Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26523
Gene name Gene Name - the full gene name approved by the HGNC.	Argonaute RISC component 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AGO1
Synonyms (NCBI Gene) Gene synonyms aliases	EIF2C, EIF2C1, GERP95, NEDLBAS, Q99, hAgo1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p34.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represse

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000649	hsa-miR-503-5p	Luciferase reporter assay	19956200
MIRT019395	hsa-miR-148b-3p	Microarray	17612493
MIRT020233	hsa-miR-130b-3p	Sequencing	20371350
MIRT020459	hsa-miR-106b-5p	Microarray	17242205
MIRT028161	hsa-miR-93-5p	Sequencing	20371350
MIRT031191	hsa-miR-19b-3p	Sequencing	20371350
MIRT052451	hsa-let-7a-5p	CLASH	23622248
MIRT052451	hsa-let-7a-5p	CLASH	23622248
MIRT052100	hsa-let-7b-5p	CLASH	23622248
MIRT052100	hsa-let-7b-5p	CLASH	23622248
MIRT052100	hsa-let-7b-5p	CLASH	23622248
MIRT051847	hsa-let-7c-5p	CLASH	23622248
MIRT051847	hsa-let-7c-5p	CLASH	23622248
MIRT051424	hsa-let-7e-5p	CLASH	23622248
MIRT051424	hsa-let-7e-5p	CLASH	23622248
MIRT051424	hsa-let-7e-5p	CLASH	23622248
MIRT050855	hsa-miR-17-5p	CLASH	23622248
MIRT050855	hsa-miR-17-5p	CLASH	23622248
MIRT050855	hsa-miR-17-5p	CLASH	23622248
MIRT050855	hsa-miR-17-5p	CLASH	23622248
MIRT050491	hsa-miR-20a-5p	CLASH	23622248
MIRT050491	hsa-miR-20a-5p	CLASH	23622248
MIRT050491	hsa-miR-20a-5p	CLASH	23622248
MIRT050491	hsa-miR-20a-5p	CLASH	23622248
MIRT050491	hsa-miR-20a-5p	CLASH	23622248
MIRT050300	hsa-miR-25-3p	CLASH	23622248
MIRT050091	hsa-miR-26a-5p	CLASH	23622248
MIRT049967	hsa-miR-29a-3p	CLASH	23622248
MIRT049864	hsa-miR-31-5p	CLASH	23622248
MIRT049864	hsa-miR-31-5p	CLASH	23622248
MIRT049023	hsa-miR-92a-3p	CLASH	23622248
MIRT049023	hsa-miR-92a-3p	CLASH	23622248
MIRT049023	hsa-miR-92a-3p	CLASH	23622248
MIRT049023	hsa-miR-92a-3p	CLASH	23622248
MIRT049023	hsa-miR-92a-3p	CLASH	23622248
MIRT028161	hsa-miR-93-5p	CLASH	23622248
MIRT028161	hsa-miR-93-5p	CLASH	23622248
MIRT048678	hsa-miR-99a-5p	CLASH	23622248
MIRT048332	hsa-miR-106a-5p	CLASH	23622248
MIRT048053	hsa-miR-197-3p	CLASH	23622248
MIRT047934	hsa-miR-30c-5p	CLASH	23622248
MIRT047934	hsa-miR-30c-5p	CLASH	23622248
MIRT047786	hsa-miR-30d-5p	CLASH	23622248
MIRT047786	hsa-miR-30d-5p	CLASH	23622248
MIRT047389	hsa-miR-34a-5p	CLASH	23622248
MIRT047001	hsa-miR-212-3p	CLASH	23622248
MIRT046562	hsa-let-7g-5p	CLASH	23622248
MIRT045832	hsa-miR-138-5p	CLASH	23622248
MIRT045581	hsa-miR-149-5p	CLASH	23622248
MIRT045361	hsa-miR-185-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044946	hsa-miR-186-5p	CLASH	23622248
MIRT044876	hsa-miR-194-5p	CLASH	23622248
MIRT044872	hsa-miR-195-5p	CLASH	23622248
MIRT044422	hsa-miR-320a	CLASH	23622248
MIRT044422	hsa-miR-320a	CLASH	23622248
MIRT020459	hsa-miR-106b-5p	CLASH	23622248
MIRT020459	hsa-miR-106b-5p	CLASH	23622248
MIRT043875	hsa-miR-378a-3p	CLASH	23622248
MIRT043829	hsa-miR-330-3p	CLASH	23622248
MIRT043772	hsa-miR-328-3p	CLASH	23622248
MIRT043772	hsa-miR-328-3p	CLASH	23622248
MIRT043633	hsa-miR-326	CLASH	23622248
MIRT043039	hsa-miR-324-5p	CLASH	23622248
MIRT043039	hsa-miR-324-5p	CLASH	23622248
MIRT043039	hsa-miR-324-5p	CLASH	23622248
MIRT042472	hsa-miR-423-3p	CLASH	23622248
MIRT042384	hsa-miR-484	CLASH	23622248
MIRT041612	hsa-miR-146b-5p	CLASH	23622248
MIRT041207	hsa-miR-193b-3p	CLASH	23622248
MIRT041207	hsa-miR-193b-3p	CLASH	23622248
MIRT041207	hsa-miR-193b-3p	CLASH	23622248
MIRT041207	hsa-miR-193b-3p	CLASH	23622248
