PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel)

Gene

• Entrez ID: 27039
• Gene name: Polycystin 2 like 2, transient receptor potential cation channel
• Gene symbol: PKD2L2
• Synonyms (NCBI Gene): TRPP5
• Chromosome: 5
• Chromosome location: 5q31.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT441454	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT441454	hsa-miR-9-3p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005262	Function	Calcium channel activity	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10602361
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0050982	Process	Detection of mechanical stimulus	IBA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

Other IDs

• MIM: 604669
• HGNC: 9012
• e!Ensembl: ENSG00000078795

Protein

• UniProt ID: Q9NZM6
• Protein name: Polycystin-2-like protein 2 (Polycystin-2L2) (Polycystic kidney disease 2-like 2 protein) (Polycystin-L2)
• Protein function: Exhibits a lower single conductance but no spontaneous channel activity (PubMed:16883570). May function as a regulator of calcium channels or a channel component involving Ca2(+) homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9JLG4, ECO:00
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08016	PKD_channel	75 → 497	Polycystin cation channel	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed only in testis (PubMed:10602361). Expressed also in brain and kidney (PubMed:10756092). {ECO:0000269|PubMed:10602361, ECO:0000269|PubMed:10756092}.; TISSUE SPECIFICITY: [Isoform 2]: Expressed only in transformed lymphoblasts.
• Sequence:

  MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
  MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
  YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
  SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
  NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
  VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
  LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
  YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
  VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
  GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
  VELEKELHYINLKLNQVVRKVSAL

• Sequence length: 624