STAU2 (staufen double-stranded RNA binding protein 2)

Gene

• Entrez ID: 27067
• Gene name: Staufen double-stranded RNA binding protein 2
• Gene symbol: STAU2
• Synonyms (NCBI Gene): 39K2, 39K3
• Chromosome: 8
• Chromosome location: 8q21.11
• Summary: Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023297	hsa-miR-122-5p	Microarray	17612493
MIRT1396168	hsa-miR-1537	CLIP-seq
MIRT1396169	hsa-miR-203	CLIP-seq
MIRT1396170	hsa-miR-3123	CLIP-seq
MIRT1396171	hsa-miR-4481	CLIP-seq
MIRT1396172	hsa-miR-4712-3p	CLIP-seq
MIRT1396173	hsa-miR-4745-5p	CLIP-seq
MIRT1396174	hsa-miR-4758-5p	CLIP-seq
MIRT1396175	hsa-miR-1245b-3p	CLIP-seq
MIRT1396176	hsa-miR-1253	CLIP-seq
MIRT1396177	hsa-miR-1305	CLIP-seq
MIRT1396178	hsa-miR-23a	CLIP-seq
MIRT1396179	hsa-miR-23b	CLIP-seq
MIRT1396180	hsa-miR-23c	CLIP-seq
MIRT1396181	hsa-miR-3171	CLIP-seq
MIRT1396182	hsa-miR-3185	CLIP-seq
MIRT1396183	hsa-miR-3190	CLIP-seq
MIRT1396184	hsa-miR-3200-5p	CLIP-seq
MIRT1396185	hsa-miR-329	CLIP-seq
MIRT1396186	hsa-miR-362-3p	CLIP-seq
MIRT1396187	hsa-miR-3915	CLIP-seq
MIRT1396188	hsa-miR-3922-5p	CLIP-seq
MIRT1396189	hsa-miR-3928	CLIP-seq
MIRT1396190	hsa-miR-3941	CLIP-seq
MIRT1396191	hsa-miR-3942-5p	CLIP-seq
MIRT1396192	hsa-miR-4263	CLIP-seq
MIRT1396193	hsa-miR-4312	CLIP-seq
MIRT1396194	hsa-miR-4426	CLIP-seq
MIRT1396195	hsa-miR-4434	CLIP-seq
MIRT1396196	hsa-miR-4477b	CLIP-seq
MIRT1396197	hsa-miR-4514	CLIP-seq
MIRT1396198	hsa-miR-4516	CLIP-seq
MIRT1396199	hsa-miR-4531	CLIP-seq
MIRT1396200	hsa-miR-4639-3p	CLIP-seq
MIRT1396201	hsa-miR-4647	CLIP-seq
MIRT1396202	hsa-miR-4649-3p	CLIP-seq
MIRT1396203	hsa-miR-4662b	CLIP-seq
MIRT1396204	hsa-miR-4684-5p	CLIP-seq
MIRT1396205	hsa-miR-4692	CLIP-seq
MIRT1396206	hsa-miR-4694-3p	CLIP-seq
MIRT1396207	hsa-miR-4703-5p	CLIP-seq
MIRT1396208	hsa-miR-4731-3p	CLIP-seq
MIRT1396209	hsa-miR-4735-5p	CLIP-seq
MIRT1396210	hsa-miR-4752	CLIP-seq
MIRT1396211	hsa-miR-4760-3p	CLIP-seq
MIRT1396212	hsa-miR-4793-5p	CLIP-seq
MIRT1396213	hsa-miR-4801	CLIP-seq
MIRT1396214	hsa-miR-498	CLIP-seq
MIRT1396215	hsa-miR-548u	CLIP-seq
MIRT1396216	hsa-miR-576-5p	CLIP-seq
MIRT1396217	hsa-miR-587	CLIP-seq
MIRT1396218	hsa-miR-603	CLIP-seq
MIRT1396219	hsa-miR-7	CLIP-seq
MIRT1396220	hsa-miR-1178	CLIP-seq
MIRT1396221	hsa-miR-1205	CLIP-seq
MIRT1396222	hsa-miR-140-5p	CLIP-seq
MIRT1396223	hsa-miR-196a	CLIP-seq
MIRT1396224	hsa-miR-196b	CLIP-seq
MIRT1396225	hsa-miR-22	CLIP-seq
MIRT1396184	hsa-miR-3200-5p	CLIP-seq
MIRT1396185	hsa-miR-329	CLIP-seq
MIRT1396226	hsa-miR-3545-5p	CLIP-seq
MIRT1396186	hsa-miR-362-3p	CLIP-seq
MIRT1396227	hsa-miR-3665	CLIP-seq
MIRT1396187	hsa-miR-3915	CLIP-seq
MIRT1396189	hsa-miR-3928	CLIP-seq
MIRT1396190	hsa-miR-3941	CLIP-seq
MIRT1396191	hsa-miR-3942-5p	CLIP-seq
MIRT1396228	hsa-miR-4460	CLIP-seq
MIRT1396200	hsa-miR-4639-3p	CLIP-seq
MIRT1396202	hsa-miR-4649-3p	CLIP-seq
MIRT1396204	hsa-miR-4684-5p	CLIP-seq
MIRT1396207	hsa-miR-4703-5p	CLIP-seq
MIRT1396208	hsa-miR-4731-3p	CLIP-seq
