PLEK2 (pleckstrin 2)

Gene

• Entrez ID: 26499
• Gene name: Pleckstrin 2
• Gene symbol: PLEK2
• Synonyms (NCBI Gene): -
• Chromosome: 14
• Chromosome location: 14q23.3-q24.1
• Summary: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement compo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016423	hsa-miR-193b-3p	Microarray	20304954
MIRT021685	hsa-miR-138-5p	qRT-PCR	21770894
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240691	hsa-miR-199a-5p	CLIP-seq
MIRT1240692	hsa-miR-199b-5p	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT1240694	hsa-miR-3065-5p	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT1240696	hsa-miR-3622b-5p	CLIP-seq
MIRT1240697	hsa-miR-3915	CLIP-seq
MIRT1240698	hsa-miR-3928	CLIP-seq
MIRT1240699	hsa-miR-421	CLIP-seq
MIRT1240700	hsa-miR-4272	CLIP-seq
MIRT1240701	hsa-miR-4435	CLIP-seq
MIRT1240702	hsa-miR-4649-3p	CLIP-seq
MIRT1240703	hsa-miR-4680-5p	CLIP-seq
MIRT2070760	hsa-miR-1252	CLIP-seq
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT2070761	hsa-miR-2110	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT2070762	hsa-miR-4271	CLIP-seq
MIRT2070763	hsa-miR-4426	CLIP-seq
MIRT2070764	hsa-miR-4533	CLIP-seq
MIRT2070765	hsa-miR-4647	CLIP-seq
MIRT2070766	hsa-miR-4662b	CLIP-seq
MIRT2070767	hsa-miR-4699-5p	CLIP-seq
MIRT2070768	hsa-miR-4725-3p	CLIP-seq
MIRT2070769	hsa-miR-4747-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031346	Process	Positive regulation of cell projection organization	IEA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IEA
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IEA
GO:0120034	Process	Positive regulation of plasma membrane bounded cell projection assembly	IEA

Other IDs

• MIM: 608007
• HGNC: 19238
• e!Ensembl: ENSG00000100558

Protein

• UniProt ID: Q9NYT0
• Protein name: Pleckstrin-2
• Protein function: May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
• PDB: 1X1G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	5 → 104	PH domain	Domain
  PF00610	DEP	142 → 223	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
  PF00169	PH	248 → 353	PH domain	Domain

• Sequence:

  MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC
  PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS
  FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA
  VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS
  TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL
  VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT

• Sequence length: 353

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