Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26499
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLEK2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q23.3-q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement compo

Show/Hide all(29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016423	hsa-miR-193b-3p	Microarray	20304954
MIRT021685	hsa-miR-138-5p	qRT-PCR	21770894
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240691	hsa-miR-199a-5p	CLIP-seq
MIRT1240692	hsa-miR-199b-5p	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT1240694	hsa-miR-3065-5p	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT1240696	hsa-miR-3622b-5p	CLIP-seq
MIRT1240697	hsa-miR-3915	CLIP-seq
MIRT1240698	hsa-miR-3928	CLIP-seq
MIRT1240699	hsa-miR-421	CLIP-seq
MIRT1240700	hsa-miR-4272	CLIP-seq
MIRT1240701	hsa-miR-4435	CLIP-seq
MIRT1240702	hsa-miR-4649-3p	CLIP-seq
MIRT1240703	hsa-miR-4680-5p	CLIP-seq
MIRT2070760	hsa-miR-1252	CLIP-seq
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT2070761	hsa-miR-2110	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT2070762	hsa-miR-4271	CLIP-seq
MIRT2070763	hsa-miR-4426	CLIP-seq
MIRT2070764	hsa-miR-4533	CLIP-seq
MIRT2070765	hsa-miR-4647	CLIP-seq
MIRT2070766	hsa-miR-4662b	CLIP-seq
MIRT2070767	hsa-miR-4699-5p	CLIP-seq
MIRT2070768	hsa-miR-4725-3p	CLIP-seq
MIRT2070769	hsa-miR-4747-5p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031532	Process	Actin cytoskeleton reorganization	IBA	21873635
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IEA
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IEA
GO:0120034	Process	Positive regulation of plasma membrane bounded cell projection assembly	IEA

MIM	HGNC	e!Ensembl
608007	19238	ENSG00000100558

Protein

UniProt ID

Q9NYT0

Protein name

Pleckstrin-2

Protein function

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

PDB

1X1G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	5 → 104	PH domain	Domain
PF00610	DEP	142 → 223	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
PF00169	PH	248 → 353	PH domain	Domain

Sequence

MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC
PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS
FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA
VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS
TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL
VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT

Sequence length

353

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		30626913	ClinVar

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	32819300, 37322027
Adenocarcinoma of Lung	Stimulate	33084541
Breast Neoplasms	Associate	36928924
Carcinoma Squamous Cell	Stimulate	33084541
Colorectal Neoplasms	Associate	34676872
Glioblastoma	Associate	30816427
Glioma	Associate	35936006
Hypoxia	Associate	34331382
Immunoglobulin Light chain Amyloidosis	Associate	32922167
Lung Neoplasms	Associate	37910672
Melanoma	Associate	21698244
Multiple Myeloma	Associate	32922167
Neoplasm Metastasis	Associate	34331382, 36928924
Squamous Cell Carcinoma of Head and Neck	Associate	34331382

PLEK2 (pleckstrin 2)