GJA4 (gap junction protein alpha 4)

Gene

• Entrez ID: 2701
• Gene name: Gap junction protein alpha 4
• Gene symbol: GJA4
• Synonyms (NCBI Gene): CX37
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1019693	hsa-miR-1254	CLIP-seq
MIRT1019694	hsa-miR-2467-3p	CLIP-seq
MIRT1019695	hsa-miR-296-5p	CLIP-seq
MIRT1019696	hsa-miR-3116	CLIP-seq
MIRT1019697	hsa-miR-3158-5p	CLIP-seq
MIRT1019698	hsa-miR-361-3p	CLIP-seq
MIRT1019699	hsa-miR-3614-3p	CLIP-seq
MIRT1019700	hsa-miR-3678-3p	CLIP-seq
MIRT1019701	hsa-miR-371-3p	CLIP-seq
MIRT1019702	hsa-miR-371b-3p	CLIP-seq
MIRT1019703	hsa-miR-4297	CLIP-seq
MIRT1019704	hsa-miR-4456	CLIP-seq
MIRT1019705	hsa-miR-4459	CLIP-seq
MIRT1019706	hsa-miR-4712-5p	CLIP-seq
MIRT1019707	hsa-miR-4733-3p	CLIP-seq
MIRT1019708	hsa-miR-4753-5p	CLIP-seq
MIRT1019709	hsa-miR-4779	CLIP-seq
MIRT1019710	hsa-miR-486-3p	CLIP-seq
MIRT1019711	hsa-miR-515-3p	CLIP-seq
MIRT1019712	hsa-miR-519e	CLIP-seq
MIRT1019713	hsa-miR-541	CLIP-seq
MIRT1019714	hsa-miR-550a	CLIP-seq
MIRT1019715	hsa-miR-654-5p	CLIP-seq
MIRT1019716	hsa-miR-661	CLIP-seq
MIRT1019717	hsa-miR-665	CLIP-seq
MIRT1019718	hsa-miR-770-5p	CLIP-seq
MIRT2001970	hsa-miR-4514	CLIP-seq
MIRT2001971	hsa-miR-4692	CLIP-seq
MIRT2235013	hsa-miR-3922-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001568	Process	Blood vessel development	IEA
GO:0005243	Function	Gap junction channel activity	IBA
GO:0005515	Function	Protein binding	IPI	23840749, 28298427, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7680674
GO:0005921	Component	Gap junction	IEA
GO:0005921	Component	Gap junction	TAS	7680674
GO:0005922	Component	Connexin complex	IBA
GO:0005922	Component	Connexin complex	IEA
GO:0007043	Process	Cell-cell junction assembly	TAS	7680674
GO:0007154	Process	Cell communication	IEA
GO:0007267	Process	Cell-cell signaling	IBA
GO:0016020	Component	Membrane	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 121012
• HGNC: 4278
• e!Ensembl: ENSG00000187513

Protein

• UniProt ID: P35212
• Protein name: Gap junction alpha-4 protein (Connexin-37) (Cx37)
• Protein function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00029	Connexin	3 → 233	Connexin	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium.
• Sequence:

  MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG
  CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKD
  PQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWT
  MEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGM
  RARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERL
  ASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV

• Sequence length: 333

Pathways

Reactome:

Gap junction assembly

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