Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26502
Gene name	Nuclear prelamin A recognition factor
Gene symbol	NARF
Synonyms (NCBI Gene)	IOP2
Chromosome	17
Chromosome location	17q25.3
Summary	Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protei

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Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027539	hsa-miR-98-5p	Microarray	19088304
MIRT030389	hsa-miR-24-3p	Microarray	19748357
MIRT031638	hsa-miR-16-5p	Microarray	21199864
MIRT042570	hsa-miR-423-3p	CLASH	23622248
MIRT701553	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT459158	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT459157	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT701552	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT701551	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT701550	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT701549	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT701548	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT701547	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT459155	hsa-miR-4257	HITS-CLIP	23313552
MIRT701546	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT701545	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT459154	hsa-miR-5186	HITS-CLIP	23313552
MIRT459153	hsa-miR-3160-3p	HITS-CLIP	23313552
MIRT459152	hsa-miR-558	HITS-CLIP	23313552
MIRT459150	hsa-miR-4487	HITS-CLIP	23313552
MIRT459151	hsa-miR-1827	HITS-CLIP	23313552
MIRT459149	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT459147	hsa-miR-6086	HITS-CLIP	23313552
MIRT459148	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT459146	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT459145	hsa-miR-3612	HITS-CLIP	23313552
MIRT459144	hsa-miR-650	HITS-CLIP	23313552
MIRT701544	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT701543	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT701542	hsa-miR-7703	HITS-CLIP	23313552
MIRT701541	hsa-miR-4325	HITS-CLIP	23313552
MIRT459143	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT459142	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT459158	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT459157	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT459155	hsa-miR-4257	PAR-CLIP	23592263
MIRT459156	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT459154	hsa-miR-5186	PAR-CLIP	23592263
MIRT459153	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT459152	hsa-miR-558	PAR-CLIP	23592263
MIRT459150	hsa-miR-4487	PAR-CLIP	23592263
MIRT459151	hsa-miR-1827	PAR-CLIP	23592263
MIRT459149	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT459147	hsa-miR-6086	PAR-CLIP	23592263
MIRT459148	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT459146	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT459145	hsa-miR-3612	PAR-CLIP	23592263
MIRT459144	hsa-miR-650	PAR-CLIP	23592263
MIRT459143	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT459142	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT459156	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT459151	hsa-miR-1827	PAR-CLIP	27292025
MIRT459151	hsa-miR-1827	PAR-CLIP	27292025
MIRT459158	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT459158	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT459148	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT459148	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT459153	hsa-miR-3160-3p	PAR-CLIP	27292025
MIRT459153	hsa-miR-3160-3p	PAR-CLIP	27292025
MIRT459145	hsa-miR-3612	PAR-CLIP	27292025
MIRT459145	hsa-miR-3612	PAR-CLIP	27292025
MIRT459149	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT459149	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT459155	hsa-miR-4257	PAR-CLIP	27292025
MIRT459155	hsa-miR-4257	PAR-CLIP	27292025
MIRT459150	hsa-miR-4487	PAR-CLIP	27292025
MIRT459150	hsa-miR-4487	PAR-CLIP	27292025
MIRT459143	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT459143	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT459154	hsa-miR-5186	PAR-CLIP	27292025
MIRT459154	hsa-miR-5186	PAR-CLIP	27292025
MIRT459152	hsa-miR-558	PAR-CLIP	27292025
MIRT459152	hsa-miR-558	PAR-CLIP	27292025
MIRT459147	hsa-miR-6086	PAR-CLIP	27292025
MIRT459147	hsa-miR-6086	PAR-CLIP	27292025
MIRT459146	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT459146	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT459144	hsa-miR-650	PAR-CLIP	27292025
MIRT459144	hsa-miR-650	PAR-CLIP	27292025
MIRT459157	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT459157	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT459142	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT459142	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT701553	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT459158	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT459157	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT701552	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT701551	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT701550	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT701549	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT701548	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT701547	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT459155	hsa-miR-4257	HITS-CLIP	23313552
MIRT701546	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT701545	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT459154	hsa-miR-5186	HITS-CLIP	23313552
MIRT459153	hsa-miR-3160-3p	HITS-CLIP	23313552
MIRT459152	hsa-miR-558	HITS-CLIP	23313552
MIRT459150	hsa-miR-4487	HITS-CLIP	23313552
MIRT459151	hsa-miR-1827	HITS-CLIP	23313552
MIRT459149	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT459147	hsa-miR-6086	HITS-CLIP	23313552
MIRT459148	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT459146	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT459145	hsa-miR-3612	HITS-CLIP	23313552
MIRT459144	hsa-miR-650	HITS-CLIP	23313552
MIRT701544	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT701543	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT701542	hsa-miR-7703	HITS-CLIP	23313552
MIRT701541	hsa-miR-4325	HITS-CLIP	23313552
MIRT459143	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT459142	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT459158	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT459157	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT459155	hsa-miR-4257	PAR-CLIP	23592263
MIRT459156	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT459154	hsa-miR-5186	PAR-CLIP	23592263
MIRT459153	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT459152	hsa-miR-558	PAR-CLIP	23592263
MIRT459150	hsa-miR-4487	PAR-CLIP	23592263
MIRT459151	hsa-miR-1827	PAR-CLIP	23592263
MIRT459149	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT459147	hsa-miR-6086	PAR-CLIP	23592263
MIRT459148	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT459146	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT459145	hsa-miR-3612	PAR-CLIP	23592263
MIRT459144	hsa-miR-650	PAR-CLIP	23592263
MIRT459143	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT459142	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT2050368	hsa-miR-3127-5p	CLIP-seq
MIRT2050369	hsa-miR-3918	CLIP-seq
MIRT2050370	hsa-miR-4436b-3p	CLIP-seq
MIRT2050371	hsa-miR-4469	CLIP-seq
MIRT2050372	hsa-miR-4749-3p	CLIP-seq
MIRT2050373	hsa-miR-642a	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005521	Function	Lamin binding	IBA
GO:0005521	Function	Lamin binding	IPI	10514485
GO:0005634	Component	Nucleus	IEA
GO:0005638	Component	Lamin filament	IBA
GO:0005638	Component	Lamin filament	IDA	10514485
GO:0005652	Component	Nuclear lamina	TAS	10514485
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0031981	Component	Nuclear lumen	IDA	10514485