MIRT040923	hsa-miR-18a-3p	CLASH	23622248
MIRT040258	hsa-miR-615-3p	CLASH	23622248
MIRT039585	hsa-miR-628-3p	CLASH	23622248
MIRT039533	hsa-miR-652-3p	CLASH	23622248
MIRT039391	hsa-miR-421	CLASH	23622248
MIRT039094	hsa-miR-769-3p	CLASH	23622248
MIRT038746	hsa-miR-93-3p	CLASH	23622248
MIRT038746	hsa-miR-93-3p	CLASH	23622248
MIRT038199	hsa-miR-151a-5p	CLASH	23622248
MIRT037811	hsa-miR-455-3p	CLASH	23622248
MIRT037644	hsa-miR-744-5p	CLASH	23622248
MIRT037333	hsa-miR-877-5p	CLASH	23622248
MIRT036850	hsa-miR-877-3p	CLASH	23622248
MIRT036850	hsa-miR-877-3p	CLASH	23622248
MIRT036167	hsa-miR-320c	CLASH	23622248
MIRT052451	hsa-let-7a-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT052451	hsa-let-7a-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT052100	hsa-let-7b-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT051847	hsa-let-7c-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT437855	hsa-let-7d-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT051424	hsa-let-7e-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT437856	hsa-let-7f-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT046562	hsa-let-7g-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT437857	hsa-let-7i-5p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT249123	hsa-miR-103a-3p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT026978	hsa-miR-107	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23426184
MIRT438862	hsa-miR-1-3p	Luciferase reporter assay	23276603
MIRT438862	hsa-miR-1-3p	Luciferase reporter assay	23276603
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT640179	hsa-miR-6165	HITS-CLIP	23824327
MIRT640178	hsa-miR-4690-5p	HITS-CLIP	23824327
MIRT640177	hsa-miR-6510-5p	HITS-CLIP	23824327
MIRT640176	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT114120	hsa-miR-4779	HITS-CLIP	23824327
MIRT640174	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT640175	hsa-miR-3919	HITS-CLIP	23824327
MIRT640173	hsa-miR-4266	HITS-CLIP	23824327
MIRT609072	hsa-miR-218-5p	HITS-CLIP	24906430
MIRT609071	hsa-miR-219a-2-3p	HITS-CLIP	24906430
MIRT038746	hsa-miR-93-3p	HITS-CLIP	24906430
MIRT609070	hsa-miR-8075	HITS-CLIP	24906430
MIRT495731	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495730	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495729	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495728	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495727	hsa-miR-940	PAR-CLIP	22291592
MIRT495726	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495725	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495724	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495723	hsa-miR-1324	PAR-CLIP	22291592
MIRT495721	hsa-miR-3166	PAR-CLIP	22291592
MIRT495731	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495730	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495729	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495728	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495727	hsa-miR-940	PAR-CLIP	22291592
MIRT495726	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495725	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495724	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495723	hsa-miR-1324	PAR-CLIP	22291592
MIRT495722	hsa-miR-4756-3p	PAR-CLIP	22291592
MIRT495721	hsa-miR-3166	PAR-CLIP	22291592
MIRT114121	hsa-miR-2467-3p	PAR-CLIP	22291592
MIRT114113	hsa-miR-3678-3p	PAR-CLIP	22291592
