Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2686
Gene name Gene Name - the full gene name approved by the HGNC.	Gamma-glutamyltransferase 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GGT7
Synonyms (NCBI Gene) Gene synonyms aliases	D20S101, GGT4, GGTL3, GGTL5
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q11.22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the

Show/Hide all(213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043545	hsa-miR-331-3p	CLASH	23622248
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	28735896
MIRT611133	hsa-miR-197-3p	HITS-CLIP	28735896
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	28735896
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	28735896
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT1018337	hsa-miR-1183	CLIP-seq
MIRT1018338	hsa-miR-1254	CLIP-seq
MIRT1018339	hsa-miR-1292	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018341	hsa-miR-3064-5p	CLIP-seq
MIRT1018342	hsa-miR-3116	CLIP-seq
MIRT1018343	hsa-miR-3117-5p	CLIP-seq
MIRT1018344	hsa-miR-3126-5p	CLIP-seq
MIRT1018345	hsa-miR-3173-3p	CLIP-seq
MIRT1018346	hsa-miR-3192	CLIP-seq
MIRT1018347	hsa-miR-326	CLIP-seq
MIRT1018348	hsa-miR-330-5p	CLIP-seq
MIRT1018349	hsa-miR-3935	CLIP-seq
MIRT1018350	hsa-miR-4314	CLIP-seq
MIRT1018351	hsa-miR-4471	CLIP-seq
MIRT1018352	hsa-miR-4522	CLIP-seq
MIRT1018353	hsa-miR-4646-5p	CLIP-seq
MIRT1018354	hsa-miR-4687-3p	CLIP-seq
MIRT1018355	hsa-miR-4718	CLIP-seq
MIRT1018356	hsa-miR-4728-3p	CLIP-seq
MIRT1018357	hsa-miR-4779	CLIP-seq
MIRT1018358	hsa-miR-628-5p	CLIP-seq
MIRT1018359	hsa-miR-661	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018346	hsa-miR-3192	CLIP-seq
MIRT1018347	hsa-miR-326	CLIP-seq
MIRT1018348	hsa-miR-330-5p	CLIP-seq
MIRT1018350	hsa-miR-4314	CLIP-seq
MIRT1018353	hsa-miR-4646-5p	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12270127, 25416956, 25910212, 31515488, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12270127
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0006750	Process	Glutathione biosynthetic process	IEA
GO:0006751	Process	Glutathione catabolic process	IBA
GO:0006751	Process	Glutathione catabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0036374	Function	Glutathione hydrolase activity	IBA
GO:0036374	Function	Glutathione hydrolase activity	IEA
GO:0103068	Function	Leukotriene C4 gamma-glutamyl transferase activity	IEA
GO:1901750	Process	Leukotriene D4 biosynthetic process	ISS
GO:1902883	Process	Negative regulation of response to oxidative stress	IMP	25884624

MIM	HGNC	e!Ensembl
612342	4259	ENSG00000131067

Protein

UniProt ID

Q9UJ14

Protein name

Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathion

Protein function

Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01019	G_glu_transpept	154 → 655		Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

Sequence

MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
FLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATG
VTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVAPH
SSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLH
EAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQLPPNMSERFRETFLPSGRPPL
PGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEK
PVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALAS
RLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMG
PDDFIVAMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPL
SFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDL
QSNLLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGAT
IL

Sequence length

662

Interactions

View interactions

	KEGG		Reactome
	Taurine and hypotaurine metabolism Glutathione metabolism Metabolic pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Osteoporosis	Associate	27856519
Osteoporotic Fractures	Associate	27856519

GGT7 (gamma-glutamyltransferase 7)