MIM	HGNC	e!Ensembl
605349	29916	ENSG00000141562

Q9UHQ1

Protein name

Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02906	Fe_hyd_lg_C	92 → 382	Iron only hydrogenase large subunit, C-terminal domain	Domain
PF02256	Fe_hyd_SSU	393 → 445	Iron hydrogenase small subunit	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain. {ECO:0000269|PubMed:10514485}.

Sequence

MKCEHCTRKECSKKTKTDDQENVSADAPSPAQENGEKGEFHKLADAKIFLSDCLACDSCM
TAEEGVQLSQQNAKDFFRVLNLNKKCDTSKHKVLVVSVCPQSLPYFAAKFNLSVTDASRR
LCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRYRQHSEEERTLPMLTSACPGWVRYAE
RVLGRPITAHLCTAKSPQQVMGSLVKDYFARQQNLSPEKIFHVIVAPCYDKKLEALQESL
PPALHGSRGADCVLTSGEIAQIMEQGDLSVRDAAVDTLFGDLKEDKVTRHDGASSDGHLA
HIFRHAAKELFNEDVEEVTYRALRNKDFQEVTLEKNGEVVLRFAAAYGFRNIQNMILKLK
KGKFPFHFVEVLACAGGCLNGRGQAQTPDGHADKALLRQMEGIYADIPVRRPESSAHVQE
LYQEWLEGINSPKAREVLHTTYQSQERGTHSLDIKW

Sequence length

456

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OSTEONECROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	37768037	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Stimulate	37768037	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia Brain	Associate	37768037	★★★★★ ★☆☆☆☆ Found in Text Mining only

NARF (nuclear prelamin A recognition factor)