Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2665
Gene name Gene Name - the full gene name approved by the HGNC.
GDP dissociation inhibitor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GDI2
Synonyms (NCBI Gene) Gene synonyms aliases
HEL-S-46e, RABGDIB
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p15.1
Summary Summary of gene provided in NCBI Entrez Gene.
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051332 hsa-miR-15a-5p CLASH 23622248
MIRT050494 hsa-miR-20a-5p CLASH 23622248
MIRT047863 hsa-miR-30c-5p CLASH 23622248
MIRT046604 hsa-miR-222-3p CLASH 23622248
MIRT043759 hsa-miR-328-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0005093 Function Rab GDP-dissociation inhibitor activity IBA 21873635
GO:0005096 Function GTPase activator activity IEA
GO:0005515 Function Protein binding IPI 11809807, 19570034, 20176951, 25860027
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600767 4227 ENSG00000057608
Protein
UniProt ID P50395
Protein name Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)
Protein function GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein tran
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00996 GDI 1 436 GDP dissociation inhibitor Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:7543319}.
Sequence
Sequence length 445
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Neutrophil degranulation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Unknown
Disease term Disease name Evidence References Source
Breast cancer Breast cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 34894398
Carcinoma Non Small Cell Lung Associate 25367783
Esophageal Squamous Cell Carcinoma Associate 20686364
Glioblastoma Associate 35111402
Insulin Resistance Associate 32293066
Lung Neoplasms Associate 25367783
Multiple Sclerosis Associate 23692923
Neoplasms Associate 32945458, 34894398
Obesity Associate 32293066
Thyroid Neoplasms Associate 32945458