Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27044
Gene name	Staphylococcal nuclease and tudor domain containing 1
Gene symbol	SND1
Synonyms (NCBI Gene)	TDRD11TSNTudor-SNp100
Chromosome	7
Chromosome location	7q32.1
Summary	This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interac

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029612	hsa-miR-26b-5p	Microarray	19088304
MIRT051278	hsa-miR-16-5p	CLASH	23622248
MIRT048839	hsa-miR-93-5p	CLASH	23622248
MIRT036835	hsa-miR-877-3p	CLASH	23622248
MIRT438339	hsa-miR-361-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	25965817
MIRT438339	hsa-miR-361-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	25965817
MIRT438339	hsa-miR-361-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	25965817
MIRT438339	hsa-miR-361-5p	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	25965817
MIRT641891	hsa-miR-1470	HITS-CLIP	23824327
MIRT641890	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT641889	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT641888	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641887	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641886	hsa-miR-4469	HITS-CLIP	23824327
MIRT641885	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT641884	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT641883	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT641882	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT641881	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT467439	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT467440	hsa-miR-4270	PAR-CLIP	23592263
MIRT467438	hsa-miR-4441	PAR-CLIP	23592263
MIRT467437	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT467436	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT467435	hsa-miR-4685-5p	PAR-CLIP	23592263
MIRT467434	hsa-miR-6837-5p	PAR-CLIP	23592263
MIRT467433	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT467432	hsa-miR-4434	PAR-CLIP	23592263
MIRT467431	hsa-miR-4516	PAR-CLIP	23592263
MIRT467430	hsa-miR-5703	PAR-CLIP	23592263
MIRT467428	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT467429	hsa-miR-198	PAR-CLIP	23592263
MIRT731070	hsa-miR-184	qRT-PCRLuciferase reporter assayImmunofluorescenceImmunohistochemistryWestern blot	25216670
MIRT731070	hsa-miR-184	qRT-PCRLuciferase reporter assayImmunofluorescenceImmunohistochemistryWestern blot	25216670
MIRT736681	hsa-miR-296-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	33652459
MIRT641891	hsa-miR-1470	HITS-CLIP	23824327
MIRT641890	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT641889	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT641888	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641887	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641886	hsa-miR-4469	HITS-CLIP	23824327
