	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0034599	Process	Cellular response to oxidative stress	IEA
GO:0035418	Process	Protein localization to synapse	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0043022	Function	Ribosome binding	IEA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043198	Component	Dendritic shaft	IEA
GO:0048592	Process	Eye morphogenesis	IEA
GO:0051019	Function	Mitogen-activated protein kinase binding	IEA
GO:0051489	Process	Regulation of filopodium assembly	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098964	Process	Anterograde dendritic transport of messenger ribonucleoprotein complex	IBA
GO:0098964	Process	Anterograde dendritic transport of messenger ribonucleoprotein complex	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900454	Process	Positive regulation of long-term synaptic depression	IEA

MIM	HGNC	e!Ensembl
605920	11371	ENSG00000040341

Q9NUL3

Protein name

Double-stranded RNA-binding protein Staufen homolog 2

Protein function

RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for n

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00035	dsrm	9 → 72	Double-stranded RNA binding motif	Domain
PF00035	dsrm	127 → 179	Double-stranded RNA binding motif	Domain
PF00035	dsrm	208 → 272	Double-stranded RNA binding motif	Domain
PF00035	dsrm	308 → 373	Double-stranded RNA binding motif	Domain
PF16482	Staufen_C	455 → 523	Staufen C-terminal domain	Domain

Sequence

MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKK
AQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKP
FPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQ
NEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFV
TRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGP
EYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKI
AKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVY
QEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAI
GLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMNIEKGSLEK
QAKHLREKADNNQAPPGSIAQDCKKSNSAV

Sequence length

570

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATITIS B VIRUS INFECTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEPROSY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Stimulate	33441653	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	26843428	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure Diastolic	Associate	28105587	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	33441653, 35942760	★★★★★ ★☆☆☆☆ Found in Text Mining only

STAU2 (staufen double-stranded RNA binding protein 2)