MIRT445759	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445757	hsa-miR-4436b-3p	PAR-CLIP	22100165
MIRT445755	hsa-miR-4632-5p	PAR-CLIP	22100165
MIRT445756	hsa-miR-6735-5p	PAR-CLIP	22100165
MIRT445754	hsa-miR-6879-5p	PAR-CLIP	22100165
MIRT445753	hsa-miR-7843-5p	PAR-CLIP	22100165
MIRT039585	hsa-miR-628-3p	PAR-CLIP	22100165
MIRT445752	hsa-miR-325	PAR-CLIP	22100165
MIRT445751	hsa-miR-517-5p	PAR-CLIP	22100165
MIRT445750	hsa-miR-1251-5p	PAR-CLIP	22100165
MIRT445749	hsa-miR-942-5p	PAR-CLIP	22100165
MIRT445748	hsa-miR-3616-3p	PAR-CLIP	22100165
MIRT445747	hsa-miR-4721	PAR-CLIP	22100165
MIRT445746	hsa-miR-4684-5p	PAR-CLIP	22100165
MIRT445745	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445744	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445742	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT020459	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT050491	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT020459	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT050855	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT137255	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028161	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT137260	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT137249	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT031191	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT050491	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT495723	hsa-miR-1324	HITS-CLIP	27418678
MIRT495723	hsa-miR-1324	HITS-CLIP	27418678
MIRT495723	hsa-miR-1324	HITS-CLIP	27418678
MIRT495723	hsa-miR-1324	HITS-CLIP	27418678
MIRT495723	hsa-miR-1324	HITS-CLIP	27418678
MIRT495731	hsa-miR-1910-3p	HITS-CLIP	27418678
MIRT495731	hsa-miR-1910-3p	HITS-CLIP	27418678
MIRT495731	hsa-miR-1910-3p	HITS-CLIP	27418678
MIRT495731	hsa-miR-1910-3p	HITS-CLIP	27418678
MIRT495731	hsa-miR-1910-3p	HITS-CLIP	27418678
MIRT495726	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT495726	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT495726	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT495726	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT495726	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT495721	hsa-miR-3166	HITS-CLIP	27418678
MIRT495721	hsa-miR-3166	HITS-CLIP	27418678
MIRT495721	hsa-miR-3166	HITS-CLIP	27418678
MIRT495721	hsa-miR-3166	HITS-CLIP	27418678
MIRT495721	hsa-miR-3166	HITS-CLIP	27418678
MIRT495725	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT495725	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT495725	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT495725	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT495725	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT495724	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT495724	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT495724	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT495724	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT495724	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT495730	hsa-miR-6511a-5p	HITS-CLIP	27418678
MIRT495730	hsa-miR-6511a-5p	HITS-CLIP	27418678
MIRT495730	hsa-miR-6511a-5p	HITS-CLIP	27418678
MIRT495730	hsa-miR-6511a-5p	HITS-CLIP	27418678
MIRT495730	hsa-miR-6511a-5p	HITS-CLIP	27418678
MIRT495729	hsa-miR-6808-5p	HITS-CLIP	27418678
MIRT495729	hsa-miR-6808-5p	HITS-CLIP	27418678
MIRT495729	hsa-miR-6808-5p	HITS-CLIP	27418678
MIRT495729	hsa-miR-6808-5p	HITS-CLIP	27418678
MIRT495729	hsa-miR-6808-5p	HITS-CLIP	27418678
MIRT495728	hsa-miR-6893-5p	HITS-CLIP	27418678