MIRT641885	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT641884	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT641883	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT641882	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT641881	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT467439	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT467440	hsa-miR-4270	PAR-CLIP	23592263
MIRT467438	hsa-miR-4441	PAR-CLIP	23592263
MIRT467437	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT467436	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT467435	hsa-miR-4685-5p	PAR-CLIP	23592263
MIRT467434	hsa-miR-6837-5p	PAR-CLIP	23592263
MIRT467433	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT467432	hsa-miR-4434	PAR-CLIP	23592263
MIRT467431	hsa-miR-4516	PAR-CLIP	23592263
MIRT467430	hsa-miR-5703	PAR-CLIP	23592263
MIRT467428	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT467429	hsa-miR-198	PAR-CLIP	23592263
MIRT1375447	hsa-miR-3192	CLIP-seq
MIRT1375448	hsa-miR-3616-3p	CLIP-seq
MIRT1375449	hsa-miR-4314	CLIP-seq
MIRT1375450	hsa-miR-4436b-3p	CLIP-seq
MIRT1375451	hsa-miR-4487	CLIP-seq
MIRT1375452	hsa-miR-4646-5p	CLIP-seq
MIRT1375453	hsa-miR-548aa	CLIP-seq
MIRT1375454	hsa-miR-622	CLIP-seq
MIRT1375447	hsa-miR-3192	CLIP-seq
MIRT1375448	hsa-miR-3616-3p	CLIP-seq
MIRT1553879	hsa-miR-421	CLIP-seq
MIRT1375449	hsa-miR-4314	CLIP-seq
MIRT1375450	hsa-miR-4436b-3p	CLIP-seq
MIRT1375451	hsa-miR-4487	CLIP-seq
MIRT1553880	hsa-miR-4520a-3p	CLIP-seq
MIRT1553881	hsa-miR-4520b-3p	CLIP-seq
MIRT1375452	hsa-miR-4646-5p	CLIP-seq
MIRT1553882	hsa-miR-4709-5p	CLIP-seq
MIRT1375454	hsa-miR-622	CLIP-seq
MIRT2111639	hsa-miR-1827	CLIP-seq
MIRT1375447	hsa-miR-3192	CLIP-seq
MIRT1553879	hsa-miR-421	CLIP-seq
MIRT1375449	hsa-miR-4314	CLIP-seq
MIRT1553880	hsa-miR-4520a-3p	CLIP-seq
MIRT1553881	hsa-miR-4520b-3p	CLIP-seq
MIRT1375452	hsa-miR-4646-5p	CLIP-seq
MIRT1553882	hsa-miR-4709-5p	CLIP-seq
MIRT2111640	hsa-miR-548c-3p	CLIP-seq
MIRT1375454	hsa-miR-622	CLIP-seq
MIRT2111641	hsa-miR-940	CLIP-seq
MIRT2334811	hsa-miR-1256	CLIP-seq
MIRT2334812	hsa-miR-1324	CLIP-seq
MIRT2334813	hsa-miR-3158-5p	CLIP-seq
MIRT2334814	hsa-miR-3166	CLIP-seq
MIRT2334815	hsa-miR-3170	CLIP-seq
MIRT2334816	hsa-miR-4446-3p	CLIP-seq
MIRT2334817	hsa-miR-4771	CLIP-seq
MIRT2111640	hsa-miR-548c-3p	CLIP-seq
MIRT2334818	hsa-miR-580	CLIP-seq
MIRT2691611	hsa-miR-1283	CLIP-seq
MIRT2334815	hsa-miR-3170	CLIP-seq
MIRT2691612	hsa-miR-3183	CLIP-seq
MIRT2691613	hsa-miR-320a	CLIP-seq
MIRT2691614	hsa-miR-320b	CLIP-seq
MIRT2691615	hsa-miR-320c	CLIP-seq
MIRT2691616	hsa-miR-320d	CLIP-seq
MIRT2691617	hsa-miR-320e	CLIP-seq
MIRT2691618	hsa-miR-326	CLIP-seq
MIRT2691619	hsa-miR-330-5p	CLIP-seq
MIRT2691620	hsa-miR-4429	CLIP-seq
MIRT2691621	hsa-miR-4667-5p	CLIP-seq
MIRT2691622	hsa-miR-4700-5p	CLIP-seq
MIRT2691623	hsa-miR-4723-3p	CLIP-seq
MIRT2691624	hsa-miR-637	CLIP-seq
MIRT2691625	hsa-miR-711	CLIP-seq

