Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26578
Gene name	Osteoclast stimulating factor 1
Gene symbol	OSTF1
Synonyms (NCBI Gene)	OSFSH3P2bA235O14.1
Chromosome	9
Chromosome location	9q21.13
Summary	Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

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Show/Hide all (265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006863	hsa-miR-429	Luciferase reporter assay	22940129
MIRT023985	hsa-miR-1-3p	Proteomics	18668040
MIRT029977	hsa-miR-26b-5p	Microarray	19088304
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT671996	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671995	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671994	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT671993	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT671992	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671991	hsa-miR-6131	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671990	hsa-miR-548s	HITS-CLIP	23824327
MIRT671989	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671988	hsa-miR-588	HITS-CLIP	23824327
MIRT671987	hsa-miR-4435	HITS-CLIP	23824327
MIRT671986	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671985	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671984	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT671996	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671995	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671994	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT667090	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671993	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT671992	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671991	hsa-miR-6131	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671990	hsa-miR-548s	HITS-CLIP	23824327
MIRT671989	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671988	hsa-miR-588	HITS-CLIP	23824327
MIRT671987	hsa-miR-4435	HITS-CLIP	23824327
MIRT671986	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671985	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671984	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT622958	hsa-miR-6844	HITS-CLIP	23824327
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT667090	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT622958	hsa-miR-6844	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516925	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT516924	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT516926	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516925	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT516924	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT671996	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671995	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671994	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT671993	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT671992	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671991	hsa-miR-6131	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671990	hsa-miR-548s	HITS-CLIP	23824327
MIRT671989	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671988	hsa-miR-588	HITS-CLIP	23824327
MIRT671987	hsa-miR-4435	HITS-CLIP	23824327
MIRT671986	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671985	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671984	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT671996	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671995	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671994	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT667090	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671993	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT671992	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671991	hsa-miR-6131	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671990	hsa-miR-548s	HITS-CLIP	23824327
MIRT671989	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671988	hsa-miR-588	HITS-CLIP	23824327
MIRT671987	hsa-miR-4435	HITS-CLIP	23824327
MIRT671986	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671985	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671984	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT622958	hsa-miR-6844	HITS-CLIP	23824327
MIRT667097	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT667096	hsa-miR-764	HITS-CLIP	23824327
MIRT667095	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT667094	hsa-miR-4258	HITS-CLIP	23824327
MIRT667093	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT667092	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT667091	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT667090	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667089	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667087	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667088	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT667086	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT516925	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT516924	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT622958	hsa-miR-6844	HITS-CLIP	23824327