MIRT495728	hsa-miR-6893-5p	HITS-CLIP	27418678
MIRT495728	hsa-miR-6893-5p	HITS-CLIP	27418678
MIRT495728	hsa-miR-6893-5p	HITS-CLIP	27418678
MIRT495728	hsa-miR-6893-5p	HITS-CLIP	27418678
MIRT495727	hsa-miR-940	HITS-CLIP	27418678
MIRT495727	hsa-miR-940	HITS-CLIP	27418678
MIRT495727	hsa-miR-940	HITS-CLIP	27418678
MIRT495727	hsa-miR-940	HITS-CLIP	27418678
MIRT495727	hsa-miR-940	HITS-CLIP	27418678
MIRT734881	hsa-miR-153-5p	Luciferase reporter assay, Western blotting	33414440
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT709903	hsa-miR-892b	HITS-CLIP	19536157
MIRT709902	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT709901	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT445749	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709900	hsa-miR-4777-3p	HITS-CLIP	19536157
MIRT709899	hsa-miR-4279	HITS-CLIP	19536157
MIRT709898	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT709897	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709896	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT640179	hsa-miR-6165	HITS-CLIP	23824327
MIRT640178	hsa-miR-4690-5p	HITS-CLIP	23824327
MIRT640177	hsa-miR-6510-5p	HITS-CLIP	23824327
MIRT640176	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT114120	hsa-miR-4779	HITS-CLIP	23824327
MIRT640174	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT640175	hsa-miR-3919	HITS-CLIP	23824327
MIRT640173	hsa-miR-4266	HITS-CLIP	23824327
MIRT495731	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495730	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495729	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495728	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495727	hsa-miR-940	PAR-CLIP	22291592
MIRT495726	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495725	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495724	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495723	hsa-miR-1324	PAR-CLIP	22291592
MIRT495721	hsa-miR-3166	PAR-CLIP	22291592
MIRT495731	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT495730	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT495729	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT495728	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT495727	hsa-miR-940	PAR-CLIP	22291592
MIRT495726	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT495725	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT495724	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT495723	hsa-miR-1324	PAR-CLIP	22291592
MIRT495722	hsa-miR-4756-3p	PAR-CLIP	22291592
MIRT495721	hsa-miR-3166	PAR-CLIP	22291592
MIRT114121	hsa-miR-2467-3p	PAR-CLIP	22291592
MIRT114113	hsa-miR-3678-3p	PAR-CLIP	22291592
MIRT445759	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445757	hsa-miR-4436b-3p	PAR-CLIP	22100165
MIRT445755	hsa-miR-4632-5p	PAR-CLIP	22100165
MIRT445756	hsa-miR-6735-5p	PAR-CLIP	22100165
MIRT445754	hsa-miR-6879-5p	PAR-CLIP	22100165
MIRT445753	hsa-miR-7843-5p	PAR-CLIP	22100165
MIRT039585	hsa-miR-628-3p	PAR-CLIP	22100165
MIRT445752	hsa-miR-325	PAR-CLIP	22100165
MIRT445751	hsa-miR-517-5p	PAR-CLIP	22100165
MIRT445750	hsa-miR-1251-5p	PAR-CLIP	22100165
MIRT445749	hsa-miR-942-5p	PAR-CLIP	22100165
MIRT445748	hsa-miR-3616-3p	PAR-CLIP	22100165
MIRT445747	hsa-miR-4721	PAR-CLIP	22100165
MIRT445746	hsa-miR-4684-5p	PAR-CLIP	22100165
MIRT445745	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445744	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445742	hsa-miR-6734-5p	PAR-CLIP	22100165

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SOX4	Unknown	19147588

Show/Hide all(59)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IEA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IDA	18771919
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000993	Function	RNA polymerase II complex binding	IDA	25336585
GO:0001046	Function	Core promoter sequence-specific DNA binding	IMP	25336585
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	23809764
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	19966796
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IDA	19966796
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0004521	Function	RNA endonuclease activity	IDA	23809764
GO:0005515	Function	Protein binding	IPI	12526743, 16289642, 16756390, 17891150, 17932509, 18482256, 19167051, 19324964, 19383768, 19716330, 20616046, 22484317, 22915799, 25036637, 25336585, 28330616, 28683311, 33961781, 35271311, 35709258
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IC	25336585
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15260970, 17932509, 20014101
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006417	Process	Regulation of translation	IEA
GO:0010586	Process	MiRNA metabolic process	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0016442	Component	RISC complex	IBA
GO:0016442	Component	RISC complex	IDA	15260970, 17932509, 19966796
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	23426184
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031054	Process	Pre-miRNA processing	IBA
GO:0031054	Process	Pre-miRNA processing	IDA	19966796
GO:0031054	Process	Pre-miRNA processing	IEA
GO:0035194	Process	Regulatory ncRNA-mediated post-transcriptional gene silencing	IBA
GO:0035196	Process	MiRNA processing	IMP	22795694
GO:0035198	Function	MiRNA binding	IBA
GO:0035198	Function	MiRNA binding	IDA	15260970
GO:0035198	Function	MiRNA binding	IEA
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	18771919
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IEA
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	15260970
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IBA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IEA
GO:0043488	Process	Regulation of mRNA stability	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	25336585
GO:0070578	Component	RISC-loading complex	IDA	19966796
GO:0070578	Component	RISC-loading complex	IEA
GO:0070922	Process	RISC complex assembly	IDA	19966796
GO:0070922	Process	RISC complex assembly	IEA
GO:0090625	Process	SiRNA-mediated gene silencing by mRNA destabilization	IDA	15260970
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
606228	3262	ENSG00000092847

Protein

UniProt ID

Q9UL18

Protein name

Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)

Protein function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not

PDB

1SI2 , 1SI3 , 4KRE , 4KRF , 4KXT , 5W6V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16486	ArgoN	34 → 164	N-terminal domain of argonaute	Domain
PF08699	ArgoL1	174 → 224	Argonaute linker 1 domain	Domain
PF02170	PAZ	229 → 363	PAZ domain	Domain
PF16488	ArgoL2	372 → 418	Argonaute linker 2 domain	Family
PF16487	ArgoMid	427 → 509	Mid domain of argonaute	Domain
PF02171	Piwi	515 → 816	Piwi domain	Family

Sequence

MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK
PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE
GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF
SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN
IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ
TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS
TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG
RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG
MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM
ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP
AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT
RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE
RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL
TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL
AKAVQVHQDTLRTMYFA

Sequence length

857

Interactions

View interactions

	Reactome
			Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	27669275
Autistic Disorder	Associate	34930816
Breast Neoplasms	Associate	23696926, 30284063, 32812257
Carcinoma Hepatocellular	Associate	21319996, 29487329
Carcinoma Renal Cell	Associate	23696926
Cerebral Infarction	Associate	32744319
Choroidal Effusions	Associate	20716115
Cystic Fibrosis	Associate	31664087
Developmental Disabilities	Associate	25271087, 34930816
Esophageal Squamous Cell Carcinoma	Associate	36990227
Graves Disease	Associate	29256262
Heart Diseases	Associate	32400052
Heart Failure	Associate	32400052
Hepatitis B	Associate	30627556
Insulin Resistance	Associate	30627556
Intellectual Disability	Associate	34930816
Language Development Disorders	Associate	34930816
Leprosy	Associate	36142557
Lung Neoplasms	Associate	27669275, 33832481
Lymphatic Metastasis	Stimulate	23696926
Muscle Hypotonia	Associate	25271087
Neoplasm Metastasis	Associate	29487329
Neoplasms	Inhibit	21846468
Neoplasms	Associate	23696926, 24086155, 25656609, 29487329, 33684100
Neoplasms	Stimulate	30284063
Neuroblastoma	Associate	21846468
Neurologic Manifestations	Associate	25271087
Prostatic Neoplasms	Associate	30627556
Small Cell Lung Carcinoma	Associate	30627556
Squamous Cell Carcinoma of Head and Neck	Associate	20924207
Thyroiditis Autoimmune	Associate	29256262
Urinary Bladder Neoplasms	Associate	25656609, 29857476
Virus Diseases	Associate	30627556

AGO1 (argonaute RISC component 1)