MIRT1396229	hsa-miR-4797-5p	CLIP-seq
MIRT1396213	hsa-miR-4801	CLIP-seq
MIRT1396218	hsa-miR-603	CLIP-seq
MIRT1396230	hsa-miR-657	CLIP-seq
MIRT1396231	hsa-miR-767-3p	CLIP-seq
MIRT1396232	hsa-miR-3154	CLIP-seq
MIRT1396233	hsa-miR-3616-5p	CLIP-seq
MIRT1396234	hsa-miR-3647-5p	CLIP-seq
MIRT1396235	hsa-miR-4795-5p	CLIP-seq
MIRT1396236	hsa-miR-573	CLIP-seq
MIRT2118810	hsa-miR-380	CLIP-seq
MIRT2118811	hsa-miR-4495	CLIP-seq
MIRT2118812	hsa-miR-4775	CLIP-seq
MIRT2118813	hsa-miR-548c-3p	CLIP-seq
MIRT2118814	hsa-miR-582-5p	CLIP-seq
MIRT2118815	hsa-miR-664	CLIP-seq
MIRT2395306	hsa-miR-130a	CLIP-seq
MIRT2395307	hsa-miR-130b	CLIP-seq
MIRT2395308	hsa-miR-142-3p	CLIP-seq
MIRT2395309	hsa-miR-153	CLIP-seq
MIRT2395310	hsa-miR-301a	CLIP-seq
MIRT2395311	hsa-miR-301b	CLIP-seq
MIRT2395312	hsa-miR-3666	CLIP-seq
MIRT2395313	hsa-miR-3674	CLIP-seq
MIRT2395314	hsa-miR-4295	CLIP-seq
MIRT2395315	hsa-miR-448	CLIP-seq
MIRT2395316	hsa-miR-454	CLIP-seq
MIRT2395317	hsa-miR-4671-3p	CLIP-seq
MIRT2460649	hsa-miR-223	CLIP-seq
MIRT1396227	hsa-miR-3665	CLIP-seq
MIRT2460650	hsa-miR-4736	CLIP-seq
MIRT2118812	hsa-miR-4775	CLIP-seq
MIRT2460651	hsa-miR-764	CLIP-seq
MIRT2634932	hsa-miR-141	CLIP-seq
MIRT2634933	hsa-miR-200a	CLIP-seq
MIRT2634934	hsa-miR-204	CLIP-seq
MIRT2634935	hsa-miR-211	CLIP-seq
MIRT1396178	hsa-miR-23a	CLIP-seq
MIRT1396179	hsa-miR-23b	CLIP-seq
MIRT1396180	hsa-miR-23c	CLIP-seq
MIRT2634936	hsa-miR-3143	CLIP-seq
MIRT2634937	hsa-miR-3692	CLIP-seq
MIRT2634938	hsa-miR-383	CLIP-seq
MIRT2634939	hsa-miR-3925-3p	CLIP-seq
MIRT2634940	hsa-miR-4424	CLIP-seq
MIRT2634941	hsa-miR-4444	CLIP-seq
MIRT2634942	hsa-miR-4446-5p	CLIP-seq
MIRT2634943	hsa-miR-4503	CLIP-seq
MIRT2634944	hsa-miR-4522	CLIP-seq
MIRT2634945	hsa-miR-4690-5p	CLIP-seq
MIRT2634946	hsa-miR-4695-3p	CLIP-seq
MIRT2634947	hsa-miR-4712-5p	CLIP-seq
MIRT2634948	hsa-miR-4738-3p	CLIP-seq
MIRT2634949	hsa-miR-4755-5p	CLIP-seq
MIRT2634950	hsa-miR-516a-5p	CLIP-seq
MIRT2634951	hsa-miR-543	CLIP-seq
MIRT2634952	hsa-miR-544	CLIP-seq
MIRT2634953	hsa-miR-579	CLIP-seq
MIRT2634954	hsa-miR-606	CLIP-seq
MIRT2634955	hsa-miR-623	CLIP-seq
MIRT2634956	hsa-miR-645	CLIP-seq
MIRT2634957	hsa-miR-659	CLIP-seq
MIRT2634958	hsa-miR-770-5p	CLIP-seq
MIRT2634932	hsa-miR-141	CLIP-seq
MIRT2634933	hsa-miR-200a	CLIP-seq
MIRT2634938	hsa-miR-383	CLIP-seq
MIRT2634939	hsa-miR-3925-3p	CLIP-seq
MIRT2634940	hsa-miR-4424	CLIP-seq
MIRT2634941	hsa-miR-4444	CLIP-seq
MIRT2634943	hsa-miR-4503	CLIP-seq
MIRT2634945	hsa-miR-4690-5p	CLIP-seq
MIRT2634946	hsa-miR-4695-3p	CLIP-seq
MIRT2634947	hsa-miR-4712-5p	CLIP-seq
MIRT2634950	hsa-miR-516a-5p	CLIP-seq
MIRT2634952	hsa-miR-544	CLIP-seq
MIRT2634956	hsa-miR-645	CLIP-seq
MIRT2634958	hsa-miR-770-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0005515	Function	Protein binding	IPI	21903422, 23125361
GO:0005730	Component	Nucleolus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005874	Component	Microtubule	IEA
GO:0016020	Component	Membrane	HDA	19946888