MIRT516926	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT516925	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT516924	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT516926	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT516925	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT516924	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT1207059	hsa-miR-1206	CLIP-seq
MIRT1207060	hsa-miR-128	CLIP-seq
MIRT1207061	hsa-miR-1292	CLIP-seq
MIRT1207062	hsa-miR-130a	CLIP-seq
MIRT1207063	hsa-miR-130b	CLIP-seq
MIRT1207064	hsa-miR-141	CLIP-seq
MIRT1207065	hsa-miR-148a	CLIP-seq
MIRT1207066	hsa-miR-148b	CLIP-seq
MIRT1207067	hsa-miR-152	CLIP-seq
MIRT1207068	hsa-miR-193a-3p	CLIP-seq
MIRT1207069	hsa-miR-193b	CLIP-seq
MIRT1207070	hsa-miR-200a	CLIP-seq
MIRT1207071	hsa-miR-301a	CLIP-seq
MIRT1207072	hsa-miR-301b	CLIP-seq
MIRT1207073	hsa-miR-3128	CLIP-seq
MIRT1207074	hsa-miR-3666	CLIP-seq
MIRT1207075	hsa-miR-371-5p	CLIP-seq
MIRT1207076	hsa-miR-410	CLIP-seq
MIRT1207077	hsa-miR-4295	CLIP-seq
MIRT1207078	hsa-miR-4470	CLIP-seq
MIRT1207079	hsa-miR-4471	CLIP-seq
MIRT1207080	hsa-miR-454	CLIP-seq
MIRT1207081	hsa-miR-4704-3p	CLIP-seq
MIRT1207082	hsa-miR-4720-5p	CLIP-seq
MIRT1207083	hsa-miR-4729	CLIP-seq
MIRT1207084	hsa-miR-4760-3p	CLIP-seq
MIRT1207085	hsa-miR-4775	CLIP-seq
MIRT1207086	hsa-miR-4799-3p	CLIP-seq
MIRT1207087	hsa-miR-561	CLIP-seq
MIRT1207088	hsa-miR-579	CLIP-seq
MIRT1207089	hsa-miR-590-3p	CLIP-seq
MIRT1207090	hsa-miR-664	CLIP-seq
MIRT1207091	hsa-miR-888	CLIP-seq
MIRT1207092	hsa-miR-892b	CLIP-seq
MIRT2059486	hsa-miR-1	CLIP-seq
MIRT1207064	hsa-miR-141	CLIP-seq
MIRT1207070	hsa-miR-200a	CLIP-seq
MIRT2059487	hsa-miR-206	CLIP-seq
MIRT1207073	hsa-miR-3128	CLIP-seq
MIRT2059488	hsa-miR-3673	CLIP-seq
MIRT1207078	hsa-miR-4470	CLIP-seq
MIRT1207082	hsa-miR-4720-5p	CLIP-seq
MIRT1207086	hsa-miR-4799-3p	CLIP-seq
MIRT1207087	hsa-miR-561	CLIP-seq
MIRT2059489	hsa-miR-613	CLIP-seq
MIRT2059486	hsa-miR-1	CLIP-seq
MIRT1207059	hsa-miR-1206	CLIP-seq
MIRT1207060	hsa-miR-128	CLIP-seq
MIRT1207061	hsa-miR-1292	CLIP-seq
MIRT1207062	hsa-miR-130a	CLIP-seq
MIRT1207063	hsa-miR-130b	CLIP-seq
MIRT1207064	hsa-miR-141	CLIP-seq
MIRT1207065	hsa-miR-148a	CLIP-seq
MIRT1207066	hsa-miR-148b	CLIP-seq
MIRT1207067	hsa-miR-152	CLIP-seq
MIRT1207070	hsa-miR-200a	CLIP-seq
MIRT2059487	hsa-miR-206	CLIP-seq
MIRT1207071	hsa-miR-301a	CLIP-seq
MIRT1207072	hsa-miR-301b	CLIP-seq
MIRT1207073	hsa-miR-3128	CLIP-seq
MIRT1207074	hsa-miR-3666	CLIP-seq
MIRT2059488	hsa-miR-3673	CLIP-seq
MIRT1207077	hsa-miR-4295	CLIP-seq
MIRT1207078	hsa-miR-4470	CLIP-seq
MIRT1207079	hsa-miR-4471	CLIP-seq
MIRT1207080	hsa-miR-454	CLIP-seq
MIRT1207082	hsa-miR-4720-5p	CLIP-seq
MIRT1207083	hsa-miR-4729	CLIP-seq
MIRT1207084	hsa-miR-4760-3p	CLIP-seq
MIRT1207086	hsa-miR-4799-3p	CLIP-seq
MIRT1207087	hsa-miR-561	CLIP-seq
MIRT1207088	hsa-miR-579	CLIP-seq
MIRT2059489	hsa-miR-613	CLIP-seq
MIRT1207090	hsa-miR-664	CLIP-seq
MIRT1207091	hsa-miR-888	CLIP-seq
MIRT2431819	hsa-miR-4652-3p	CLIP-seq
MIRT2431820	hsa-miR-659	CLIP-seq
MIRT2059486	hsa-miR-1	CLIP-seq
MIRT2059487	hsa-miR-206	CLIP-seq
MIRT2586090	hsa-miR-299-5p	CLIP-seq
MIRT1207073	hsa-miR-3128	CLIP-seq
MIRT2059488	hsa-miR-3673	CLIP-seq
MIRT2586091	hsa-miR-3679-3p	CLIP-seq
MIRT2586092	hsa-miR-369-3p	CLIP-seq
MIRT2586093	hsa-miR-374a	CLIP-seq
MIRT2586094	hsa-miR-374b	CLIP-seq
MIRT1207078	hsa-miR-4470	CLIP-seq
MIRT2431819	hsa-miR-4652-3p	CLIP-seq
MIRT1207082	hsa-miR-4720-5p	CLIP-seq
MIRT2586095	hsa-miR-4780	CLIP-seq
MIRT2586096	hsa-miR-4795-3p	CLIP-seq
MIRT1207086	hsa-miR-4799-3p	CLIP-seq
MIRT1207087	hsa-miR-561	CLIP-seq
MIRT2059489	hsa-miR-613	CLIP-seq
MIRT2431820	hsa-miR-659	CLIP-seq
MIRT2059486	hsa-miR-1	CLIP-seq
MIRT2059487	hsa-miR-206	CLIP-seq
MIRT1207073	hsa-miR-3128	CLIP-seq
MIRT2686908	hsa-miR-330-3p	CLIP-seq
MIRT2059488	hsa-miR-3673	CLIP-seq
MIRT1207075	hsa-miR-371-5p	CLIP-seq
MIRT1207078	hsa-miR-4470	CLIP-seq
MIRT2686909	hsa-miR-4695-3p	CLIP-seq
MIRT1207082	hsa-miR-4720-5p	CLIP-seq
MIRT2686910	hsa-miR-4760-5p	CLIP-seq
MIRT1207086	hsa-miR-4799-3p	CLIP-seq
MIRT1207087	hsa-miR-561	CLIP-seq
MIRT2059489	hsa-miR-613	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	TAS	10092216
GO:0005515	Function	Protein binding	IPI	17500595, 23275563, 25416956, 25825872, 28514442, 33961781
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	TAS	10092216
GO:0017124	Function	SH3 domain binding	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
610180	8510	ENSG00000134996

Q92882

Protein name

Osteoclast-stimulating factor 1

Protein function

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

PDB

1X2K , 1ZLM , 3EHQ , 3EHR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00018	SH3_1	18 → 63	SH3 domain	Domain
PF12796	Ank_2	60 → 137	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	77 → 170	Ankyrin repeats (3 copies)	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Present in osteoclasts (at protein level). {ECO:0000269|PubMed:10092216}.

Sequence

MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL
IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD
IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA
TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD

Sequence length

214

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Neoplasms	Associate	21501342	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Associate	30569177	★★★★★ ★☆☆☆☆ Found in Text Mining only

OSTF1 (osteoclast stimulating factor 1)