PGBD2 (piggyBac transposable element derived 2)

Gene

• Entrez ID: 267002
• Gene name: PiggyBac transposable element derived 2
• Gene symbol: PGBD2
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q44
• Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1227179	hsa-miR-10a	CLIP-seq
MIRT1227180	hsa-miR-10b	CLIP-seq
MIRT1227181	hsa-miR-25	CLIP-seq
MIRT1227182	hsa-miR-302f	CLIP-seq
MIRT1227183	hsa-miR-30a	CLIP-seq
MIRT1227184	hsa-miR-30b	CLIP-seq
MIRT1227185	hsa-miR-30c	CLIP-seq
MIRT1227186	hsa-miR-30d	CLIP-seq
MIRT1227187	hsa-miR-30e	CLIP-seq
MIRT1227188	hsa-miR-32	CLIP-seq
MIRT1227189	hsa-miR-340	CLIP-seq
MIRT1227190	hsa-miR-3607-3p	CLIP-seq
MIRT1227191	hsa-miR-363	CLIP-seq
MIRT1227192	hsa-miR-367	CLIP-seq
MIRT1227193	hsa-miR-4528	CLIP-seq
MIRT1227194	hsa-miR-4742-3p	CLIP-seq
MIRT1227195	hsa-miR-92a	CLIP-seq
MIRT1227196	hsa-miR-92b	CLIP-seq
MIRT1227197	hsa-miR-1264	CLIP-seq
MIRT1227198	hsa-miR-2116	CLIP-seq
MIRT1227199	hsa-miR-216a	CLIP-seq
MIRT1227200	hsa-miR-23a	CLIP-seq
MIRT1227201	hsa-miR-23b	CLIP-seq
MIRT1227202	hsa-miR-23c	CLIP-seq
MIRT1227181	hsa-miR-25	CLIP-seq
MIRT1227182	hsa-miR-302f	CLIP-seq
MIRT1227183	hsa-miR-30a	CLIP-seq
MIRT1227184	hsa-miR-30b	CLIP-seq
MIRT1227185	hsa-miR-30c	CLIP-seq
MIRT1227186	hsa-miR-30d	CLIP-seq
MIRT1227187	hsa-miR-30e	CLIP-seq
MIRT1227188	hsa-miR-32	CLIP-seq
MIRT1227203	hsa-miR-342-3p	CLIP-seq
MIRT1227190	hsa-miR-3607-3p	CLIP-seq
MIRT1227191	hsa-miR-363	CLIP-seq
MIRT1227204	hsa-miR-3646	CLIP-seq
MIRT1227205	hsa-miR-3662	CLIP-seq
MIRT1227192	hsa-miR-367	CLIP-seq
MIRT1227206	hsa-miR-452	CLIP-seq
MIRT1227207	hsa-miR-4676-3p	CLIP-seq
MIRT1227208	hsa-miR-4677-5p	CLIP-seq
MIRT1227209	hsa-miR-4693-5p	CLIP-seq
MIRT1227194	hsa-miR-4742-3p	CLIP-seq
MIRT1227210	hsa-miR-4769-3p	CLIP-seq
MIRT1227211	hsa-miR-4778-3p	CLIP-seq
MIRT1227212	hsa-miR-548c-3p	CLIP-seq
MIRT1227213	hsa-miR-550b	CLIP-seq
MIRT1227195	hsa-miR-92a	CLIP-seq
MIRT1227196	hsa-miR-92b	CLIP-seq
MIRT1227179	hsa-miR-10a	CLIP-seq
MIRT1227180	hsa-miR-10b	CLIP-seq
MIRT1227200	hsa-miR-23a	CLIP-seq
MIRT1227201	hsa-miR-23b	CLIP-seq
MIRT1227202	hsa-miR-23c	CLIP-seq
MIRT2066567	hsa-miR-3145-3p	CLIP-seq
MIRT2066568	hsa-miR-4666-5p	CLIP-seq
MIRT2066569	hsa-miR-4704-5p	CLIP-seq
MIRT2066570	hsa-miR-4789-5p	CLIP-seq
MIRT2294111	hsa-miR-302a	CLIP-seq
MIRT2294112	hsa-miR-302b	CLIP-seq
MIRT2294113	hsa-miR-302c	CLIP-seq
MIRT2294114	hsa-miR-302d	CLIP-seq
MIRT2294115	hsa-miR-302e	CLIP-seq
MIRT1227183	hsa-miR-30a	CLIP-seq
MIRT1227184	hsa-miR-30b	CLIP-seq
MIRT1227185	hsa-miR-30c	CLIP-seq
MIRT1227186	hsa-miR-30d	CLIP-seq
MIRT1227187	hsa-miR-30e	CLIP-seq
MIRT1227190	hsa-miR-3607-3p	CLIP-seq
MIRT2294116	hsa-miR-372	CLIP-seq
MIRT2294117	hsa-miR-373	CLIP-seq
MIRT1227193	hsa-miR-4528	CLIP-seq
MIRT1227194	hsa-miR-4742-3p	CLIP-seq
MIRT2294118	hsa-miR-520a-3p	CLIP-seq
MIRT2294119	hsa-miR-520b	CLIP-seq
MIRT2294120	hsa-miR-520c-3p	CLIP-seq
MIRT2294121	hsa-miR-520d-3p	CLIP-seq
MIRT2294122	hsa-miR-520e	CLIP-seq
MIRT2592088	hsa-miR-4445	CLIP-seq
MIRT2592089	hsa-miR-494	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0043565	Function	Sequence-specific DNA binding	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6P3X8
• Protein name: PiggyBac transposable element-derived protein 2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13843	DDE_Tnp_1_7	140 → 499	Transposase IS4	Domain

• Sequence:

  MASTSRDVIAGRGIHSKVKSAKLLEVLNAMEEEESNNNREEIFIAPPDNAAGEFTDEDSG
  DEDSQRGAHLPGSVLHASVLCEDSGTGEDNDDLELQPAKKRQKAVVKPQRIWTKRDIRPD
  FGSWTASDPHIEDLKSQELSPVGLFELFFDEGTINFIVNETNRYAWQKNVNLSLTAQELK
  CVLGILILSGYISYPRRRMFWETSPDSHHHLVADAIRRDRFELIFSYLHFADNNELDASD
  RFAKVRPLIIRMNCNFQKHAPLEEFYSFGESMCEYFGHRGSKQLHRGKPVRLGYKIWCGT
  TSRGYLVWFEPSQGTLFTKPDRSLDLGGSMVIKFVDALQERGFLPYHIFFDKVFTSVKLM
  SILRKKGVKATGTVREYRTERCPLKDPKELKKMKRGSFDYKVDESEEIIVCRWHDSSVVN
  ICSNAVGIEPVRLTSRHSGAAKTRTQVHQPSLVKLYQEKVGGVGRMDQNIAKYKVKIRGM
  KWYSSFIGYVIDAALNNAWQLHRICCQDAQVDLLAFRRYIACVYLESNADTTSQGRRSRR
  LETESRFDMIGHWIIHQDKRTRCALCHSQTNTRCEKCQKGVHAKCFREYHIR

• Sequence length: 592

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations