Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27037
Gene name Gene Name - the full gene name approved by the HGNC.	TRNA methyltransferase 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRMT2A
Synonyms (NCBI Gene) Gene synonyms aliases	HTF9C
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biom

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029799	hsa-miR-26b-5p	Microarray	19088304
MIRT045766	hsa-miR-125a-5p	CLASH	23622248
MIRT041422	hsa-miR-193b-3p	CLASH	23622248
MIRT037605	hsa-miR-744-5p	CLASH	23622248
MIRT1456797	hsa-miR-4427	CLIP-seq
MIRT1456798	hsa-miR-4680-3p	CLIP-seq
MIRT1456799	hsa-miR-604	CLIP-seq
MIRT1456800	hsa-miR-647	CLIP-seq
MIRT1456801	hsa-miR-938	CLIP-seq
MIRT2136885	hsa-miR-653	CLIP-seq
MIRT2357676	hsa-miR-1224-3p	CLIP-seq
MIRT2357677	hsa-miR-1343	CLIP-seq
MIRT2357678	hsa-miR-3127-5p	CLIP-seq
MIRT2357679	hsa-miR-3918	CLIP-seq
MIRT2357680	hsa-miR-4421	CLIP-seq
MIRT1456797	hsa-miR-4427	CLIP-seq
MIRT2462396	hsa-miR-4435	CLIP-seq
MIRT2651347	hsa-miR-1291	CLIP-seq
MIRT2651348	hsa-miR-4292	CLIP-seq
MIRT2651349	hsa-miR-4450	CLIP-seq
MIRT2651350	hsa-miR-4667-5p	CLIP-seq
MIRT2651351	hsa-miR-4700-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	31361898
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008169	Function	C-methyltransferase activity	IDA	34123281, 34556860
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030697	Function	TRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA	31361898, 33799331
GO:0030697	Function	TRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IEA
GO:0032259	Process	Methylation	IEA

MIM	HGNC	e!Ensembl
611151	24974	ENSG00000099899

Protein

UniProt ID

Q8IZ69

Protein name

tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-)

Protein function

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54)

PDB

7NTN , 7NTO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05958	tRNA_U5-meth_tr	395 → 589	tRNA (Uracil-5-)-methyltransferase	Family

Sequence

MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY
SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA
ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY
AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR
NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP
YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA
SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL
YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELS
NVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNP
RAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGP
HSPPAQPTPGPPDNTLQETGTFPSS

Sequence length

625

Interactions

View interactions

TRMT2A (tRNA methyltransferase 2A)