Other IDs

• MIM: 605920
• HGNC: 11371
• e!Ensembl: ENSG00000040341

Protein

• UniProt ID: Q9NUL3
• Protein name: Double-stranded RNA-binding protein Staufen homolog 2
• Protein function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for n
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00035	dsrm	9 → 72	Double-stranded RNA binding motif	Domain
  PF00035	dsrm	127 → 179	Double-stranded RNA binding motif	Domain
  PF00035	dsrm	208 → 272	Double-stranded RNA binding motif	Domain
  PF00035	dsrm	308 → 373	Double-stranded RNA binding motif	Domain
  PF16482	Staufen_C	455 → 523	Staufen C-terminal domain	Domain

• Sequence:

  MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKK
  AQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKP
  FPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQ
  NEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFV
  TRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGP
  EYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKI
  AKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVY
  QEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAI
  GLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMNIEKGSLEK
  QAKHLREKADNNQAPPGSIAQDCKKSNSAV

• Sequence length: 570

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS
Leprosy	Leprosy			GWAS
Insomnia	Insomnia			GWAS
Renal Carcinoma	Renal Carcinoma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Stimulate	33441653
Colorectal Neoplasms	Associate	26843428
Heart Failure Diastolic	Associate	28105587
Neoplasms	Associate	33441653, 35942760