Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
266722
Gene name Gene Name - the full gene name approved by the HGNC.
Heparan sulfate 6-O-sulfotransferase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HS6ST3
Synonyms (NCBI Gene) Gene synonyms aliases
HS6ST-3
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018336 hsa-miR-335-5p Microarray 18185580
MIRT607779 hsa-miR-4688 HITS-CLIP 19536157
MIRT607778 hsa-miR-6743-5p HITS-CLIP 19536157
MIRT607775 hsa-miR-486-3p HITS-CLIP 19536157
MIRT607774 hsa-miR-597-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0015015 Process Heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA 21873635
GO:0016021 Component Integral component of membrane IEA
GO:0017095 Function Heparan sulfate 6-O-sulfotransferase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609401 19134 ENSG00000185352
Protein
UniProt ID Q8IZP7
Protein name Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST-3) (EC 2.8.2.-)
Protein function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03567 Sulfotransfer_2 138 411 Sulfotransferase family Domain
Sequence
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQA
PPEEWERRPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSL
PRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYY
ITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMD
CTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT
QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYA
KDLFQQRYH
HTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW
Sequence length 471
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosaminoglycan biosynthesis - heparan sulfate / heparin   HS-GAG biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Narcolepsy Narcolepsy rs104894574, rs387906655 19629137
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
23563607
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Diabetic Retinopathy Diabetic Retinopathy GWAS
Gout Gout GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Diabetes Mellitus Type 2 Associate 27863428
Obesity Associate 23563607