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Transcription factor	Regulation	Reference
NFKB2	Activation	20363924

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003712	Function	Transcription coregulator activity	TAS	7651391
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	18453631
GO:0004518	Function	Nuclease activity	IBA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IDA	18453631
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IDA	28546213
GO:0005515	Function	Protein binding	IPI	20643132, 20937909, 24882364, 24981741, 28514442, 28546213, 33961781, 34591612
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7651391
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006402	Process	MRNA catabolic process	IBA
GO:0010564	Process	Regulation of cell cycle process	IMP	28546213
GO:0010587	Process	MiRNA catabolic process	IDA	28546213
GO:0016020	Component	Membrane	HDA	16210410
GO:0016787	Function	Hydrolase activity	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031332	Component	RNAi effector complex	IEA
GO:0042470	Component	Melanosome	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0097433	Component	Dense body	IEA
GO:1905172	Function	RISC complex binding	IDA	28546213

MIM	HGNC	e!Ensembl
602181	30646	ENSG00000197157

Q7KZF4

Protein name

Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)

Protein function

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a

PDB

2E6N , 2HQE , 2HQX , 2O4X , 3BDL , 3OMC , 3OMG , 4QMG , 5M9O , 7KNW , 7KNX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00565	SNase	48 → 166	Staphylococcal nuclease homologue	Domain
PF00565	SNase	220 → 328	Staphylococcal nuclease homologue	Domain
PF00565	SNase	367 → 496	Staphylococcal nuclease homologue	Domain
PF00565	SNase	552 → 660	Staphylococcal nuclease homologue	Domain
PF00567	TUDOR	677 → 799	Tudor domain	Domain
PF00565	SNase	837 → 895	Staphylococcal nuclease homologue	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:7651391}.

Sequence

MASSAQSGGSSGGPAVPTVQRGIIKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLA
RRAAATQPDAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNG
ENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTIRDLKYTI
ENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSET
PEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWS
IAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKL
NSGDYKTIHLSSIRPPRLEGENTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVD
YIRPASPATETVPAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELL
AAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRL
KLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVES
MDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAH
YEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIAS
HPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTL
SPAFSTRVLPAQATEYAFAFIQVPQDDDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHV
TLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRA
DDADEFGYSR

Sequence length

910

Interactions

View interactions

	KEGG		Reactome
	Viral carcinogenesis		Signaling by BRAF and RAF fusions

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Uncertain significance	rs145473877	RCV005939219
Hepatocellular carcinoma	Uncertain significance	rs145473877	RCV005939218
Hypospadias	Uncertain significance	rs200084233	RCV001824100
Long QT syndrome	Likely benign	rs796052170	RCV000190167
Malignant tumor of urinary bladder	Uncertain significance	rs145473877	RCV005939217
Ovarian serous cystadenocarcinoma	Uncertain significance	rs145473877	RCV005939220
SND1-related disorder	Uncertain significance; Likely benign	rs1802509838, rs144683326	RCV003894043 RCV003971376
Teratoma	Uncertain significance	rs773076395	RCV003221373

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	25985019, 32645525
Adenoma	Associate	37779184
Alzheimer Disease	Associate	31377428
Autistic Disorder	Associate	20442744
Breast Neoplasms	Associate	24155205, 35121988, 37885030
Carcinogenesis	Associate	26323317
Carcinoma Hepatocellular	Associate	22396537, 25494629, 30321081
Carcinoma Non Small Cell Lung	Stimulate	25940438
Carcinoma Renal Cell	Associate	31978894
Cell Transformation Neoplastic	Stimulate	22396537
Cleft Palate	Associate	32241273
Colonic Neoplasms	Associate	32645525
Colorectal Neoplasms	Associate	23867710, 37779184
Embolism Fat	Associate	30901032
Glioma	Associate	28160566, 31253583, 36213325, 37202791
Hypoxia	Associate	25494629
Inflammation	Associate	25494629, 26323317
Leukemia Lymphocytic Chronic B Cell	Associate	25793711
Lung Neoplasms	Associate	29159900
Melanoma	Associate	32645525
Neoplasm Metastasis	Associate	24155205, 29159900, 36213325, 37885030
Neoplasms	Associate	19435788, 22396537, 24155205, 25494629, 28884748, 32645525, 35659036, 36213325, 37885030
Neoplasms	Inhibit	28160566, 35121988
Osteosarcoma	Associate	31799644
Pancreatic Neoplasms	Associate	34476331
Prostatic Neoplasms	Associate	19435788, 25189356, 28403887, 35659274
Retinoblastoma	Associate	34969359
Stomach Neoplasms	Associate	35739527
Testicular Germ Cell Tumor	Associate	32645525
Thyroid Neoplasms	Associate	32737449
Triple Negative Breast Neoplasms	Associate	37885030
Urinary Bladder Neoplasms	Associate	36453257, 38176295

SND1 (staphylococcal nuclease and tudor domain containing 1)